Brain uptake of thiamine-coated nanoparticles

Lockman, Paul R.; Oyewumi, Moses O.; Koziara, Joanna M.; Roder, Karen E.; Mumper, Russell J.; Allen, David

doi:10.1016/j.jconrel.2003.08.006

Cited by 234 publications

(115 citation statements)

References 18 publications

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“…Because of their unique physical and chemical properties, nano-materials have great potential use in agriculture, computer, medicine, military and many other areas. Simultaneously, it has been recognized that because of their ultrafine particle size, nano-materials can enter cells or even cross the blood-brain carrier [1][2][3] and cause harm to organisms. Much research has been done to investigate the toxicity of nano-materials on organisms [4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Aqueous stability of oxidized carbon nanotubes and the precipitation by salts

Peng

Jia

Gong

et al. 2009

Journal of Hazardous Materials

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Section: Introductionmentioning

confidence: 99%

Aqueous stability of oxidized carbon nanotubes and the precipitation by salts

Peng

Jia

Gong

et al. 2009

Journal of Hazardous Materials

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“…They also pointed out that physical and chemical properties of NPs lead to an increase of bioavailability and toxicity. On the other hand, NPs can cross the strongest biological barriers such as blood-brain barrier (Lockman et al 2003). Additional to effects of NPs, there are some researches about the action mechanism of NPs on cells.…”

Section: Discussionmentioning

confidence: 99%

“…As by today there is increasing scientific evidence that these physical and chemical properties of manufactured NPs lead to an increase of bioavailability and toxicity (Nel et al 2006). NPs can cross the strongest biological barriers such as the blood-brain barrier (Lockman et al 2003). Oberdörster et al (2005) have outlined three key elements of nanoparticle toxicity screening strategies: physicochemical characterization, in vitro assays (cellular and sub-cellular) and in vivo studies.…”

Section: Introductionmentioning

confidence: 99%

In vitro genotoxic effects of ZnO nanomaterials in human peripheral lymphocytes

et al. 2013

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In this study, possible genotoxic effects of zinc oxide (ZnO) nanoparticles were investigated in cultured human peripheral lymphocytes by using chromosome aberrations and micronucleus assays (MN). For this purpose, the cells were treated with ZnO (1, 2, 5, 10, 15 and 20 lg/mL) for 24 and 48 h. In this research, four types of chromosome aberrations were observed as chromatid and chromosome breaks, fragment and dicentric chromosomes. ZnO induced significant increase of the ratio of chromosomal aberrations as well as percentage of abnormal cells at concentrations of 1, 5, 10 and 20 lg/mL in 24 h treatments. In 48 h treatments, while ZnO nanomaterials induced significant increase of the percentage of abnormal cells only at a concentration of 10 lg/mL, and of chromosome aberration per cell in comparison to the control at concentrations of 5 and 10 lg/mL. On the other hand, this material significantly increased the micronuclei frequency (MN) at concentrations of 10 and 15 lg/mL in comparison to the control. Cytokinesis-block proliferation index was not affected by ZnO treatments. It also decreased the mitotic index in all concentrations at 24 h but not at 48 h. The present results indicate that ZnO nanoparticles are clastogenic, mutagenic and cytotoxic to human lymphocytes in vitro at specific concentrations and time periods.

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“…Very frequently, nanoparticle studies only include evaluation of uptake without separately exploring transport; in these studies, what happens after uptake is left to speculation [41,52,[120][121][122][123][124]. Transport Figure 2 The idea of an all-peptidic nanoplatform would put together the advantages that a peptidic nature can bring to every piece of this nanoplatform, in terms of mild synthetic conditions, potential to modulate the nanoplatform biodistribution, to increase its half-life in blood, and to improve its transport across the BBB.…”

Section: Nanoplatform Characterisationmentioning

confidence: 99%

The role of peptides in blood‐brain barrier nanotechnology

Teixidó

Giralt

2007

Journal of Peptide Science

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Abstract:The blood-brain barrier (BBB) regulates the passage of molecules between the bloodstream and the brain. Overcoming the difficulty of delivery drugs to specific areas of the brain is a major challenge. The BBB exerts a neuroprotective function as it hinders the delivery of diagnostic and therapeutic agents to the brain. Here, we provide an overview of the way in which peptides and nanotechnology are being exploited in tandem to address this problem. Peptides can be used as specialised coatings able to transport nanoparticles with specific properties, such as targeting. The nanoparticle can also carry a peptide drug. Furthermore, peptides can be used in less conventional approaches such as all-peptide nanoparticles. In summary, the combined use of peptides and nanotechnology offers tremendous hope in the treatment of brain disorders.

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Brain uptake of thiamine-coated nanoparticles

Cited by 234 publications

References 18 publications

Aqueous stability of oxidized carbon nanotubes and the precipitation by salts

Aqueous stability of oxidized carbon nanotubes and the precipitation by salts

In vitro genotoxic effects of ZnO nanomaterials in human peripheral lymphocytes

The role of peptides in blood‐brain barrier nanotechnology

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