Branch retinal vein occlusion associated with quetiapine fumarate

Abstract

BackgroundTo report a case of branch retinal vein occlusion in a young adult with bipolar mood disorder treated with quetiapine fumarate.Case PresentationA 29 years old gentleman who was taking quetiapine fumarate for 3 years for bipolar mood disorder, presented with sudden vision loss. He was found to have a superior temporal branch retinal vein occlusion associated with hypercholesterolemia.ConclusionAtypical antipsychotic drugs have metabolic side effects which require regular monitoring and prompt treatment.

Branch Retinal Vein Occlusion

“…Over the recent years, there have been a number of anecdotal case reports of BRVO with many systemic diseases, including Bartonella [ 17 ], Behcet's disease [ 18 , 19 ], Coats' disease [ 20 ], Crohn's disease [ 21 ], deep-sea diving [ 22 ], Eales' disease [ 23 ], focal retinal phlebitis [ 24 ], high altitude [ 25 ], human immunodefi ciency virus [ 26 , 27 ], infl iximab treatment [ 28 ], interferon therapy [ 29 ], lipemia retinalis [ 30 ], during fi ngolimod treatment of multiple sclerosis [ 31 ], ocular candidiasis [ 32 ], ocular Lyme borreliosis [ 33 ], ocular tuberculosis [ 34 ], primary intraocular lymphoma [ 35 ], pseudoexfoliation [ 36 , 37 ], quetiapine fumarate [ 38 ], sarcoidosis [ 39 -42 ], superior ophthalmic vein thrombosis [ 43 ], systemic lupus erythematosus [ 44 ], Takayasu's arteritis [ 45 ], tamoxifen [ 46 ], toxoplasmic chorioretinitis [ 47 ], Tsutsugamushi disease [ 48 ], and Waardenburg syndrome [ 49 ]. As discussed above, the association of a condition with a systemic disease does not always mean cause and effect.…”

Getting the picture: visual interpretation in ophthalmology residency training

“…Fundus photograph depicting a branch retinal vein occlusion. Image adapted from Yong KC et al, desaturated from original. Used under Creative Commons Attribution 2.0 Generic License.…”

Quetiapine associated Central Serous Chorioretinopathy: Implicit role of serotonin and dopamine pathways

“…[4] Hyperlipidemia and thromboembolism that indirectly affect vascular perfusion have been considered as underlying factors in quetiapine-associated retinal venous occlusions; one of these cases had a concurrent pigment epithelial detachment, a frequent concomitant feature of CSCR. [56]…”

“…Ocular adverse effects include blurring of vision, retinal vein occlusion, oculogyric crisis, ocular pain, transient myopia, narrow angle, halos around lights, hallucinations as in Charles–Bonnet syndrome, and photopsiae. [456] A case of CSCR associated with quetiapine is presented. He had a marked regression on drug withdrawal and recurrence on inadvertent re-challenge.…”