Brainstem auditory and visual evoked potentials in children with protein-energy malnutrition

Durmaz, Şenay Arıkan; Karagöl, Uur; Deda, Gülhıs; Önal, Mehmet Zülküf

doi:10.1046/j.1442-200x.1999.01150.x

Cited by 19 publications

(12 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The kwashiorkor group had significantly longer mean IPL of the waves I-V than the marasmus group on the right ear and than the control group on the left ear. The kwashiorkor group had also significantly longer mean IPL of the waves III-V than the control group on the left [11]. In the study of Bartel et al [12], ABPs were recorded in a group of 22 children with severe malnutrition (kwashiorkor).…”

Section: Discussionmentioning

confidence: 98%

“…There are limited studies about evaluation of ABPs in children with PEM in the literature, in which all of them showed abnormal ABPs in different degrees in children with malnutrition [9][10][11][12][13]. Durmaz et al [11] studied ABPs in 11 kwashiorkor and 10 marasmus patients and 10 healthy control subjects.…”

Section: Discussionmentioning

confidence: 99%

“…Durmaz et al [11] studied ABPs in 11 kwashiorkor and 10 marasmus patients and 10 healthy control subjects. They found that there were no differences between the mean latencies of the waves I-IV and mean interpeak latencies of the waves I-III of the ABP between the three groups.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Auditory brainstem potentials in children with protein energy malnutrition

Odabaş

Çaksen

Şar

et al. 2005

International Journal of Pediatric Otorhinolaryngology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Auditory brainstem potentials in children with protein energy malnutrition

Odabaş

Çaksen

Şar

et al. 2005

International Journal of Pediatric Otorhinolaryngology

View full text Add to dashboard Cite

“…Several investigators have reported alterations in the developing auditory brainstem pathway to various challenges, including malnutrition, nutritional recovery and environmental stimulation (Roncagliolo et al, 1998; Durmaz et al, 1999; Rocinholi et al, 2001a,b). Malnutrition resulted in increases in ABCT, whereas enriched environments reduced conduction times, i.e., promoting faster nervous impulse transmission.…”

Section: Discussionmentioning

confidence: 99%

Mild carbon monoxide exposure and auditory function in the developing rat

Stockard-Sullivan

Korsak

Webber

et al. 2003

J of Neuroscience Research

View full text Add to dashboard Cite

We have examined the influence of chronic mild exposure to carbon monoxide (CO) on cognitive (learning) and auditory function in the developing rat. We have demonstrated that the auditory pathway is compromised at exposures less than 50 ppm, whereas learning was not influenced at 100 ppm. Artificially reared rat pups were exposed to CO during the brain growth spurt and onset of myelination. Spatial learning was assessed using the Morris Water Maze and three tests of auditory function: (1) auditory brainstem conduction times; (2) the amplitude of the eighth nerve's action potential; and (3) otoacoustic emissions carried out on rat pups (age 22- 24 days). The pups were gastrostomy-reared on a rat milk substitute and chronically exposed to CO at discrete concentrations in the range of 12-100 ppm from 6 days of age to post-weaning at 21-23 days of age. We found no difference in auditory brainstem conduction times at all CO concentrations in comparison to non-exposed controls. There was a difference in otoacoustic emissions for test and controls at CO concentrations of 50 ppm but not at lower concentrations. There was a consistent attenuation of the amplitude of the eighth nerve's action potential, even at the lowest CO exposure examined. The attenuation of the amplitude of the action potential of the eighth nerve at 50 ppm carbon monoxide exposure did not completely recover by 73 days of age. We conclude that prolonged mild exposure to carbon monoxide during development causes measurable functional changes at the level of the eighth cranial nerve.

show abstract

“…Reports of abnormalities in electroencephalography (EEG) patterns [11,12], auditory brainstem potentials [13,14], auditory [15] and visual [14] evoked potential in children raised on a protein-deficient (PD) diet indicate that consumption of PD diet leads to impairments in neuronal activity and sensory processing.…”

Section: Introductionmentioning

confidence: 99%

Physiological Slowing and Upregulation of Inhibition in Cortex Are Correlated with Behavioral Deficits in Protein Malnourished Rats

et al. 2013

View full text Add to dashboard Cite

Protein malnutrition during early development has been correlated with cognitive and learning disabilities in children, but the neuronal deficits caused by long-term protein deficiency are not well understood. We exposed rats from gestation up to adulthood to a protein-deficient (PD) diet, to emulate chronic protein malnutrition in humans. The offspring exhibited significantly impaired performance on the ‘Gap-crossing’ (GC) task after reaching maturity, a behavior that has been shown to depend on normal functioning of the somatosensory cortex. The physiological state of the somatosensory cortex was examined to determine neuronal correlates of the deficits in behavior. Extracellular multi-unit recording from layer 4 (L4) neurons that receive direct thalamocortical inputs and layers 2/3 (L2/3) neurons that are dominated by intracortical connections in the whisker-barrel cortex of PD rats exhibited significantly low spontaneous activity and depressed responses to whisker stimulation. L4 neurons were more severely affected than L2/3 neurons. The response onset was significantly delayed in L4 cells. The peak response latency of L4 and L2/3 neurons was delayed significantly. In L2/3 and L4 of the barrel cortex there was a substantial increase in GAD65 (112% over controls) and much smaller increase in NMDAR1 (12-20%), suggesting enhanced inhibition in the PD cortex. These results show that chronic protein deficiency negatively affects both thalamo-cortical and cortico-cortical transmission during somatosensory information processing. The findings support the interpretation that sustained protein deficiency interferes with features of cortical sensory processing that are likely to underlie the cognitive impairments reported in humans who have suffered from prolonged protein deficiency.

show abstract

Brainstem auditory and visual evoked potentials in children with protein-energy malnutrition

Cited by 19 publications

References 24 publications

Auditory brainstem potentials in children with protein energy malnutrition

Auditory brainstem potentials in children with protein energy malnutrition

Mild carbon monoxide exposure and auditory function in the developing rat

Physiological Slowing and Upregulation of Inhibition in Cortex Are Correlated with Behavioral Deficits in Protein Malnourished Rats

Contact Info

Product

Resources

About