Brain Natriuretic Peptide Levels and Cardiac Functional Capacity in Patients With Dyspnea and Isolated Diastolic Dysfunction

Abstract

SUMMARYDiastolic heart failure affects approximately 40%-50% of patients presenting with signs and symptoms of heart failure. The aim of this study was to investigate the relationship between brain natriuretic peptide (BNP) levels and functional capacity in patients admitted with dyspnea and diagnosed with isolated diastolic dysfunction.Fifty-four patients (mean age, 57.4 ± 8.5 years) with class-2 dyspnea with isolated diastolic dysfunction were enrolled. Serum levels of BNP were measured, and peak oxygen consumption (peak VO 2 ), anaerobic threshold (AT), and metabolic equivalent (MET) values were determined with a cardiopulmonary exercise test (CPET).There was a negative correlation between BNP levels and exercise duration (P < 0.05, r = -0.304), AT (P < 0.05, r = -0.380), and number of MET (P < 0.05, r = -0.322) determined by CPET. When patients were divided into 2 groups according to BNP levels; BNP ≤ 50 pg/mL (n = 40) versus BNP > 50 pg/mL (n = 14) and analyzed, those with BNP levels > 50 pg/mL had lower peak VO 2 (P = 0.05) and anaerobic threshold (P = 0.01) compared with patients with BNP ≤ 50 pg/mL.The results suggest that BNP levels provide an indication about the functional capacity determined by CPET in patients admitted with dyspnea and isolated diastolic dysfunction. (Int Heart J 2007; 48: 97-106) Key words: Diastolic dysfunction, Brain natriuretic peptide, Cardiopulmonary exercise test HEART failure (HF) is an important cause of mortality and morbidity worldwide.1) Its prevalence increases as the age of the population increases. Approximately 40%-50% of HF patients have diastolic HF with preserved left ventricular systolic function. 2)Dyspnea is one of the most common symptoms of patients admitted to emergency, cardiology, and pulmonary facilities. It is sometimes difficult for a physiFrom the

Beneficial Effects of Pitavastatin, a 3-Hydroxy-3-Methylglutaryl Coenzyme a Reductase Inhibitor, on Cardiac Function in Ischemic and Nonischemic Heart Failure

“…The study by Serpil, et al revealed that plasma BNP levels provided an indication about the cardiac functional capacity in patients admitted with diastolic dysfunction. 20) Considering these results, we speculate that pitavastatin may improve signs and symptoms of HF.…”

Comparative Analysis of Systolic and Isolated Diastolic Dysfunction Sado Heart Failure Study

“…Also, we did not measure brain natriuretic peptide, the level of which has been recently shown to be indicative of the severity of IDD. 22) Besides being cross-sectional, this study was not a prospective population-based randomized investigation, but rather a retrospective observational study of individuals presenting to outpatient clinics; therefore, the potential for selection bias cannot be excluded. However, besides the aforementioned unique geo-demographic characteristic of the study area, this work was performed at 2 large community-based hospitals, thus this sample may largely represent the typical population with cardiac dysfunction seen by a general practitioner.…”

Effects of right ventricular dysfunction on exercise capacity and quality of life and associations with serum NT-proBNP levels in COPD: an observational study

“…Kruger et al (34) have also found negative correlation between serum BNP level with PVO 2 and AT values in 70 patients with congestive heart failure. Eroğlu et al (35) evaluated the relationship between BNP levels and CPET parameters in patients with dyspnea and isolated left ventricle diastolic dysfunction and found negative correlation between BNP levels and duration of exercise, AT VO 2 , and MET on CPET. To the best of our knowledge, this is the first study using CPET, and BNP levels in COPD patients.…”