Brain serotonin deficiency affects female aggression

Kästner, Niklas; Richter, S. Helene; Urbanik, Sarah; Kunert, Joachim; Waider, Jonas; Lesch, Klaus‐Peter; Kaiser, Sylvia; Sachser, Norbert

doi:10.1038/s41598-018-37613-4

Cited by 27 publications

(14 citation statements)

References 32 publications

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“…Regions such as the cingulate cortex, ventromedial, and the orbitofrontal PFC were shown to have reduced serotonergic activity during impulsive aggression (Siever et al, 1999 ). Similar findings also reproduced in non-human animal models (Harrison et al, 1997 ; Kästner et al, 2019 ; Gorlova et al, 2020 ).…”

Section: Serotonin In Aud and Aggressionsupporting

confidence: 65%

Alcohol, Aggression, and Violence: From Public Health to Neuroscience

et al. 2021

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Alcohol has been associated with violent crimes and domestic violence across many nations. Various etiological factors were linked to chronic alcohol use and violence including psychiatric comorbidities of perpetrators such as personality disorders, mood disorders, and intermittent explosive disorders. Aggression is the precursor of violence and individuals prone to aggressive behaviors are more likely to commit impulsive violent crimes, especially under the influence of alcohol. Findings from brain studies indicate long-term alcohol consumption induced morphological changes in brain regions involved in self-control, decision-making, and emotional processing. In line with this, the inherent dopaminergic and serotonergic anomalies seen in aggressive individuals increase their susceptibility to commit violent crimes when alcohol present in their system. In relation to this, this article intends to investigate the influence of alcohol on aggression with sociopsychological and neuroscientific perspectives by looking into comorbidity of personality or mood disorders, state of the mind during alcohol consumption, types of beverages, environmental trigger, neurochemical changes, and gender differences that influence individual responses to alcohol intake and susceptibility to intoxicated aggression.

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Section: Serotonin In Aud and Aggressionsupporting

confidence: 65%

Alcohol, Aggression, and Violence: From Public Health to Neuroscience

et al. 2021

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“…TPH2 knockout mice exhibited diverse ASD-related behaviors, including impairments in social interaction, an increase in marble burying, and deficient early developmental milestones ( 151 ). Female TPH2 knockout mice exhibited high levels of aggression against co-housed mice and an increase in defensive behavior when paired with a knockout mouse ( 152 ). These studies suggest that prenatal increases and decreases in fetal 5-HT levels may result in the subsequent development of ASD.…”

Section: Prenatal Exposure To Drugsmentioning

confidence: 99%

Influence of Prenatal Drug Exposure, Maternal Inflammation, and Parental Aging on the Development of Autism Spectrum Disorder

et al. 2022

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Autism spectrum disorder (ASD) affects reciprocal social interaction and produces abnormal repetitive, restrictive behaviors and interests. The diverse causes of ASD are divided into genetic alterations and environmental risks. The prevalence of ASD has been rising for several decades, which might be related to environmental risks as it is difficult to consider that the prevalence of genetic disorders related to ASD would increase suddenly. The latter includes (1) exposure to medications, such as valproic acid (VPA) and selective serotonin reuptake inhibitors (SSRIs) (2), maternal complications during pregnancy, including infection and hypertensive disorders of pregnancy, and (3) high parental age. Epidemiological studies have indicated a pathogenetic role of prenatal exposure to VPA and maternal inflammation in the development of ASD. VPA is considered to exert its deleterious effects on the fetal brain through several distinct mechanisms, such as alterations of γ-aminobutyric acid signaling, the inhibition of histone deacetylase, the disruption of folic acid metabolism, and the activation of mammalian target of rapamycin. Maternal inflammation that is caused by different stimuli converges on a higher load of proinflammatory cytokines in the fetal brain. Rodent models of maternal exposure to SSRIs generate ASD-like behavior in offspring, but clinical correlations with these preclinical findings are inconclusive. Hypertensive disorders of pregnancy and advanced parental age increase the risk of ASD in humans, but the mechanisms have been poorly investigated in animal models. Evidence of the mechanisms by which environmental factors are related to ASD is discussed, which may contribute to the development of preventive and therapeutic interventions for ASD.

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“…In the CNS, 5-HT functions to inhibit aggression, thereby controlling domestic behaviors [161][162][163]. The 5-HT deficiency theory of aggression is driven from the negative correlation between the changes of the CNS 5-HT and aggressiveness in humans [164,165], non-human primates [166], rodents [25,167], and chickens [24,168]. Aggressive animals have low levels of 5-HT in the brain, including in the hypothalamus [169][170][171].…”

Section: Serotonin and Aggressionmentioning

confidence: 99%

Gut-Brain Axis: Probiotic,Bacillus subtilis, Prevents Aggression via the Modification of the Central Serotonergic System

Cheng¹,

Jiang²,

Hu³

2019

Oral Health by Using Probiotic Products

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Intestinal bacteria release various neuroactive compounds directly or indirectly regulating brain function to modulate host health and behavior through the gut-brain axis. Probiotics have been used as dietary supplements to target gut microbiota (microbiome) for prevention or therapeutic treatment of various diseases including mental disorders. In our study, chickens were used as an animal model to assess, if dietary supplementation of probiotic, Bacillus subtilis, reduces aggressive behaviors following social challenge. Chickens of an aggressive line were housed in single-hen cages. At 24 weeks of age, the hens were paired with similar body weight to identify the dominance rank (day 0). The subordinate and dominant of each pair were fed a regular layer diet or the diet mixed with 250 ppm probiotics for 2 weeks, then the second behavior test was performed between the same pair (day 14). The display of aggressive behaviors in the regular diet-fed chickens was not affected between the levels at day 0 and day 14, while the frequency of threat and aggressive pecking were reduced in the probiotic-fed chickens compared to the levels at day 0. These results suggest dietary probiotic, Bacillus subtilis, could be a suitable strategy for increasing hosts' mental health.

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Brain serotonin deficiency affects female aggression

Cited by 27 publications

References 32 publications

Alcohol, Aggression, and Violence: From Public Health to Neuroscience

Alcohol, Aggression, and Violence: From Public Health to Neuroscience

Influence of Prenatal Drug Exposure, Maternal Inflammation, and Parental Aging on the Development of Autism Spectrum Disorder

Gut-Brain Axis: Probiotic,Bacillus subtilis, Prevents Aggression via the Modification of the Central Serotonergic System

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