Brain glutathione reductase induction increases early survival and decreases lipofuscin accumulation in aging frogs

López-Torres, Mónica; Pérez‐Campo, R.; Fernández, Alberto; Barba, Carlos; Quiroga, G. Barja de

doi:10.1002/jnr.490340211

Cited by 32 publications

(11 citation statements)

References 46 publications

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“…Furthermore, the consumption of green tea has no apparent effect on lipofuscin accumulation in the prostate, a marker of chronic, generalized oxidative stress (Lopez-Torres et al 1993;Morrissey et al 2002), this is not surprising as the green tea extract appears to have no effect on lipid peroxidation in the seminal vesicles and prostate.…”

Section: Discussionmentioning

confidence: 99%

The effect of green tea on oxidative damage and tumour formation in Lobund–Wistar rats

O'Sullivan

Sheridan

Mulcahy

et al. 2008

European Journal of Cancer Prevention

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A number of epidemiological studies suggest that the consumption of green tea reduces the incidence of prostate cancer. Since the major catechins present in green tea are potent anti-oxidants, we hypothesized that genetic and cellular damage induced by oxygen free radicals could be significantly reduced by potent anti-oxidants in green tea, thus reducing the cumulative genetic and cellular damage with age, and slowing or preventing tumour formation. Long-term administration of a decaffeinated green tea extract to Lobund-Wistar rats for periods up to 26 months almost halved the incidence of primary tumours in the genitourinary tract when compared to an aged-matched cohort receiving just water. We observed no inhibition of DNA adduct formation or lipid peroxidation in animals consuming green tea compared to animals consuming de-ionized water. The decrease in tumour formation was associated with an increase in 8-hydroxy-2’deoxyguanosine (8-OH-dG) and 4-hydroxynonenal (4-HNE) content (markers of DNA adduct formation and lipid peroxidation respectively) in the epithelium of the ventral prostate in aging animals. There was also an increase in 8-OH-dG expression, but no change in 4-HNE expression in the seminal vesicles of older animals. There was an age associated increase in expression of the anti-oxidant enzymes MnSOD and catalase in the epithelium of the ventral prostate of aging animals. There was also an increase in MnSOD expression, but no change in catalase expression in the seminal vesicles of older animals. These data demonstrate that consumption of green tea decreases the incidence of genitourinary tract tumours in the Lobund-Wistar rat, but has no effect on age associated DNA adduct formation and lipid peroxidation in the aging rat ventral prostate and seminal vesicles.

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Section: Discussionmentioning

confidence: 99%

The effect of green tea on oxidative damage and tumour formation in Lobund–Wistar rats

O'Sullivan

Sheridan

Mulcahy

et al. 2008

European Journal of Cancer Prevention

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“…Guinea pig is a usefull model for these studies since they are not capable-like human beings-to synthesize ascorbate. On the other hand, previous studies in both vertebrates (5,6) and invertebrates (4) have shown that cellular antioxidants are subject to homeostatic control: if the animals are exposed to an oxidative stress in vivo, they react with compensatory inductions of endogenous antioxidants . Thus, it is possible that the reverse situation also takes place: increasing the levels of vitamin C (an antioxidant) can promote a reactive depression of endogenous antioxidants.…”

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confidence: 99%

Effect of Vitamin C on Antioxidants, Lipid Peroxidation, and GSH System in the Normal Guinea Pig Heart.

Rojas¹,

Cadenas²,

Pérez‐Campo³

et al. 1994

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryMale guinea pigs were fed during 5 weeks with diets differing only in vitamin C content: low (33mg/kg diet), medium (660 mg/kg), and high (13,200mg/kg). Heart vitamin C was strongly depend ent on dietary vitamin C and heart vitamin E showed a trend to increase as a function of the vitamin C level in the diet. The low vitamin C diet decreased body weight gain, food intake, and heart malondialdehyde without changing lipid peroxidation, whereas the high vitamin C in creased oxidized glutathione and glutathione peroxidase and decreased body growth. A tendency to show higher levels of all the first-line antioxidants reduced glutathione, uric acid, superoxide dismutase, cata lase, and glutathione peroxidase at extreme (high or low) dietary levels of vitamin C was observed. The guinea pig heart showed capacity for enzymatic but not for non-enzymatic in vitro lipid peroxidation. It is concluded that dietary vitamin C supplementation is able to increase the global antioxidant capacity of the heart tissue.

