Brain to Belly: Abdominal Variants of Migraine and Functional Abdominal Pain Disorders Associated With Migraine

Lenglart, Léa; Caula, Caroline; Moulding, Thomas; Lyles, Annabel; Wohrer, Delphine; Titomanlio, Luigi

doi:10.5056/jnm20290

Cited by 15 publications

(26 citation statements)

References 127 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…More data are necessary to investigate the prevalence and pathogenesis of RSVS. Given that we observed headaches associated with pain in other parts of the body, such as abdominal variants of migraine [ 14 ] or cardiac cephalalgia [ 15 ], such migraines could be derived from the same pathology as RSVS.…”

Section: Discussionmentioning

confidence: 99%

Reversible Cerebral Vasoconstriction Syndrome Associated with Vasospasm of the Colic Arteries and Possibly Coronary Vasospasm

et al. 2023

View full text Add to dashboard Cite

Objective:Rare disease Background:Reversible cerebral vasoconstriction syndrome (RCVS) is a disorder characterized by recurrent thunderclap headaches and reversible cerebral vasoconstriction. Case Report:Herein, we present the case of a man in his forties with a disease entity related to RCVS accompanied by vasospasm of the extracerebral blood vessels throughout the body. The patient presented to the Emergency Department with a severe headache and epigastric pain. Initially receiving a misdiagnosis of functional pain, he continued to experience severe recurrent headaches, most often after urinating or defecating and was referred to our department. Suspecting RCVS, we performed magnetic resonance angiography, which revealed beaded irregularity in the right anterior cerebral and V4 vertebral arteries. The patient also had epigastric pain that coincided with each headache. Electrocardiography revealed pronounced ST-segment elevation in leads I and aVL and inverted T wave in lead III, while abdominal computed tomography angiography showed narrowing of the colic arteries. We named this disease "reversible systemic vasoconstriction syndrome" (RSVS) as a potential suggested terminology for the future. Conclusions:RSVS is a clinical syndrome characterized by thunderclap headaches and simultaneous unbearable pain in extracerebral organs. To the best of our knowledge, this is the first case report of RCVS with coronary and colic artery vasospasm. We need to take great care of patients with chest or abdominal pain accompanied by recurrent thunderclap headaches, since they can be misdiagnosed with functional or psychogenic disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

Reversible Cerebral Vasoconstriction Syndrome Associated with Vasospasm of the Colic Arteries and Possibly Coronary Vasospasm

et al. 2023

View full text Add to dashboard Cite

show abstract

“…There are also evidences showing correlation between pain related functional gastrointestinal disorders and migraine in pediatric population as well as many evidences based on association of anxiety, depression and functional dyspepsia [27].…”

Section: Discussionmentioning

confidence: 99%

Is there a difference between patients with functional dyspepsia and irritable bowel syndrome in headache manifestation?

et al. 2023

View full text Add to dashboard Cite

Introduction/Objective. The objective was to explore whether there is a difference in headache manifestation and level of its intensity in patients with functional dyspepsia and irritable bowel syndrome. Methods. We assessed a cohort of N=420 participants out of which N=300 satisfied presence of irritable bowel syndrome (148) or functional dyspepsia (152) as a recruiting criterion. Diagnoses of irritable bowel syndrome and functional dyspepsia were made according to Rome IV criteria. Intensity of headaches was estimated in irritable bowel syndrome and functional dyspepsia participants using visual-analog scale. All patients underwent subsequent testing by Hamilton's depression inventory and anxiety scale. Results. Our results showed that males with headaches are more susceptible to functional dyspepsia, statistical significance in the group of patients with irritable bowel syndrome with high scores visual analog scales, in relation of Hamilton?s anxiety scores in the group of patients with irritable bowel syndrome. Gender and visual analogue scale scores were determinants to show whether the patient falls within the group of functional dyspepsia or irritable bowel syndrome. Scores of visual analogue scale where the patient felt the best was statistically borderline (p = 0.061) and its higher values pinpointed which of those patients fall into irritable bowel syndrome group. Conclusion. Gender and level of headache intensity as a extraintestinal manifestation showed to be the main variables to make a difference between patients with functional dyspepsia and irritable bowel syndrome where irritable bowel syndrome had higher scores and greater dominance in differential diagnosis if the headache was determining variable.

show abstract

“…We have investigated the hypothesis that the multifactorial phenomena linking infantile colic and functional dyspepsia with migraine is similar to the association of infantile regurgitation with migraine. The many different pathophysiological pathways of the gut-brain axis have been recently explored in a review, summarising the recent knowledge on abdominal variants of migraine and functional abdominal pain disorders associated with migraine in the paediatric population [ 26 ]. Gastric motility abnormalities, impaired gastric accommodation and visceral hypersensitivity are all related to functional dyspepsia and migraine, and could be key to a better understanding of infantile regurgitation.…”

Section: Discussionmentioning

confidence: 99%

The association between gastro-oesophageal reflux and migraine in the paediatric population: a multicentre case–control study

Lenglart

Raieli²,

Sciruicchio³

et al. 2022

Eur J Pediatr

Self Cite

View full text Add to dashboard Cite

Infantile regurgitation is one of the most common discomforts in the first months of life. Infantile colic and, in older children, functional dyspepsia have been linked to migraine. To date, this is the first study to investigate a possible association between infantile regurgitation and primary headaches in children. This is a case–control study of 195 children aged 6–17 years, with primary headache (migraine, or tension type headache) in 5 European paediatric hospitals. The control group is composed of 240 same-aged children attending with minor injuries during the same period — February 1st 2020 to December 1st 2020. A structured questionnaire identified a history of infantile regurgitation and other functional gastrointestinal disorders for case and control participants. The outcome was the difference in the prevalence of infantile regurgitation among children with or without a diagnosis of primary headache. The analysis showed a significant association between infantile regurgitation and migraine ( OR = 1.88, CI 95 = 1.01–3.4, p = 0.04). No association was found between infantile regurgitation and tension type headache ( p = 0.33). Subgroup analysis confirmed that the association was only significant for migraine without aura ( OR = 2.3, CI 95 = 1.2–4.4, p = 0.01). In a further subgroup analysis, the presence of functional dyspepsia, irritable bowel syndrome and abdominal migraine was associated with migraine without aura. Conclusion: The presence of migraine among children aged 6–17 was associated with a history of infantile regurgitation. Additional longitudinal studies are required to confirm whether infantile regurgitation could be considered as a precursor of migraine. What is Known: • Children suffering from functional gastrointestinal disorders are more likely to be suffering from migraine and tension-type headache as well. • Children suffering from primary headache are more likely to have had infantile colic in their first six month of life . What is New: • It is the first study to find an association between migraine and infantile regurgitation in children. • These findings could have an impact on the diagnosis and therapeutics of both migraine and infantile regurgitation. Supplementary information The online version contains supplementary material available at 10.1007/s00431-021-04368-6.

show abstract

Brain to Belly: Abdominal Variants of Migraine and Functional Abdominal Pain Disorders Associated With Migraine

Cited by 15 publications

References 127 publications

Reversible Cerebral Vasoconstriction Syndrome Associated with Vasospasm of the Colic Arteries and Possibly Coronary Vasospasm

Reversible Cerebral Vasoconstriction Syndrome Associated with Vasospasm of the Colic Arteries and Possibly Coronary Vasospasm

Is there a difference between patients with functional dyspepsia and irritable bowel syndrome in headache manifestation?

The association between gastro-oesophageal reflux and migraine in the paediatric population: a multicentre case–control study

Contact Info

Product

Resources

About