Branching pattern of corticothalamic projections from the somatosensory cortex during postnatal development in the rat

Frassoni, Carolina; Arcelli, P.; Regondi, Maria Cristina; Selvaggio, M.; Bias, S. De; Spreafico, Roberto

doi:10.1016/0165-3806(96)83491-2

Cited by 17 publications

(15 citation statements)

References 23 publications

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“…Because neurons of the VB and POm nuclei undergo their final mitotic divisions over roughly the same period (McAllister and Das, 1977;Altman and Bayer, 1989), one possibility is that the two sets of axons reach the barrel cortex simultaneously. This could be consistent with the observation that small numbers of retrogradely labeled neurons are found in the POm nucleus at P1 after dye injection into S1 at P0 (Frassoni et al, 1995). It is known that VB afferents arrive at the cortex thalamotopically organized (Dawson and Killackey, 1985;Blakemore and Molnar, 1990;Catalano et al, 1996) and first form a nascent barrel-like organization in deep layers, before the emergence of layer IV from the cortical plate (Agmon et al, 1993;Schlaggar and O'Leary, 1994), which is precisely matched by nascent, barrel-like clusters of N-cadherin puncta at the layer V/VI border (Huntley and Benson, 1999).…”

Section: Differential Cadherin Localization May Reflect a Role In Comsupporting

confidence: 88%

Developmental patterns of cadherin expression and localization in relation to compartmentalized thalamocortical terminations in rat barrel cortex

Gil

Needleman

Huntley

2002

J of Comparative Neurology

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The wiring of synaptic circuitry during development is remarkably precise, but the molecular interactions that enable such precision remain largely to be defined. Cadherins are cell adhesion molecules hypothesized to play roles in axon growth and synaptic targeting during development. We previously showed that N-cadherin localizes to ventrobasal (VB) thalamocortical synapses in rat somatosensory (barrel) cortex during formation of the whisker-map in layer IV (Huntley and Benson [1999] J. Comp. Neurol. 407:453-471). Such specific association of N-cadherin with one identified afferent pathway raises the prediction that other cadherins are expressed in barrel cortex and that these are, in some combination, also differentially associated with distinct inputs. Here, we first show that N-cadherin and three other classic cadherins (cadherin-6, -8, and -10) are expressed contemporaneously in barrel cortex with relative levels of postnatal expression that are highest during the first 2 weeks, when afferent and intrinsic circuitries are forming and synaptogenesis is maximal. Each displayed distinct, but partly overlapping laminar patterns of expression that changed over time. Cadherin-8 probe hybridization formed a particularly striking pattern of intermittent, columnar patches extending from layer V through layer III, which was first detectable at approximately postnatal day 3. The patches were centered precisely over regions of dysgranular layer IV and, in the whisker barrel field, over barrel septa. This pattern is similar to that formed by the terminal distribution of thalamocortical afferents arising from the posterior nucleus (POm), suggesting cadherin-8 association with the POm thalamocortical synaptic circuit. Consistent with this, cadherin-8 mRNAs were enriched in the POm nucleus, and cadherin-8 immunolabeling in layer IV was enriched in barrel septa and codistributed with labeled POm thalamocortical synaptic-like puncta. The striking molecular parcellation of at least two different cadherins to the two, converging thalamic pathways that terminated in non-overlapping barrel center and septal compartments in layer IV strongly suggested that cadherins provide requisite molecular recognition and targeting that enable precise construction of thalamocortical and other synaptic circuitry.

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Section: Differential Cadherin Localization May Reflect a Role In Comsupporting

confidence: 88%

Developmental patterns of cadherin expression and localization in relation to compartmentalized thalamocortical terminations in rat barrel cortex

Gil

Needleman

Huntley

2002

J of Comparative Neurology

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“…6C), coinciding with active periods of axon branching and collateralization of cortico-striatal and cortico-thalamic axons (Frassoni et al, 1995; Nisenbaum et al, 1998; Sheth et al, 1998). This neuropil staining remains (albeit at lower intensity) through P14 and P16 (Fig.…”

Section: Resultsmentioning

confidence: 94%

Dynamic gene and protein expression patterns of the autism‐associated met receptor tyrosine kinase in the developing mouse forebrain

