ÖZETAmaç: Atriyal fibrilasyon (AF) günümüzde en sık gözlenen kalıcı ritim bozukluğu olmasına rağmen hastalığın prevalansı, risk faktörlerinin sıklığı, uygulanan pıhtı önler tedavinin uygunluğu ve başarısı hakkındaki veriler yetersizdir. Biz bu çalışmada, üçüncül bir merkez olan hastanemizdeki kardiyoloji polikliniğimize başvuran hastalarda AF prevalansını, risk faktörlerinin sıklığını ve uygulanan pıhtı önler tedavinin uygunluğunu güncel kılavuzları göz önünde bulundurarak araştırmayı amaçladık. Yöntemler: Hastanemizin kardiyoloji polikliniğine Ocak 2010 -Haziran 2010 tarihleri arasında başvuran ve atriyal fibrilasyonu olan hastalar retrospektif olarak çalışmaya dahil edildi. Hastaların demografik özellikleri, atriyal fibrilasyon klinik sınıflaması, CHA2DS2VASC skorları, aldıkları tedaviler değerlendirildi. Retrospektif olarak son 12 ayda ölçülen INR değerlerine ulaşıldı ve pıhtı önler tedavi başarısı değerlendirildi. Bulgular: Kardiyoloji kliniğimize başvuran 4721 hastanın 432'sinde (%9.1) AF vardı. Hastaların 253'ü (%58.5) kadındı, ortalama yaşı 70.4 yıldı. En sık görülen AF tipi kalıcı AF idi. En sık risk faktörü hipertansiyon idi (%71.9). CHA2DS2VASC skoru 377 hastada (%87.2) ≥2 idi ve mutlak pıhtı önler tedavi endikasyonu olan bu hastaların 254'ü (%67.3) varfarin alıyordu. Kalan hastalardan 1 risk faktörü olan 37 hastanın 16'sı; hiç risk faktörü olmayan 18 hastanın 10'u varfarin almaktaydı. Endike olduğu halde varfarin kullanmayan 123 hastanın 36'sında pıhtı önler tedavinin kontrendike olduğu, 13 hastanın varfarin kullanmayı reddettiği ve 5 hastanın ise tedaviye uyumsuzluk nedeniyle varfarin tedavilerinin kesildiği öğrenildi. Hastaların %15.9'u pıhtı önler tedavi endike olduğu ve bir engel olmadığı halde varfarin kullanmıyordu. International Normalized Ratio (INR) değerlerine ulaşılabilen hastaların %83.5'inde terapötik INR hedefinin sağlandığı saptandı. Sonuç: Çalışmamızda, hastanemiz kardiyoloji polikliniğinde AF tanısı ile takipte olan hastaların önemli bir kısmının güncel kılavuzlara uygun tedavi aldığı ancak hala azımsanmayacak bir hasta grubunda kılavuzların uygun şekilde uygulanmadığı saptanmıştır.
ABSTRACTObjective: Though atrial fibrillation (AF) is the most common sustained arrhythmia permanently; there is not enough data about the prevalence, frequency of risk factors, and adequacy of anticoagulant therapy. We aimed to investigate the prevalence of AF, the frequency of risk factors, adequacy of anticoagulant therapy in patients who were admitted to our outpatient tertiary cardiology clinic according to current guidelines. Methods: Patients, admitted to our Cardiology outpatient clinic between January -June 2010 and had a history of AF were included to the study retrospectively. Patients' demographic findings, clinical AF classification, CHA2DS2VASC scores, treatments the measured INR values in last 12 months retrospectively and the success of anticoagulant therapy were evaluated. Results: Overall, 432 (9.1%) of 4721 patients had AF. Among them 253 (58.5%) patients were female, mean age was 70.4 ...
Objective: During the course of chronic obstructive pulmonary disease (COPD), pulmonary hypertension (PH) and right ventricular (RV) failure may develop due to elevated afterload of the RV. In those patients, exercise capacity is reduced due to pulmonary and cardiac limitations. We investigated relationships between serum N-terminal of proB-type natriuretic peptide (NT-proBNP) and RV functions with exercise capacity and quality of life in patients COPD.Methods: An observational case-control study was conducted. We enrolled 31 moderate and severe COPD patients, and 20 subjects without chronic diseases as control group. Parameters reflecting the right ventricular diastolic and systolic functions by echocardiography along with serum NT-proBNP levels were assessed. Cardiopulmonary exercise testing and Short Form-36 (SF-36) were applied. Results: Serum NT-proBNP levels were higher in COPD patients than control group (p=0.003). Serum NT-proBNP level was found to be related with pulmonary arterial pressure. Serum NT-proBNP levels were negatively correlated with anaerobic threshold oxygen uptake (AT VO 2 ) and peak oxygen uptake (PVO 2 ) values. Early ventricular filling velocity (Em) was lower in COPD patients. Em wave was significantly correlated with O 2 pulse. There was a positive relationship between tricuspid E/A ratio and VO 2 value at AT. SF-36 domains of physical functioning, general health and role limitation due to physical disorder were significantly correlated with AT VO 2 , PVO 2 and O 2 pulse. Conclusion: Exercise limitation may be predicted by assessment of right ventricule functions and NT-proBNP levels and exercise limitation impairs quality of life in COPD patients.
Left internal mammary artery (LIMA) to pulmonary vasculature fistula is a rare complication after coronary artery bypass surgery. In most cases, the duration between bypass grafting and fistula formation ranges from 2 to 5 years. We present a 62-year-old man who presented with anginal symptoms five years after bypass surgery. On coronary angiography, selective catheterization of the LIMA showed fistula formation to the pulmonary artery, which probably led to coronary steal syndrome and myocardial ischemia. He underwent surgery and the connection between the LIMA and pulmonary artery was terminated. After surgery, his anginal complaints improved and echocardiography showed improvement in the wall motion abnormality detected before surgery.
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