Brain gray matter phenotypes across the psychosis dimension

Ivleva, Elena I.; Bidesi, Anup S.; Thomas, Binu P.; Meda, Shashwath A.; Francis, Alan; Moates, Amanda F.; Witte, Bradley; Keshavan, Matcheri S.; Tamminga, Carol A.

doi:10.1016/j.pscychresns.2012.05.001

Cited by 56 publications

(48 citation statements)

References 109 publications

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“…In the first of these 24, which was carried out on small numbers of subjects (<20 in each group), the patients with schizophrenia and schizoaffective disorder, but not the patients with bipolar disorder showed volume reductions compared to healthy controls; the changes also appeared to be considerably more extensive in the patients with schizophrenia than the patients with schizoaffective disorder. The second, much larger, study 25 had findings similar to ours: 146 patients with schizophrenia and 90 patients with schizoaffective disorder showed gray matter volume reductions compared to 200 healthy controls in numerous and overlapping areas, whereas changes in 115 patients with psychotic bipolar disorder were restricted to a single cluster in the frontotemporal cortex.…”

Section: Discussionmentioning

confidence: 99%

“…In the first of these, Ivleva et al. 24 examined 19 patients with schizophrenia, 16 with schizoaffective disorder, and 17 with bipolar psychotic disorder, as well as 10 healthy controls. They found decreased gray matter volume in the patients with schizophrenia, and there were similar, albeit less extensive, changes in the patients with schizoaffective disorder; however, the patients with bipolar disorder did not differ from the controls.…”

Section: Introductionmentioning

confidence: 99%

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Brain structural changes in schizoaffective disorder compared to schizophrenia and bipolar disorder

Amann

Canales‐Rodríguez

Madre

et al. 2015

Acta Psychiatr Scand

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ObjectiveBrain structural changes in schizoaffective disorder, and how far they resemble those seen in schizophrenia and bipolar disorder, have only been studied to a limited extent.MethodForty‐five patients meeting DSM‐IV and RDC criteria for schizoaffective disorder, groups of patients with 45 matched schizophrenia and bipolar disorder, and 45 matched healthy controls were examined using voxel‐based morphometry (VBM).ResultsAnalyses comparing each patient group with the healthy control subjects found that the patients with schizoaffective disorder and the patients with schizophrenia showed widespread and overlapping areas of significant volume reduction, but the patients with bipolar disorder did not. A subsequent analysis compared the combined group of patients with the controls followed by extraction of clusters. In regions where the patients differed significantly from the controls, no significant differences in mean volume between patients with schizoaffective disorder and patients with schizophrenia in any of five regions of volume reduction were found, but mean volumes in the patients with bipolar disorder were significantly smaller in three of five.ConclusionThe findings provide evidence that, in terms of structural gray matter brain abnormality, schizoaffective disorder resembles schizophrenia more than bipolar disorder.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Brain structural changes in schizoaffective disorder compared to schizophrenia and bipolar disorder

Amann

Canales‐Rodríguez

Madre

et al. 2015

Acta Psychiatr Scand

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“…In these studies, SCZ and BD were compared between each other and to HC, as well as to schizoaffective disorder (SAD) patients in Ivleva et al (2012Ivleva et al ( , 2013; Amann et al (2016), and to their firstdegree relatives in Ivleva et al (2013). It is worth noticing that Yüksel et al (2012) included SAD patients in the SCZ group.…”

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confidence: 99%

“…Some studies reported lower GM volume in SCZ than in BD in the temporal lobe, mainly in insula and temporal gyri (McDonald et al 2005;Ivleva et al 2013;Nenadic et al 2015a, b). A few works also reported occipito-parietal deficits associated with SCZ, mainly in lingual gyrus and precuneus (McDonald et al 2005;Ivleva et al 2012), as well as deficits in cingulum (Ivleva et al 2013) and subgenual cortex (Yuksel et al 2012). The widespread GM deficits emerged from these studies may be related to the lower WM metabolism in frontal, parietal and temporal areas characterising SCZ in comparison with BD (Altamura et al 2013).…”

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confidence: 99%

Neuroanatomical voxel-based profile of schizophrenia and bipolar disorder

Maggioni

Altamura

Brambilla

2016

Epidemiol Psychiatr Sci

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This Section of Epidemiology and Psychiatric Sciences appears in each issue of the Journal to stress the relevance of epidemiology for behavioral neurosciences, reporting the results of studies that explore the use of an epidemiological approach to provide a better understanding of the neural basis of major psychiatric disorders and, in turn, the utilisation of the behavioural neurosciences for promoting innovative epidemiological research.The ultimate aim is to help the translation of most relevant research findings into every-day clinical practice. These contributions are written in house by the journal's editorial team or commissioned by the Section Editor (no more than 1000 words, short unstructured abstract, 4 key-words, one Table or Although schizophrenia (SCZ) and bipolar disorder (BD) share elements of pathology (Ellison-Wright and Bullmore, 2009), the neural mechanisms underlying these disorders are still under investigation. Up until now, many neuroimaging studies investigated the brain structural differences of SCZ and BD compared with healthy controls (HC), trying to identify the possible neuroanatomical markers for the two disorders. However, just a few studies focused on the brain structural changes between the two diagnoses. The present review summarises the findings of the voxel-based grey matter (GM) comparisons between SCZ and BD, with the objective to highlight the possible consistent anatomical differences between the two disorders. While the comparisons between patients and HC highlighted overlapping areas of GM reduction in insula and anterior cingulate cortex, the SCZ-BD comparisons suggest the presence of more generalised GM deficits in SCZ compared with BD. Indeed, in a number of studies, SCZ patients showed lower GM volumes than BD patients in fronto-temporal cortex, thalamus, hippocampus and amygdala. Conversely, only a couple of studies reported GM deficits in BD compared with SCZ, both at the level of cerebellum. In summary, the two disorders exhibit both common and specific neuroanatomical characteristics, whose knowledge is mandatory to develop innovative diagnostic and treatment strategies. (Email: marcella.bellani@univr.it; paolo.brambilla1@unimi.it)Epidemiology and Psychiatric Sciences (2016), 25, 312-316.

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“…A shared aetiology between schizophrenia and bipolar disorder with psychosis is supported by findings from genetic (Lee et al), neuropsychological (Hill et al, 2013), phenomenological , structural (Ivleva et al, 2012) and functional neuroimaging studies (Li et al, 2017). It is important to see if any shared aetiology is reflected in similar, or related patterns of pathophysiology in adolescent-onset cases, where neurodevelopmental processes are likely to operate.…”

Section: Introductionmentioning

confidence: 98%