2010
DOI: 10.1002/ana.22212
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Brain drain: A bottom‐up approach to normal pressure hydrocephalus

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Cited by 3 publications
(4 citation statements)
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“…Structural changes of the ventricular wall, alteration in periventricular blood flow, free-radical reactions, and hippocampal degeneration have all been implicated [10-13]. Most studies point to reduced CSF absorption by the arachnoid granulations as the most likely culprit of INPH [14].…”
Section: Discussionmentioning
confidence: 99%
“…Structural changes of the ventricular wall, alteration in periventricular blood flow, free-radical reactions, and hippocampal degeneration have all been implicated [10-13]. Most studies point to reduced CSF absorption by the arachnoid granulations as the most likely culprit of INPH [14].…”
Section: Discussionmentioning
confidence: 99%
“…Patients diagnosed with iNPH show differential responses to the cerebrospinal fluid (Ko et al, 2017). Patients with a positive TT response can obtain obvious improvements in cognitive function after shunt surgery, whilst most TT negative patients usually experience very poor postoperative effects often with no change in cognitive deficits (McKhann and Mayeux, 2010;Wolfsegger and Topakian, 2017). These observations suggest that different mechanisms of cognitive impairment may Abbreviations: DTI, diffusion tensor imaging; TBSS, tract-based spatial statistics; WM, white matter; FA, fractional anisotropy; MD, mean diffusivity; AD, axial diffusivity; RD, radial diffusivity; TT, tap test; TT-R, TT responsive group; TT-nR, TT non-responsive group; MMSE, Mini-Mental State Examination; DST, digit span forward; VFT-A, Verbal Fluency Test -ANIMAL; TMT-A, Trail Making Test A; CDT, Clock Drawing Test; CWT-B, Stroop Color Word Test-card B; L-ATR, anterior thalamic radiation L; R-ATR, anterior thalamic radiation R; L-PTR, posterior thalamic radiation include optic radiation L; R-PTR, posterior thalamic radiation include optic radiation R; L-ACR, anterior corona radiata R; R-ACR, anterior corona radiata L; L-SCR, superior corona radiata R; R-SCR, superior corona radiata L; L-PCR, posterior corona radiata R; R-PCR, posterior corona radiata L; F-major, forceps major; F-minor, forceps minor; GCC, genu of corpus callosum; BCC, body of corpus callosum; SCC, splenium of corpus callosum; L-TAP, tapetum L; R-TAP, tapetum R; FN, fornix (column and body of fornix); L-CgC, cingulum cingulate gyrus L; R-CgC, cingulum cingulate gyrus R; L-CgH, cingulum hippocampus L; R-CgH, cingulum hippocampus R; L-SFOF, superior fronto-occipital fasciculus L; R-SFOF, superior frontooccipital fasciculus R; L-IFOF, inferior frontooccipital fasciculus L; R-IFOF, inferior frontooccipital fasciculus R; L-ILF, inferior longitudinal fasciculus L; R-ILF, inferior longitudinal fasciculus R; L-SLF, superior longitudinal fasciculus L; R-SLF, superior longitudinal fasciculus R; L-SLFT, superior longitudinal fasciculus temporal part L; R-SLFT, superior longitudinal fasciculus temporal part R; L-SS, sagittal stratum (include ILF and IFOF) L; R-SS, sagittal stratum (include ILF and IFOF) R; L-UF, uncinate fasciculus L; R-UF, uncinate fasciculus R.…”
Section: Introductionmentioning
confidence: 99%
“…Patients diagnosed with iNPH show differential responses to the cerebrospinal fluid ( Ko et al, 2017 ). Patients with a positive TT response can obtain obvious improvements in cognitive function after shunt surgery, whilst most TT negative patients usually experience very poor postoperative effects often with no change in cognitive deficits ( McKhann and Mayeux, 2010 ; Wolfsegger and Topakian, 2017 ). These observations suggest that different mechanisms of cognitive impairment may occur between TT responders and non-responders and could potentially be used to predict cognitive function outcomes after surgery in iNPH patients.…”
Section: Introductionmentioning
confidence: 99%
“…[ 15 , 18 ] At present, the gold standard is objective improvement of symptoms after shunt surgery (operational diagnosis); therefore, tap test (which simulates a shunt) has become a common, minimally invasive, and easily reproducible method. [ 2 , 4 , 7 , 8 , 13 ] Symptoms, imaging, and neurologic tests have a positive predictive value (PPV) of 50–61% which suggests a moderate improvement after shunt surgery. [ 8 , 9 , 16 ] Because the prognostic value of imaging is limited, other tests are needed to increase the probability of identifying patients with iNPH who will respond to shunt surgery.…”
Section: Introductionmentioning
confidence: 99%