Brainstem auditory evoked response in the diagnosis of pediatric neurologic diseases

Hecox, Kurt; Cone, Barbara; Blaw, Michael E.

doi:10.1212/wnl.31.7.832

Cited by 143 publications

(54 citation statements)

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“…In addition, no patient who was likely to have additional central nervous disorders (specific syndromes, foetal alcohol syndrome, intracranial injury, epilepsy) that might have affected ABR patterns was included in this study (Hecox et al 1981). Children who were found to have additional conductive HL at the time of ABR evaluation and children with a history of recurrent middle-ear effusions were omitted as this influenced ABR development.…”

Section: Participantsmentioning

confidence: 99%

Hearing loss in early infancy affects maturation of the auditory pathway

Tibussek

Meister

Walger

et al. 2002

Develop Med Child Neuro

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The influence of early cochlear hearing loss on maturation of the auditory pathway was studied by measuring auditory brainstem responses (ABR). In a retrospective study, 85 children with normal hearing (46 males, 39 females; age range 2 months to 14 years) and 165 children with binaural cochlear hearing impairment (89 males, 76 females; age range 1 month to 16 years) were examined. A significant positive correlation (p<0.001) between the degree of hearing loss and interpeak latencies I-V (IPL I-V ) of the ABR was observed. No significant correlation (p=0.85) was found between hearing loss and interpeak latencies I-III (IPL I-III ). These findings can be interpreted as indicating a marked delay in maturation of higher brainstem structures due to reduced auditory input during infancy. The correlation differs notably from results of comparable studies of adults published in recent literature. This leads to the assumption that the developing human brain is particularly sensitive to auditory deprivation. Thus, our results indicate the importance of a normal acoustic environment during sensitive periods in early childhood to ensure normal hearing and speech development.

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Section: Participantsmentioning

confidence: 99%

Hearing loss in early infancy affects maturation of the auditory pathway

Tibussek

Meister

Walger

et al. 2002

Develop Med Child Neuro

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“…With the advent of brainstem evoked response audiometry (BERA), detection and quantification of hearing impairment has been easier in pediatric patients who are unable to cooperate with routine testing [6].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Hearing Loss in High Risk Infants of Mediocre Socio-economic Background at Around One Year of Age and Their Correlation with Risk Factors

Mukherjee

Sarkar

2012

Indian J Otolaryngol Head Neck Surg

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The present study tried to determine the hearing threshold by brainstem evoked response audiometry (BERA) in the high-risk infants from a mediocre socioeconomic background at around 1 year of age and correlate different risk factors with hearing loss. BERA was done on 127 infants of 6-18 months age of which 87 were high risk. All were given monaural acoustic stimulus using Cz-M1/ M2 Montage. Based on the appearance of wave V at minimum stimulus intensity, hearing threshold in decibels (dB) of each ear was determined. To study the association of the individual risk factor with hearing loss multiple logistic regression test was applied. Taking BERA threshold for 'Pass' as B40 dBnHL, out of 87 high risk infants 10.34 % (n = 9) had bilateral severe to profound hearing loss, 17.24 % (n = 15) had bilateral mild to moderate hearing loss and 12.64 % (n = 11) had impaired hearing in one ear. All of the control group infants had normal hearing threshold of 30 dBnHL. Twenty major risk factors were identified in the whole study group at an average of 2.3 factors per infant. Twelve factors were examined for correlation using Odd's ratio (OR) with[40 dBnHL threshold as the outcome variable. Factors with very high OR were family history of deafness, Ototoxic drugs and Craniofacial abnormality followed by others. High risk infants have a persistent and definitive risk of hearing loss prompting early intervention.

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“…For example, Hecox et al (1981) stated that for pediatric applications of the auditory brainstem response (ABR), "…increasing rate of stimulation facilitates the identification of [ABR] abnormalities". As late as 2002, the use of high-rate stimuli has been strongly advocated for the ABR when evaluating preterm infants (Jiang et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

The use of QSD (q-sequence deconvolution) to recover superposed, transient evoked-responses

Jewett

Caplovitz

Baird

et al. 2004

Clinical Neurophysiology

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Objective: We describe q-sequence deconvolution (QSD), a new data acquisition/analysis method for evoked-responses that solves the problem of waveform distortion at high stimulus repetitionrates, due to response overlap. QSD can increase the sensitivity of clinically useful evoked-responses because it is well known that high stimulus repetition-rates are better for detecting pathophysiology.Methods: QSD is applicable to a variety of experimental conditions. Because some QSD-parameters must be chosen by the experimenter, the underlying principles and assumptions of the method are described in detail. The theoretical and mathematical bases of the QSD method are also described, including some equivalent computational formulations.Results: QSD was applied to recordings of the human auditory brainstem response (ABR) at stimulus repetition-rates that overlapped the responses. The transient ABR was recovered at all rates tested (highest 160/s), and showed systematic changes with stimulus repetition-rate within a single subject. Conclusions: QSD offers a new method of recovering brain evoked-response activity having a duration longer than the time between stimuli.Significance: The use of this new technique for analysis of evoked responses will permit examination of brain activation patterns across a broad range of stimulus repetition-rates, some never before studied. Such studies will improve the sensitivity of evoked-responses for the detection of brain pathophysiology. New measures of brain activity may be discovered using QSD. The method also permits the recovery of the transient brain waveforms that overlap to form 'steady-state' waveforms. An additional benefit of the QSD method is that repetition-rate can be isolated as a variable, independent of other stimulus characteristics, even if the response is a nonlinear function of rate.

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Brainstem auditory evoked response in the diagnosis of pediatric neurologic diseases

Cited by 143 publications

References 0 publications

Hearing loss in early infancy affects maturation of the auditory pathway

Hearing loss in early infancy affects maturation of the auditory pathway

Prevalence of Hearing Loss in High Risk Infants of Mediocre Socio-economic Background at Around One Year of Age and Their Correlation with Risk Factors

The use of QSD (q-sequence deconvolution) to recover superposed, transient evoked-responses

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