Fronto-limbic disconnection in patients with multiple sclerosis and depression

Geest, Quinten van; Boeschoten, Rosa E.; Keijzer, M. J.; Steenwijk, Martijn D.; Pouwels, Petra J. W.; Twisk, Jos W. R.; Smit, Johannes H.; Uitdehaag, Bernard M. J.; Geurts, Jeroen J. G.; Oppen, Patricia van; Hulst, Hanneke E.

doi:10.1177/1352458518767051

Cited by 35 publications

(27 citation statements)

References 37 publications

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“…Thus, the current study examined whether social cognitive abilities are related to other domains that are affected by MS, including mood symptomatology. Depression and anxiety are common in MS (Arnett, Barwick, & Beeney, ; Arnett et al ., ; Boeschoten et al ., ; Butler, Matcham, & Chalder, ; Siegert & Abernethy, ), and each are associated with different features of MS. Depression has been associated with neuropathology (Rojas et al ., ; van Geest et al ., ), cognitive problems (Arnett et al ., ; Feinstein, ) and poor social support (Gay, Vrignaud, Garitte, & Meunier, ), while anxiety has been associated with increased disability levels and progressive disease course (Askari et al ., ), comorbid depressive symptoms (Giordano et al ., ; Hartoonian et al ., ) and female gender (Giordano et al ., ; Théaudin, Romero, & Feinstein, ). However, there is still a significant amount of unexplained variance in the prediction of depression and anxiety in MS.…”

Section: Introductionmentioning

confidence: 99%

Relationship between social cognition and fatigue, depressive symptoms, and anxiety in multiple sclerosis

Genova

Lancaster

Lengenfelder

et al. 2019

Journal of Neuropsychology

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Emerging research indicates that in addition to physical and cognitive deficits, individuals with multiple sclerosis (MS) may also have impairments in social cognition, such as facial affect recognition and Theory of Mind (ToM). However, there is little research into how social cognition impairments relate to other domains in MS, such as mood and fatigue levels. The current study investigated whether social cognitive ability is associated with fatigue, depressive symptoms and anxiety in MS. Twenty-eight individuals with MS completed questionnaires assessing fatigue (Modified Fatigue Impact Scale), depression (Beck Depression Inventory) and anxiety (State-Trait Anxiety Inventory), as well as tasks of facial affect recognition and ToM (Reading the Mind in the Eyes; Strange Stories). Bivariate correlations were run to examine relationships between variables; partial correlations were subsequently used to ascertain whether these relationships persisted after controlling for cognitive ability (measured with the Symbol Digit Modalities Test). The results indicated that worse performance in both facial affect recognition and ToM were associated with higher rates of psychosocial fatigue, depressive symptoms, and anxiety levels; furthermore, these relationships were not explained by participants' cognitive ability. These preliminary results help us better understand the association between social cognitive abilities and other symptoms in MS, including depressive symptomatology, anxiety and fatigue.

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Section: Introductionmentioning

confidence: 99%

Relationship between social cognition and fatigue, depressive symptoms, and anxiety in multiple sclerosis

Genova

Lancaster

Lengenfelder

et al. 2019

Journal of Neuropsychology

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“…Plata-Bello et al found a decrease of amplitude of low-frequency fluctuations (ALFF) in the left inferior frontal gyrus in MS patients, and this area correlated with the gray matter volume of the left inferior parietal lobule (11). van Geest et al found that compared to non-depressed MS patients, depressed MS patients had lower white matter volume ( p < 0.01), decreased fractional anisotropy of the uncinate fasciculus ( p < 0.05), and lower resting-state functional connectivity between the amygdala and the frontal regions ( p < 0.05) (12). Furthermore, the disease duration, fractional anisotropy of the uncinate fasciculus, and the functional connectivity pair could explain 48% of variance in the severity of depression.…”

Section: Introductionmentioning

confidence: 99%

Relapsing-Remitting Multiple Sclerosis Is Associated With Regional Brain Activity Deficits in Motor- and Cognitive-Related Brain Areas

Liu

Hua

et al. 2019

Front. Neurol.