Judson

Bergman

Campbell

et al. 2009

J of Comparative Neurology

165

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The establishment of appropriate neural circuitry depends upon the coordination of multiple developmental events across space and time. These events include proliferation, migration, differentiation, and survival - all of which can be mediated by hepatocyte growth factor (HGF) signaling through the Met receptor tyrosine kinase. We previously found a functional promoter variant of the MET gene to be associated with autism spectrum disorder, suggesting that forebrain circuits governing social and emotional function may be especially vulnerable to developmental disruptions in HGF/Met signaling. However, little is known about the spatiotemporal distribution of Met expression in the forebrain during the development of such circuits. To advance our understanding of the neurodevelopmental influences of Met activation, we employed complementary Western blotting, in situ hybridization and immunohistochemistry to comprehensively map Met transcript and protein expression throughout perinatal and postnatal development of the mouse forebrain. Our studies reveal complex and dynamic spatiotemporal patterns of expression during this period. Spatially, Met transcript is localized primarily to specific populations of projection neurons within the neocortex and in structures of the limbic system, including the amygdala, hippocampus and septum. Met protein appears to be principally located in axon tracts. Temporally, peak expression of transcript and protein occurs during the second postnatal week. This period is characterized by extensive neurite outgrowth and synaptogenesis, supporting a role for the receptor in these processes. Collectively, these data suggest that Met signaling may be necessary for the appropriate wiring of forebrain circuits with particular relevance to social and emotional dimensions of behavior.

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“…The increasing association of mGluR1␣ with corticothalamic synapses is also relevant to the development of corticothalamic innervation of VP and helps to explain the results of parallel physiological studies. In the rat, during the first postnatal week (P1-P6), corticothalamic axons innervating VP have few branches, but from P6-P9, dense aborizations with clusters of terminals are formed (Frassoni et al, 1995). At a comparable time in the mouse, VP cells are showing dramatic in- Fig.…”

Section: Developmental Changes In Mglur Immunostaining Patternsmentioning

confidence: 96%

Changes in subcellular localization of metabotropic glutamate receptor subtypes during postnatal development of mouse thalamus

1998

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High resolution immunoelectron microscopy was used to study subcellular localization patterns of three metabotropic glutamate receptor subtypes (mGluR1alpha, mGluR5, and mGluR2/3) during postnatal development of mouse ventral posterior (VP) thalamic nucleus. Immunoreactivity for all three mGluRs was detected from birth (postnatal day 0, P0), but mGluR1alpha showed dramatic changes in localization with age. In the first postnatal week, mGluR1alpha immunoreactivity was mainly found in proximal dendrites and somata and not usually associated with synaptic contacts. From the second postnatal week, it became concentrated in distal dendrites and preferentially associated with corticothalamic (RS) synapses. mGluR5 immunoreactivity was weaker than mGluR1alpha immunoreactivity at all postnatal ages and showed a similar change in subcellular distribution to that of mGluR1alpha. It was also localized in astrocytic processes. mGluR2/3 immunoreactivity was mainly localized in astrocytic processes surrounding neuronal somata and synapses and this pattern was consistently maintained through all postnatal ages. A small number of presynaptic axon terminals were labeled for mGluR2/3 immunoreactivity and formed asymmetrical synapses. This study demonstrates that Group I mGluR proteins (mGluR1alpha and mGluR5) become redistributed in association with the development of corticothalamic function as demonstrated physiologically, whereas Group II mGluR proteins (mGluR2/3) are mainly associated with neuroglia.

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Branching pattern of corticothalamic projections from the somatosensory cortex during postnatal development in the rat

Cited by 17 publications

References 23 publications

Developmental patterns of cadherin expression and localization in relation to compartmentalized thalamocortical terminations in rat barrel cortex

Developmental patterns of cadherin expression and localization in relation to compartmentalized thalamocortical terminations in rat barrel cortex

Dynamic gene and protein expression patterns of the autism‐associated met receptor tyrosine kinase in the developing mouse forebrain

Changes in subcellular localization of metabotropic glutamate receptor subtypes during postnatal development of mouse thalamus

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