Brain Functional Alterations in Long-term Unilateral Hearing Impairment

Zhu, Jun; Cui, Jian; Cao, Gang; Ji, Jianwu; Chang, Xu; Zhang, Chongjie; Liu, Yongbo

doi:10.1016/j.acra.2019.09.027

Cited by 5 publications

(3 citation statements)

References 43 publications

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“…We found that the ALFF value of the left superior temporal gyrus correlated with disease severity (hearing threshold), suggesting a mechanism involving disuse and atrophy. However, our result is incompatible with the previous finding that patients with right-sided SNHL showed higher fALFF values in left Heschl’s gyrus and superior temporal gyrus ( Zhu et al, 2020 ), which may be explained by that our study included congenital hearing loss whereas the previous study included post-lingual hearing loss. Besides, methodological differences, including regional activity measurements and head-motion processing, might be another reason.…”

Section: Discussioncontrasting

confidence: 99%

Altered regional activity and connectivity of functional brain networks in congenital unilateral conductive hearing loss

Yang

Liu

Fan

et al. 2021

NeuroImage: Clinical

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Highlights Focal brain function and seed-based functional connectivity were first analyzed in congenital unilateral CHL. Auditory and visual networks showed altered regional activity and functional connectivity. Abnormally high activity in the left ITG was positively correlated with duration of disease. Higher-order networks including frontoparietal regions and DMN demonstrated abnormal functional connectivity. GSR may produce spurious signals in SBFC analyses.

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Section: Discussioncontrasting

confidence: 99%

Altered regional activity and connectivity of functional brain networks in congenital unilateral conductive hearing loss

Yang

Liu

Fan

et al. 2021

NeuroImage: Clinical

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“…This finding emphasized the importance of ensuring that infants are exposed to sufficient auditory exposure through early life. A previous study suggested that the hemispheric asymmetry pattern for auditory information processing was associated with the severity of hearing impairment in adults (Zhu et al 2020). Subcortical disease studies have suggested that interhemispheric asymmetry is related to the degree of clinical impairment in adults, such as ischemic stroke (Fanciullacci et al 2017).…”

Section: Lack Of Auditory Exposure In Early Life Affects Brain Develo...mentioning

confidence: 98%

Developmental Alterations in Brain Network Asymmetry in 3- to 9-Month Infants with Congenital Sensorineural Hearing Loss

Liu

Zhou

et al. 2023

Preprint

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Auditory exposure plays crucial roles in shaping healthy brain development and generating lateralization of functional network organization. However, little is known about whether and how an initial lack of auditory exposure in early infancy may disrupt development of functional network lateralization. We addressed this issue by recruiting 55 infants with congenital sensorineural hearing loss (SNHL) and 60 typically developing (TD) controls. Resting-state fNIRS imaging data were acquired to construct hemispheric cerebral networks, and graph theory was applied to quantify the topological characteristics of hemispheric networks. The infants with SNHL exhibited efficient small-world characteristic within each hemispheric network, however, the lateralization of functional network efficiency was substantially disrupted. Compared with TD infants with significantly increased network efficiency lateralized toward left hemisphere with age, the SNHL infants did not exhibit the emergence and development of such cerebral lateralization. Furthermore, the increased leftward asymmetry in nodal efficiency with age was found in TD but not in SNHL infants. Interestingly, the degree of hearing loss had no correlation with lateralization strength in the SNHL group. These results suggest that SNHL infants exhibited disrupted development of cortical lateralization in functional network organization, and highlight the importance of auditory stimulation-promoted multisensory functional integration in early infancy.

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“… 10 In a study of patients with long-term hearing impairment, fALFF values were significantly elevated in the temporal and insular lobes, confirming that brain regions within different functional networks were involved in brain remodelling. 11 DC theory explores global brain connectivity, and voxels with high DC values are considered brain hubs. The DC density in the middle frontal gyrus (MFG) was significantly decreased in elderly individuals with hearing loss, which reflects disorders of the brain centre leading to a decrease in higher-order cognitive levels mediated by the frontal lobe.…”

Section: Introductionmentioning

confidence: 99%

Neurovascular coupling dysfunction associated with cognitive impairment in presbycusis

Xing,

Feng,

Yao

et al. 2024

Brain Communications

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The neuropathological mechanism underlying presbycusis remains unclear. This study aimed to illustrate the mechanism of neurovascular coupling associated with cognitive impairment in patients with presbycusis. We assessed the coupling of cerebral blood perfusion with spontaneous neuronal activity by calculating the correlation coefficients between cerebral blood flow and blood oxygen level-dependent-derived quantitative maps (amplitude of low-frequency fluctuation, fractional amplitude of low-frequency fluctuation, regional homogeneity, degree centrality). Four neurovascular coupling metrics (cerebral blood flow-amplitude of low-frequency fluctuation, cerebral blood flow-fractional amplitude of low-frequency fluctuation, cerebral blood flow-regional homogeneity and cerebral blood flow-degree centrality) were compared at the global and regional levels between the presbycusis group and the healthy control group, and the intrinsic association between the altered neurovascular coupling metrics and the neuropsychological scale was further analysed in the presbycusis group. At the global level, neurovascular coupling was significantly lower in the presbycusis group than in the control group and partially related to cognitive level. At the regional level, neurovascular biomarkers were significantly elevated in three brain regions and significantly decreased in one brain region, all of which involved the Papez circuit. Regional neurovascular coupling provides more information than global neurovascular coupling, and neurovascular coupling dysfunction within the Papez circuit has been shown to reveal the causes of poor cognitive and emotional responses in age-related hearing loss patients.

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Brain Functional Alterations in Long-term Unilateral Hearing Impairment

Cited by 5 publications

References 43 publications

Altered regional activity and connectivity of functional brain networks in congenital unilateral conductive hearing loss

Altered regional activity and connectivity of functional brain networks in congenital unilateral conductive hearing loss

Developmental Alterations in Brain Network Asymmetry in 3- to 9-Month Infants with Congenital Sensorineural Hearing Loss

Neurovascular coupling dysfunction associated with cognitive impairment in presbycusis

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