Brain structural changes in patients in the early stages of multiple sclerosis with depression

Rojas, Juan Ignacio; Sánchez, F; Patrucco, Liliana; Míguez, Jimena; Besada, Cristina; Cristiano, Edgardo

doi:10.1080/01616412.2017.1298279

Cited by 14 publications

(26 citation statements)

References 26 publications

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“…Depression in PwMS is likely to be, in part, a reaction to physical disability, such as problems with balance and walking, [ 34 , 35 ] or other defined MS symptoms such as fatigue [ 36 , 37 ]. Recent studies indicate that an inflammatory component, involving several pro-inflammatory cytokines, such as interferon gamma and tumor necrosis factor alfa may be associated with mood disorders [ 38 ] and that structural brain alterations may also play a role [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

A global view of comorbidity in multiple sclerosis: a systematic review with a focus on regional differences, methodology, and clinical implications

2020

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Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system which is associated with numerous comorbidities. These include cardiovascular disease, psychiatric and neurologic disturbances, restless leg syndrome, migraine, cancer, autoimmune diseases, and metabolic disorders. Comorbid disease is an important consideration for clinicians treating patients with MS; early presentation of comorbidities can obscure or delay MS diagnosis, as well as significantly impacting the disease course. Improved understanding of comorbidities and their emergence in MS populations is important for improving the quality of life and optimizing treatment for patients. Therefore, we evaluated published studies reporting epidemiologic data on comorbidities and their associated impact on disease progression in patients with MS (PwMS). The prevalence of neurologic, cardiovascular, metabolic, and autoimmune comorbidities was elevated in PwMS in general, and furthermore, this adversely affected a broad range of outcomes. Compared with PwMS, cancer rates in people without MS or the general population were lower, which should prompt further studies into the mechanisms of both diseases. Studies were under-represented in many regions owing to the latitudinal gradient of MS and possible underfunding of studies.

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Section: Resultsmentioning

confidence: 99%

A global view of comorbidity in multiple sclerosis: a systematic review with a focus on regional differences, methodology, and clinical implications

2020

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“…14,31 Lesion and GM volume were not significant predictors for depression rank score (data not shown), which is not in line with previous studies reporting higher lesion volume and more severe GM atrophy in DMS compared to nDMS patients. 32,33 This is probably due to differences in sample characteristics (i.e. early or late MS and MS type).…”

Section: Volumetric Differencesmentioning

confidence: 99%

Fronto-limbic disconnection in patients with multiple sclerosis and depression

et al. 2018

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Background:The biological mechanism of depression in multiple sclerosis (MS) is not well understood. Based on work in major depressive disorder, fronto-limbic disconnection might be important. Objective: To investigate structural and functional fronto-limbic changes in depressed MS (DMS) and non-depressed MS (nDMS) patients. Methods: In this retrospective study, 22 moderate-to-severe DMS patients (disease duration 8.2 ± 7.7 years), 21 nDMS patients (disease duration 15.3 ± 8.3 years), and 12 healthy controls underwent neuropsychological testing and magnetic resonance imaging (MRI; 1.5 T). Brain volumes (white matter (WM), gray matter, amygdala, hippocampus, thalamus), lesion load, fractional anisotropy (FA) of fronto-limbic tracts, and resting-state functional connectivity (FC) between limbic and frontal areas were measured and compared between groups. Regression analysis was performed to relate MRI measures to the severity of depression. Results: Compared to nDMS patients, DMS patients (shorter disease duration) had lower WM volume (p < 0.01), decreased FA of the uncinate fasciculus (p < 0.05), and lower FC between the amygdala and frontal regions (p < 0.05). Disease duration, FA of the uncinate fasciculus, and FC of the amygdala could explain 48% of variance in the severity of depression. No differences in cognition were found. Conclusion: DMS patients showed more pronounced (MS) damage, that is, structural and functional changes in temporo-frontal regions, compared to nDMS patients, suggestive of fronto-limbic disconnection.

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“…Thus, the current study examined whether social cognitive abilities are related to other domains that are affected by MS, including mood symptomatology. Depression and anxiety are common in MS (Arnett, Barwick, & Beeney, ; Arnett et al ., ; Boeschoten et al ., ; Butler, Matcham, & Chalder, ; Siegert & Abernethy, ), and each are associated with different features of MS. Depression has been associated with neuropathology (Rojas et al ., ; van Geest et al ., ), cognitive problems (Arnett et al ., ; Feinstein, ) and poor social support (Gay, Vrignaud, Garitte, & Meunier, ), while anxiety has been associated with increased disability levels and progressive disease course (Askari et al ., ), comorbid depressive symptoms (Giordano et al ., ; Hartoonian et al ., ) and female gender (Giordano et al ., ; Théaudin, Romero, & Feinstein, ). However, there is still a significant amount of unexplained variance in the prediction of depression and anxiety in MS.…”

Section: Introductionmentioning

confidence: 99%

Relationship between social cognition and fatigue, depressive symptoms, and anxiety in multiple sclerosis

Genova

Lancaster

Lengenfelder

et al. 2019

Journal of Neuropsychology

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Emerging research indicates that in addition to physical and cognitive deficits, individuals with multiple sclerosis (MS) may also have impairments in social cognition, such as facial affect recognition and Theory of Mind (ToM). However, there is little research into how social cognition impairments relate to other domains in MS, such as mood and fatigue levels. The current study investigated whether social cognitive ability is associated with fatigue, depressive symptoms and anxiety in MS. Twenty-eight individuals with MS completed questionnaires assessing fatigue (Modified Fatigue Impact Scale), depression (Beck Depression Inventory) and anxiety (State-Trait Anxiety Inventory), as well as tasks of facial affect recognition and ToM (Reading the Mind in the Eyes; Strange Stories). Bivariate correlations were run to examine relationships between variables; partial correlations were subsequently used to ascertain whether these relationships persisted after controlling for cognitive ability (measured with the Symbol Digit Modalities Test). The results indicated that worse performance in both facial affect recognition and ToM were associated with higher rates of psychosocial fatigue, depressive symptoms, and anxiety levels; furthermore, these relationships were not explained by participants' cognitive ability. These preliminary results help us better understand the association between social cognitive abilities and other symptoms in MS, including depressive symptomatology, anxiety and fatigue.

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Brain structural changes in patients in the early stages of multiple sclerosis with depression

Abstract: Patients with RRMS and depression had a reduced total brain volume and a significantly increased lesion burden at T2 MR than patients with RRMS without depression.

Cited by 14 publications

References 26 publications

A global view of comorbidity in multiple sclerosis: a systematic review with a focus on regional differences, methodology, and clinical implications

A global view of comorbidity in multiple sclerosis: a systematic review with a focus on regional differences, methodology, and clinical implications

Fronto-limbic disconnection in patients with multiple sclerosis and depression

Relationship between social cognition and fatigue, depressive symptoms, and anxiety in multiple sclerosis

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