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Objective: To identify the abnormal regional spontaneous brain activity associated with relapsing-remitting multiple sclerosis (RRMS) using fractional amplitude of low-frequency fluctuation (fALFF) analysis and their relationships with clinical features.Methods: A total of 26 RRMS (11 males, 15 females; age, 36.58 ± 10.82 years) and 27 status-matched healthy group (HGs; 12 males, 15 females; age, 35.85 ± 12.05 years) underwent an Expanded Disability Status Scale (EDSS) examination. fALFF was applied to evaluate the abnormal regional brain activity associated with RRMS. Pearson's correlation analysis was applied to calculate the correlations between the signal values of brain areas that exhibited abnormal fALFF values and clinical features. Receiver operating characteristic (ROC) curve was performed to evaluate the sensitivity and specificity of those altered brain areas to distinguish between RRMS and HGs.Results: Compared with HGs, RRMS exhibited higher fALFF in the right cerebellum posterior lobe, left orbitofrontal cortex, left dorsolateral prefrontal cortex, bilateral supplementary motor area, and right fusiform gyrus and lower fALFF values in the left hippocampus and right precuneus. ROC revealed that these areas showed two good and five fair AUC values (0.77 ± 0.03, 0.729~0.822). However, four combinations with more than five brain regions received the same best discriminatory power with a sensitivity of 96.3% and a specificity of 88.5%. EDSS revealed a negative correlation with supplementary motor area (r = −0.395, p = 0.046).Conclusions: RRMS is associated with abnormal regional brain activity deficits of motor- and cognitive-related areas. The fALFF parameter may serve as a potential biological marker to discriminate between the two groups.

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“…In another study performed by van Geest et al [7] on 22 patients with depression and MS, 21 nDMS patients and 12 healthy controls, DMS patients had lower FA than did nDMS patients in the left UF (P = 0.05). These authors also found that DMS patients had lower FA in the left cingulum (P = 0.04) and left UF (P = 0.03) than did healthy controls.…”

Section: Discussionmentioning

confidence: 87%

“…Specific MS pathologies may trigger the onset of depression. In major depressive disorder (MDD), there are several brain abnormalities that have been found, such as frontal and limbic atrophy and decreased FA of the fronto-limbic white matter tracts [7].…”

Section: Introductionmentioning

confidence: 99%

Multiple sclerosis and depressive manifestations: can diffusion tensor MR imaging help in the detection of microstructural white matter changes?

Hassan

Elkholy

Mahmoud

et al. 2019

Egypt J Radiol Nucl Med

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Background: Multiple sclerosis is one of the commonest causes of neurological disability in middle-aged and young adults. Depression in MS patients can compromise cognitive functions, lead to suicide attempts, impair relationships and reduce compliance with disease-modifying treatments. The aim of this study was to investigate and compare the microstructural changes in the white matter tracts of the limbic system in MS patients with and those without depressive manifestations using a diffusion tensor imaging (DTI) technique. Methods: This study included 40 patients who were divided into three groups. Group 1 comprised of 20 patients with relapsing-remitting MS with depressive symptoms and group 2 comprised 10 MS patients without symptoms of depression. The third group is a control group that included 10 age-matched healthy individuals. All patients underwent conventional MRI examinations and DTI to compare the fractional anisotropy (FA) values in the white matter tracts of the limbic system. Results: We compared the DTI findings in MS patients with and those without depressive symptoms. It was found that patients with depression and MS exhibited a significant reduction in the FA values of the cingulum (P < 0.0111 on the right and P < 0.0142 on the left), uncinate fasciculus (P < 0.0001 on the right and P < 0.0076 on the left) and the fornix (P < 0.0001 on both sides). No significant difference was found between the FA values of the anterior thalamic radiations in both groups. Conclusion: Patients with depression and MS showed more pronounced microstructural damage in the major white matter connections of the limbic pathway, namely, the uncinate fasciculus, cingulum and fornix. These changes can be detected by DTI as decreased FA values in depressed MS patients compared to those in non-depressed patients.

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Fronto-limbic disconnection in patients with multiple sclerosis and depression

Cited by 35 publications

References 37 publications

Relationship between social cognition and fatigue, depressive symptoms, and anxiety in multiple sclerosis

Relationship between social cognition and fatigue, depressive symptoms, and anxiety in multiple sclerosis

Relapsing-Remitting Multiple Sclerosis Is Associated With Regional Brain Activity Deficits in Motor- and Cognitive-Related Brain Areas

Multiple sclerosis and depressive manifestations: can diffusion tensor MR imaging help in the detection of microstructural white matter changes?

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