Brain Natriuretic Peptide Stimulates Lipid Metabolism through Its Receptor <i>NPR1</i> and the Glycerolipid Metabolism Pathway in Chicken Adipocytes

Hu, Huang; Zhao, Gang; Liu, R. R.; Li, Q. H.; Zheng, Mingyue; Li, S. F.; Zhong, Ling; Zhao, Zhenhua; Wen, Jian-cong

doi:10.1021/acs.biochem.5b00714

Cited by 9 publications

(5 citation statements)

References 35 publications

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“…In addition, the cAMP signaling pathway also plays a significant role in the hepatic fat metabolic process and can activate protein kinase A (PKA) to promote β-oxidation of hepatic fat [32]. Genes associated with these signaling pathways were also particularly common among the differentially expressed ones, such as NPR1 (natriuretic peptide receptor 1), ANGPT2 (angiopoietin 2), and SLC13A5 (sodium-dependent citrate transporter member 5); this study indicated that all of these genes participate in the regulation of fat metabolism [33,34,35]. Sheep needed to mobilize a large amount of energy to respond to the heat stress, which enhanced catabolism and reduced anabolism correspondingly.…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic Analysis Provides Novel Insights into Heat Stress Responses in Sheep

Chu

et al. 2019

Animals

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With the intensified and large-scale development of sheep husbandry and global warming, sheep heat stress has become an increasingly important issue. However, little is known about the molecular mechanisms related to sheep responses to heat stress. In this study, transcriptomic analysis of liver tissues of sheep in the presence and absence of heat stress was conducted, with the goal of identifying genes and pathways related to regulation when under such stress. After a comparison with the sheep reference genome, 440,226,436 clean reads were obtained from eight libraries. A p-value ≤ 0.05 and fold change ≥ 2 were taken as thresholds for categorizing differentially expressed genes, of which 1137 were identified. The accuracy and reliability of the RNA-Seq results were confirmed by qRT-PCR. The identified differentially expressed genes were significantly associated with 419 GO terms and 51 KEGG pathways, which suggested their participation in biological processes such as response to stress, immunoreaction, and fat metabolism. This study’s results provide a comprehensive overview of sheep heat stress-induced transcriptional expression patterns, laying a foundation for further analysis of the molecular mechanisms of sheep heat stress.

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Section: Discussionmentioning

confidence: 99%

Transcriptomic Analysis Provides Novel Insights into Heat Stress Responses in Sheep

Chu

et al. 2019

Animals

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“…As far as we know, only a small number of the pathways involved in preadipocyte differentiation in the chicken have been validated to date, including the AMPK/ACC2 signaling pathway (Gan et al 2015), the MAPK/ATF-2 and TOR/p70 S6 kinase pathways (Yan et al 2013; Jun et al 2014), and the glycerolipid metabolism pathway (Huang et al 2015). In the present study, many well-known pathways associated with different stages of differentiation were identified, including glycerolipid metabolism, mammalian target of rapamycin (mTOR) signaling, PPAR signaling, and MAPK signaling pathways.…”

Section: Discussionmentioning

confidence: 99%

Genome-Wide Analysis of lncRNA and mRNA Expression During Differentiation of Abdominal Preadipocytes in the Chicken

Zhang

Han

et al. 2017

G3 Genes|Genomes|Genetics

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Long noncoding RNAs (lncRNAs) regulate adipogenesis and other processes associated with metabolic tissue development and function. However, little is known about the function and profile of lncRNAs during preadipocyte differentiation in the chicken (Gallus gallus). Herein, lncRNA and mRNA expression in preadipocytes at different stages of differentiation were analyzed using RNA sequencing. A total of 1,300,074,528 clean reads and 27,023 novel lncRNAs were obtained from 12 samples. The number of genes (1336 lncRNAs and 1759 mRNAs; 3095 in total) differentially expressed across various stages declined as differentiation progressed. Differentially expressed genes were found to be involved in several pathways related to preadipocyte differentiation that have been extensively studied, including glycerolipid metabolism, and the mammalian target of rapamycin, peroxisome proliferator-activated receptor, and mitogen-activated protein kinase signaling pathways. To our knowledge, some pathways are being reported for the first time, including the propanoate metabolism, fatty acid metabolism, and oxidative phosphorylation pathways. Furthermore, 3095 differentially expressed genes were clustered into eight clusters, and their expression patterns were determined through K-means clustering. Genes involved in the K2 cluster likely play important roles in preadipocyte differentiation. Six stage-specific modules related to A0 (day 0), A2 (day 2), and A6 (day 6) stages were identified, using weighted coexpression network analysis. Nine central, highly connected .genes in stage-specific modules were subsequently identified, including XLOC_068731, XLOC_022661, XLOC_045161, XLOC_070302, CHD6, LLGL1, NEURL1B, KLHL38, and ACTR6. This study provides a valuable resource for further study of chicken lncRNA and facilitates a better understanding of preadipocyte differentiation in the chicken

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“…In chicken, SREBF1 gene was highly expressed in abdominal adipose tissue (Wang et al, 2010 ) and is involved in fat metabolism in Beijing-You chickens (Fu et al, 2014 ). Expression of NPPB is positively correlated with the abdominal fat weight of Beijing-You chickens (Huang et al, 2015b ).…”

Section: Introductionmentioning

confidence: 99%

Genomic Insights Into the Multiple Factors Controlling Abdominal Fat Deposition in a Chicken Model

Abdalla

Chen²,

Nie³

et al. 2018

Front. Genet.

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Genetic selection for an increased growth rate in meat-type chickens has been accompanied by excessive fat accumulation particularly in abdominal cavity. These progressed to indirect and often unhealthy effects on meat quality properties and increased feed cost. Advances in genomics technology over recent years have led to the surprising discoveries that the genome is more complex than previously thought. Studies have identified multiple-genetic factors associated with abdominal fat deposition. Meanwhile, the obesity epidemic has focused attention on adipose tissue and the development of adipocytes. The aim of this review is to summarize the current understanding of genetic/epigenetic factors associated with abdominal fat deposition, or as it relates to the proliferation and differentiation of preadipocytes in chicken. The results discussed here have been identified by different genomic approaches, such as QTL-based studies, the candidate gene approach, epistatic interaction, copy number variation, single-nucleotide polymorphism screening, selection signature analysis, genome-wide association studies, RNA sequencing, and bisulfite sequencing. The studies mentioned in this review have described multiple-genetic factors involved in an abdominal fat deposition. Therefore, it is inevitable to further study the multiple-genetic factors in-depth to develop novel molecular markers or potential targets, which will provide promising applications for reducing abdominal fat deposition in meat-type chicken.

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Brain Natriuretic Peptide Stimulates Lipid Metabolism through Its Receptor NPR1 and the Glycerolipid Metabolism Pathway in Chicken Adipocytes

Cited by 9 publications

References 35 publications

Transcriptomic Analysis Provides Novel Insights into Heat Stress Responses in Sheep

Transcriptomic Analysis Provides Novel Insights into Heat Stress Responses in Sheep

Genome-Wide Analysis of lncRNA and mRNA Expression During Differentiation of Abdominal Preadipocytes in the Chicken

Genomic Insights Into the Multiple Factors Controlling Abdominal Fat Deposition in a Chicken Model

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