Brain Hypothermia Therapy for Neonatal Hypoxic-Ischemic Encephalopathy With a Severely Elevated Serum Creatine Kinase Level

Kinoshita, Hidetoshi; Imamura, Takashi; Maeda, Hitoshi; Shibukawa, Yasuko; Fukuda, Yutaka; Kin, Shogo; Ariga, Hiromichi; Nagasawa, Katsutoshi

doi:10.5387/fms.2014-30

Cited by 2 publications

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“… 9 , 29 , 30 , 36 There was a case report about an infant that had a very high CK-BB >26.000 IU/L and that developed some neurodevelopmental delay in spite of receiving brain hypothermic therapy. 40 Against our study, Huang et al found a nonsignificant trend for the urinary L/C ratio to increase with the severity of the HIE. 28 …”

Section: Discussioncontrasting

confidence: 65%

Early predictors of brain damage in full-term newborns with hypoxic ischemic encephalopathy

Alkholy

Abdalmonem

Zaki

et al. 2017

NDT

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Objective of the studyTo evaluate the value of serum creatine phosphokinase-brain specific (CK-BB) and urinary lactate/creatinine (L/C) ratio as early indicators of brain damage in full-term newborns with hypoxic ischemic encephalopathy (HIE).Patients and methodsA case–control study including 25 full-term new-born infants with perinatal asphyxia who were admitted to neonatal intensive care unit (NICU) with a proven diagnosis of HIE, compared to 20 healthy age- and sex-matched full-term newborns. All newborn infants were subjected to full history taking, clinical examination, routine investigations (cord blood gases and complete blood picture), and assessment of serum CK-BB (cord blood, 6 and 24 hours after birth) and urinary L/C ratio (collected within the first 6 hours, on the 2nd and 3rd day after birth).ResultsThe serum CK-BB and urinary L/C ratio in infants with HIE were significantly higher in samples collected throughout the monitoring period when compared with the control group (all P<0.001). The cord CK-BB and urinary L/C ratio within the first 6 hours were significantly higher in infants with severe HIE than in infants with mild and moderate HIE (P<0.001). Cord CK-BB level at 12.5 U/L had 100% sensitivity and 84% specificity in the detection of severe HIE infants. Urinary L/C ratio of more than 10.5 collected within the first 6 hours after birth had 100% sensitivity and 78% specificity for the detection of severe HIE infants.ConclusionThe serum CK-BB and urinary L/C ratio in HIE infants were significantly increased early in the course of the disease, which can be used as useful indicators for predicting the development of HIE.

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Section: Discussioncontrasting

confidence: 65%

Early predictors of brain damage in full-term newborns with hypoxic ischemic encephalopathy

Alkholy

Abdalmonem

Zaki

et al. 2017

NDT

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“…Further, as postnatal blood gas is easily corrected by active resuscitation, it may not be possible to correctly evaluate the hypoxemic condition before or soon after birth. Although the elevation of deviation enzymes such as lactate dehydrogenase (LDH), and creatine kinase (CK) has been widely recognized as useful in identifying damaged tissue, 6,7 there are few reports focusing on various blood count indicators related to the severity of fetal distress or neonatal asphyxia. Currently, blood count is frequently used in the diagnosis and followup of blood diseases and infectious diseases, even in neonatal infants.…”

Section: Introductionmentioning

confidence: 99%

Neonatal reticulocyte count during the early postnatal period

Yamada

Chishiki

Kanai

et al. 2020

Pediatrics & Neonatology

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Background: There are few reports on reticulocyte count during the early postnatal period, and its clinical significance is not well understood. To examine the relationships between neonatal reticulocyte count and other perinatal variables. Methods: We conducted a retrospective cohort study of neonatal infants who were admitted to the neonatal intensive care unit (NICU) of Ohta Nishinouchi Hospital, Japan, between April 1, 2016 and July 31, 2019. All blood samples were collected within 3 h after admission. Results: Four hundred and twenty-eight infants were included, of whom 317 (74.1%) were preterm and 111 (25.9%) were term. Two hundred and ninety-nine infants (69.9%) were born by cesarean section. The median reticulocyte counts (&) for all gestational ages (GAs) were as follows: 24e25 wks (n Z 11), 124.1 (range: 106.3 to 148.6); 26e27 wks (n Z 25), 111.1 (range: 55.5 to 144.3); 28e30 wks (n Z 52), 81.9 (range: 35.6 to 131.5); 31e33 wks (n Z 86), 71.6 (range: 28.3 to 116.6); 34e36 wks (n Z 143); 59.6 (range: 30.2 to 110.9); and 37e41 wks (n Z 111), 43.2 (range: 21.9 to 69.2). There were significant relationships between the neonatal reticulocyte count and gender [p < 0.01, odds ratio (OR), 0.37; 95% confidence interval (CI), 0.21 to 0.64], GA (p < 0.01, OR, 0.92; 95% CI, 0.90 to 0.93), delivery type (p Z 0.03, OR, 0.51; 95% CI, 0.28 to 0.95), maternal haemoglobin before delivery (p < 0.01, OR, 0.74; 95% CI, 0.60 to 0.91), tracheal intubation at resuscitation (p Z 0.04, OR, 2.75; 95% CI, 1.04 to 7.32) and mean platelet volume (p < 0.01, OR, 0.51; 95% CI, 0.35 to 0.74). Conclusion: A higher neonatal reticulocyte count in NICU infants may be one of the physiological responses to a more rapid environmental change during the early postnatal period.

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Brain Hypothermia Therapy for Neonatal Hypoxic-Ischemic Encephalopathy With a Severely Elevated Serum Creatine Kinase Level

Cited by 2 publications

References 13 publications

Early predictors of brain damage in full-term newborns with hypoxic ischemic encephalopathy

Early predictors of brain damage in full-term newborns with hypoxic ischemic encephalopathy

Neonatal reticulocyte count during the early postnatal period

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