The frequency of embolic risk factors and adequacy of anti-embolic treatment in patients with atrial fibrillation: a single tertiary center experience

Karaçağlar, Emir; Atar, İlyas; Yetis, Begum; Corut, H.; Ersoy, Burcu; Yılmaz, Kerem; Özin, Bülent; Müderrisoğlu, Haldun

doi:10.5152/akd.2012.123

Cited by 13 publications

(10 citation statements)

References 10 publications

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“…In our study, we found that the Turkish population patients treated with warfarin had 49.5% TTR levels. Karacağlar et al (17) analyzed the patients with AF in a single-center study, and they found that 167 of 202 patients had regular INR monitoring and the TTR levels were 83.5%. However, they had a very small sample size for reflecting Turkish data.…”

Section: Discussionmentioning

confidence: 99%

The awareness, efficacy, safety, and time in therapeutic range of warfarin in the Turkish population: warfarin -tr

Çelik¹,

İzcı²,

Kobat³

et al. 2015

Anatol J Cardiol

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Objective:The awareness, time in therapeutic range (TTR), and safety of warfarin therapy were investigated in the adult Turkish population.Methods:This multicenter prospective study includes 4987 patients using warfarin and involved regular international normalized ratio (INR) monitoring between January 1, 2014 and December 31, 2014. TTR was calculated according to F.R. Roosendaal’s algorithm. Awareness was evaluated based on the patients’ knowledge of warfarin’s affect and food–drug interactions.Results:The mean TTR of patients was 49.52±22.93%. The patients with hypertension (55.3%), coronary artery disease (23.2%), congestive heart failure (24.5%), or smoking habit (20.8%) had significantly lower TTR levels than the others. Of the total number of patients, 42.6% had a mechanical valve, 38.4% had non-valvular atrial fibrillation (AF), and 19% had other indications for warfarin. Patients with other indications had lower TTR levels than those with mechanical valve and non-valvular AF (p=0.018). Warfarin awareness decreased in higher age groups. The knowledge of warfarin’s food–drug interactions was 55%. People with higher warfarin awareness had higher TTR levels. Patients with ≤8 INR monitoring/year had lower TTR levels (46.4±25.3 vs. 51.1±21.3, respectively, p<0.001) and lower awareness (44.6% vs. 60.6%, p<0.001) than patients with ≥8 INR monitoring/year. In this study, 20.1% of the patients had a bleeding event (major bleeding 15.8%, minor bleeding 84.2%) within a year.Conclusion:Both the mean TTR ratios and awareness of the Turkish population on warfarin therapy were found to be low. It was thought that low TTR levels of the Turkish population may be caused by the low awareness of warfarin, warfarin’s food–drug interactions, and high rates of concomitant diseases. (Anatol J Cardiol 2016; 16: 595-600)

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Section: Discussionmentioning

confidence: 99%

The awareness, efficacy, safety, and time in therapeutic range of warfarin in the Turkish population: warfarin -tr

Çelik¹,

İzcı²,

Kobat³

et al. 2015

Anatol J Cardiol

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“…According to the results of the TEKHARF (Cardiac Diseases and Risk Factors in Adults in Turkey) study, the prevalence of AF in our country is 1.25% and its overall morbidity is 6.8/100 person-year (3) It is obvious that AF is a significant health problem in our country. While there are many studies assessing the epidemiological data concerning the use of oral anticoagulant medication in patients with AF (4)(5)(6)(7)(8), single center studies on the anticoagulant therapy and the risk of cerebrovascular event have been conducted in our country (9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Atrial Fibrillation in Turkey: Epidemiologic Registry (AFTER) study design

Ertaş¹,

Kaya²,

Yüksel³

et al. 2013

Anadolu Kardiyol Derg

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Objective: Atrial fibrillation (AF) is an important health problem in Turkey. However, no prospective, multicenter, large trial reflecting national data has been published so far. Therefore, the aim of this study was to follow, analyze and evaluate patients with AF in a large multicenter nation-wide trial. Methods: Two thousand three hundred consecutive patients with AF in their electrocardiogram, reflecting all the population of seven geographical regions of Turkey will be included in the study. The patients will be followed up for two years and death, transient ischemic attack, stroke, systemic thromboembolism, major bleeding, hospitalization will be recorded as the primary end-point. Results: Will be available at the end of the study; preliminary results will be due December 2012. Conclusion: General risk profile of patients with AF, frequency of anticoagulation, frequency of effective treatment and risks of bleeding will be evaluated according to the current guidelines. Major adverse events and their independent predictors will be determined. (Anadolu Kardiyol Derg 2013; 13: 339-43)

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“…These patients have high scores; a score evaluation system using a 9 point scale (9-point score evaluation) defi ned as CHA 2 DS 2 -VASc (cardiac failure, hypertension, age ≥ 75 (doubled), diabetes, stroke (doubled), vascular disease, age 65-74 and sex category [female]) acronym [2]. In our country, the studies conducted on AF, stroke and oral anticoagulant usage are mostly unicenter studies with a limited number of patients and CHA 2 DS 2 -VASc score wasn't included [3][4][5]. Since the multicenter studies have been conducted in western and far eastern populations, they do not refl ect the characteristics of the country [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

The Atrial Fibrillation in Turkey: Epidemiologic Registry (AFTER)

Ertaş

Eren²,

Kaya

et al. 2013

Cardiol J

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years (56% female). Persistent-permanent AF was found to be the most common type of non-valvular AF (78%). The most common comorbid disorder was hypertension (73%). It was found that oral anticoagulant therapy was used by 40% of all patients, 37% of whom had effective INR (2.0-3.0). Upon multivariate analysis, age was found to be the only independent predictor of stroke among the variables' effects on thromboembolic events that created CHA 2 DS 2 -VASc abbreviations (OR 1.026, p < 0.001). Conclusions: These results suggest that stroke risk scores should be thoroughly heeded based on guidelines, and that anticoagulation must be applied according to their guidance. (Cardiol J 2013; 20, 4: 447-452)

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The frequency of embolic risk factors and adequacy of anti-embolic treatment in patients with atrial fibrillation: a single tertiary center experience

Cited by 13 publications

References 10 publications

The awareness, efficacy, safety, and time in therapeutic range of warfarin in the Turkish population: warfarin -tr

The awareness, efficacy, safety, and time in therapeutic range of warfarin in the Turkish population: warfarin -tr

Atrial Fibrillation in Turkey: Epidemiologic Registry (AFTER) study design

The Atrial Fibrillation in Turkey: Epidemiologic Registry (AFTER)

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