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“…Moreover, lipofuscins also consist of AGE adducts (Horie et al, 1997). Circumstantial evidence indicating a reciprocal relationship of antioxidant and lipofuscin levels highlight the role of oxidative stress in the process of lipofuscin accumulation (Dowson et al, 1992;Lopez-Torres et al, 1993;Gao et al, 1994). Thus, lipofuscins can be regarded as oxidative stress-derived lipid, carbohydrate and protein condensation polymers.…”

Section: Ageing and Redox Homeostasismentioning

confidence: 97%

A unifying hypothesis of Alzheimer's disease. I. Ageing sets the stage

Heininger

1999

Hum. Psychopharmacol. Clin. Exp.

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In a series of ®ve papers, evidence from neurobiology, endocrinology and immunology is integrated into a holistic, coherent hypothesis accommodating genetic, medical and environmental risk factors into a cascade of pathophysiological events that leads to the clinical manifestation of Alzheimer's disease (AD). The perturbation of the calcium-energy-oxidative stress triangle emerges as pathophysiological leitmotif of ageing and AD. Cellular Ca 2 homeostasis and energy metabolism are closely interdependent. Ca 2 ions regulate the activity of a variety of ratelimiting enzymes of the tricarboxylic acid cycle and respiratory chain. Under physiological circumstances, the supply of energy according to demand is regulated by Ca 2 cycling across mitochondrial membranes. In certain pathological conditions, Ca 2 uncouples electron transfer and oxidative phosphorylation and increases the mitochondrial production of oxygen radicals which in tandem with Ca 2 precipitate the breakdown of mitochondrial function and structure. As most important risk factor, ageing sets the stage for the development of AD. The delicate regulation of the neuroendocrine network which physiologically modulates the Ca 2 -energy-redox homeostasis, deteriorates in ageing, compromising the hormonal balance between neurotrophic/protective and neuroaggressive factors. Thus, levels and/or signal transduction pathways of neurotrophic-factors such as neuropeptide Y, neurotrophins, DHEA/ DHEAS, gonadal hormones, melatonin, insulin, insulin-like growth factors, somatostatin, thyroid hormones, and substance P decay, paralleled by the compromise of the hypothalmic-pituitary-adrenal (HPA)-axis feedback inhibition leading to a hyperresponsiveness to stress and a loss of diurnal rhythm of secretion of neuroaggressive glucocorticoids. Both add up to disrupt Ca 2 and energy homeostasis, put the nerve cells under metabolic and oxidative stress and lead to a compromise of neuronal excitability, signal transduction processes and neuronal plasticity. Subject to the same endocrinological dysregulation, the ageing immune system exhibits a primitive response pattern with impairment of speci®c cellular and activation of unspeci®c humoral and microglial immune responses. Thus, the ageing-related concerted perturbation of the homeostatic control in the neuroendocrinoimmunological network creates phenomena which in many aspects are qualitatively similar to changes in AD and lay the foundations for the development of the disease.

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Brain glutathione reductase induction increases early survival and decreases lipofuscin accumulation in aging frogs

Cited by 32 publications

References 46 publications

The effect of green tea on oxidative damage and tumour formation in Lobund–Wistar rats

The effect of green tea on oxidative damage and tumour formation in Lobund–Wistar rats

Effect of Vitamin C on Antioxidants, Lipid Peroxidation, and GSH System in the Normal Guinea Pig Heart.

A unifying hypothesis of Alzheimer's disease. I. Ageing sets the stage

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