“…Patients diagnosed with iNPH show differential responses to the cerebrospinal fluid (Ko et al, 2017). Patients with a positive TT response can obtain obvious improvements in cognitive function after shunt surgery, whilst most TT negative patients usually experience very poor postoperative effects often with no change in cognitive deficits (McKhann and Mayeux, 2010;Wolfsegger and Topakian, 2017). These observations suggest that different mechanisms of cognitive impairment may Abbreviations: DTI, diffusion tensor imaging; TBSS, tract-based spatial statistics; WM, white matter; FA, fractional anisotropy; MD, mean diffusivity; AD, axial diffusivity; RD, radial diffusivity; TT, tap test; TT-R, TT responsive group; TT-nR, TT non-responsive group; MMSE, Mini-Mental State Examination; DST, digit span forward; VFT-A, Verbal Fluency Test -ANIMAL; TMT-A, Trail Making Test A; CDT, Clock Drawing Test; CWT-B, Stroop Color Word Test-card B; L-ATR, anterior thalamic radiation L; R-ATR, anterior thalamic radiation R; L-PTR, posterior thalamic radiation include optic radiation L; R-PTR, posterior thalamic radiation include optic radiation R; L-ACR, anterior corona radiata R; R-ACR, anterior corona radiata L; L-SCR, superior corona radiata R; R-SCR, superior corona radiata L; L-PCR, posterior corona radiata R; R-PCR, posterior corona radiata L; F-major, forceps major; F-minor, forceps minor; GCC, genu of corpus callosum; BCC, body of corpus callosum; SCC, splenium of corpus callosum; L-TAP, tapetum L; R-TAP, tapetum R; FN, fornix (column and body of fornix); L-CgC, cingulum cingulate gyrus L; R-CgC, cingulum cingulate gyrus R; L-CgH, cingulum hippocampus L; R-CgH, cingulum hippocampus R; L-SFOF, superior fronto-occipital fasciculus L; R-SFOF, superior frontooccipital fasciculus R; L-IFOF, inferior frontooccipital fasciculus L; R-IFOF, inferior frontooccipital fasciculus R; L-ILF, inferior longitudinal fasciculus L; R-ILF, inferior longitudinal fasciculus R; L-SLF, superior longitudinal fasciculus L; R-SLF, superior longitudinal fasciculus R; L-SLFT, superior longitudinal fasciculus temporal part L; R-SLFT, superior longitudinal fasciculus temporal part R; L-SS, sagittal stratum (include ILF and IFOF) L; R-SS, sagittal stratum (include ILF and IFOF) R; L-UF, uncinate fasciculus L; R-UF, uncinate fasciculus R.…”