Brain SIRT1 Mediates Metabolic Homeostasis and Neuroprotection

Xu, Jing; Jackson, Charlie W.; Khoury, Nathalie; Escobar, Iris; Pérez-Pinzón, Miguel A.

doi:10.3389/fendo.2018.00702

Cited by 118 publications

(86 citation statements)

References 141 publications

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“…In this regard, proteins that modulate histone acetylation pattern could be responsible of many of these neuroprotective effects. SIRT1 has received a great deal of attention, believed to be a modulator of several neuroprotective effects in different therapies and having an important role in memory regulation as well as in other cognitive abilities [25,57]. A marked reduction in hippocampal SIRT1 levels has been described during aging and different neuroprotective strategies (including treatment with different polyphenolic compounds) have been reported to revert this reduction, pointing out this protein as a mediator of their neuroprotective effects [6,[58][59][60].…”

Section: Discussionmentioning

confidence: 99%

Chronic Polyphenon-60 or Catechin Treatments Increase Brain Monoamines Syntheses and Hippocampal SIRT1 LEVELS Improving Cognition in Aged Rats

et al. 2020

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Polyphenolic compounds from green tea have great interest due to its large CONSUMPTION and therapeutic potential on the age-associated brain decline. The current work compares a similar dose regimen of a whole-green-tea extract and catechin in old rats over the course of 36 days. Results showed a significant improvement in visuo-spatial working memory and episodic memory of old rats after polyphenolic compounds administration assessed by behavioral tests. No effects were observed on the age-associated motor coordination decline. Statistically, results were correlated with significant improvements, mainly in hippocampal and striatal noradrenergic and serotonergic systems, but also with the striatal dopaminergic system. Both polyphenolic treatments also reverted the age-associated reduction of the neuroinflammation by modulating protein sirtuin 1 (SIRT1) expression in hippocampus, but no effects were observed in the usual reduction of the histone-binding protein RBAP46/48 protein linked to aging. These results are in line with previous ones obtained with other polyphenolic compounds, suggesting a general protective effect of all these compounds on the age-associated brain decline, pointing to a reduction of the oxidative stress and neuroinflammatory status reduction as the leading mechanisms. Results also reinforce the relevance of SIRT1-mediated mechanism on the neuroprotective effect and rule out the participation of RBAP46/48 protein.

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Section: Discussionmentioning

confidence: 99%

Chronic Polyphenon-60 or Catechin Treatments Increase Brain Monoamines Syntheses and Hippocampal SIRT1 LEVELS Improving Cognition in Aged Rats

et al. 2020

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“…SIRT1 regulates metabolic homeostasis and neuronal aging [ 4 ]. It may also have neuroprotective effects and have a beneficial effect on neurodegenerative diseases such as Parkinson’s and Alzheimer’s diseases [ 5 , 6 , 7 ]. Citicoline raises the level and increases SIRT1 activity in the rat brain, cultured neurons, and in peripheral blood mononuclear cells [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Application of Citicoline in Neurological Disorders: A Systematic Review

et al. 2020

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Citicoline is a chemical compound involved in the synthesis of cell membranes. It also has other, not yet explained functions. Research on the use of citicoline is conducted in neurology, ophthalmology, and psychiatry. Citicoline is widely available as a dietary supplement. It is often used to enhance cognitive functions. In our article, accessible databases were searched for articles regarding citicoline use in neurological diseases. This article has a systemic review form. After rejecting non-eligible reports, 47 remaining articles were reviewed. The review found that citicoline has been proven to be a useful compound in preventing dementia progression. It also enhances cognitive functions among healthy individuals and improves prognosis after stroke. In an animal model of nerve damage and neuropathy, citicoline stimulated regeneration and lessened pain. Among patients who underwent brain trauma, citicoline has an unclear clinical effect. Citicoline has a wide range of effects and could be an essential substance in the treatment of many neurological diseases. Its positive impact on learning and cognitive functions among the healthy population is also worth noting.

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“…SIRT-1 regulates a wide variety of biological functions, including embryonic development, cell differentiation and apoptosis (Borra et al, 2005;Wang et al, 2018a). In AD, the accumulation of Aβ decreases the levels of SIRT-1 in neurons (Donmez and Outeiro, 2013;Jęśko et al, 2017;Xu et al, 2018). In this line, some studies reported that the preventive action of RV is probably related to the modulation of SIRT-1 expression and activity in neurons (Lagouge et al, 2006;Feng et al, 2013).…”

Section: Neuroprotective Effects Of Resveratrol In Alzheimer's Diseasementioning

confidence: 99%

Resveratrol Derivatives as Potential Treatments for Alzheimer’s and Parkinson’s Disease

Arbo

André‐Miral

Nasre-Nasser

et al. 2020

Front. Aging Neurosci.

101

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Neurodegenerative diseases are characterized by the progressive loss of neurons in different regions of the nervous system. Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most prevalent neurodegenerative diseases, and the symptoms associated with these pathologies are closely related to the regions that are most affected by the process of neurodegeneration. Despite their high prevalence, currently, there is no cure or disease-modifying drugs for the treatment of these conditions. In the last decades, due to the need for the development of new treatments for neurodegenerative diseases, several authors have investigated the neuroprotective actions of naturally occurring molecules, such as resveratrol. Resveratrol is a stilbene found in several plants, including grapes, blueberries, raspberries, and peanuts. Studies have shown that resveratrol presents neuroprotective actions in experimental models of AD and PD, however, its clinical application is limited due to its rapid metabolism and low bioavailability. In this context, studies have proposed that structural changes in the resveratrol molecule, including glycosylation, alkylation, halogenation, hydroxylation, methylation, and prenylation could lead to the development of derivatives with enhanced bioavailability and pharmacological activity. Therefore, this review article aims to discuss how resveratrol derivatives could represent viable molecules in the search for new drugs for the treatment of AD and PD.

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Brain SIRT1 Mediates Metabolic Homeostasis and Neuroprotection

Cited by 118 publications

References 141 publications

Chronic Polyphenon-60 or Catechin Treatments Increase Brain Monoamines Syntheses and Hippocampal SIRT1 LEVELS Improving Cognition in Aged Rats

Chronic Polyphenon-60 or Catechin Treatments Increase Brain Monoamines Syntheses and Hippocampal SIRT1 LEVELS Improving Cognition in Aged Rats

Application of Citicoline in Neurological Disorders: A Systematic Review

Resveratrol Derivatives as Potential Treatments for Alzheimer’s and Parkinson’s Disease

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