Brain lipoma, corpus callosum hypoplasia and polymicrogyria in Familial Multiple Lipomatosis

Interhemispheric Lipoma, Callosal Anomaly, and Malformations of Cortical Development: A Case Series

“…Furthermore, the MRI of this infant also showed infratentorial abnormalities, suggestive of a more complex etiology in this infant, and indeed a deletion (5p15.33p15.31) was found with the SNP array. To the best of our knowledge, there has only been one case with an interhemispheric lipoma, callosal hypoplasia, and polymicrogyria in familial lipomatosis, 4 and no case with interhemispheric lipoma and heterotopias. Taking into account the high frequency of interhemispheric lipoma among intracranial lipomas, the occurrence of MCD in cases with interhemispheric lipoma may be less common, compared with those in cases with sylvian or temporal gyral lipomas.…”

“…Intracranial lipomas are rare congenital malformations, which are composed of adipose tissue and are considered to be a result from the abnormal persistence and maldifferentiation of the primitive embryonic meninx, the mesenchymal precursor of the leptomeninges, during development of the subarachnoid cisterns. [1][2][3][4] Common locations of intracranial lipomas include the deep interhemispheric fissure, quadrigeminal cistern, prepontine cistern, and sylvian cistern. 3,5 They are rarely found on the surface of the cerebral cortex.…”

A case of multiple lipomas coexisting with angiolipomas: Familial multiple lipomatosis or a distinct entity?

“…Celiac disease and cytophagic histiocytic panniculitis have been reported in patients with familial multiple lipomatosis [4,5]. Recently, Nunes et al described a female patient who had brain lipoma, corpus callosum hypoplasia, polymicrogyria and familial multiple lipomatosis [6]. In addition, Madelung's disease, Dercum`s disease, Bannayan-Zonana syndrome and Cowden syndrome clinically present with subcutaneous lipomas.…”

Gastroduodenal Lipomatosis in Familial Multiple Lipomatosis

“…Gastrointestinal lipomas associated with FML like this case are very rare, with only 9 cases having been reported, namely, colonic lipoma [3] , intestinal lipoma [4,5] , and brain and cardiac lipoma [6,7] . Our case is similar to that in Bilgic et al [3] , which is a report on a patient with multiple gastroduodenal lipomas associated with abdominal visceral adiposity and a solitary, subcutaneous lipoma on his neck; the patient's father had mobile, nontender, sub- Color version available online cutaneous lesions, with no evidence of gastrointestinal lipomas [3] .…”