Brave new (strept)avidins in biotechnology

Laitinen, Olli H.; Nordlund, Henri R.; Hytönen, Vesa P.; Kulomaa, Markku S.

doi:10.1016/j.tibtech.2007.04.001

Cited by 177 publications

(144 citation statements)

References 36 publications

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“…Due to the performance of these compounds, the absorption of water and electrolytes from the large intestine decreases and the volume and pressure of the intestinal contents increase. This condition stimulates the movement of the large intestine and prevents obstruction and excretion [32,33].…”

Section: Constipation Treatmentmentioning

confidence: 99%

Investigation of Treatment Mechanisms of Psyco-Diegest Distilled on Digestive Diseases

Bakhshaei¹,

Ghafoori²

2017

J Appl Pharm

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There are a wide number of digestive system disorders, which impose a substantial influence on morbidity and mortality rates, worldwide. Ethno medicinal plant studies have become of particular interest and have become increasingly more valuable in the development of health care and conservation programs in different parts of the world. In developing countries, medicinal plants continue to be a main source of medication. It has been estimated that approximately 88% of the inhabitants of underdeveloped countries rely mainly on traditional medicine for their primary form of medicinal health care. This review investigates the available studies on the pharmacological effects of some medicinal plants (Aloysia triphlla, Citrus aurantium, Echium amoenum, Lavandula stoechas, Melissa officinalis, Valeriana officinalis, Viola odorata, Salix aegyptica and Cinnamomum zelanicum) on digestive diseases. The present article incorporated a detailed interpretation of the these nine medicinal plants, emphasizing its therapeutic uses, pharmacological properties and mechanism of action based on preclinical and clinical studies, safety issues along with the current research potential of the medicinal plants.

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Section: Constipation Treatmentmentioning

confidence: 99%

Investigation of Treatment Mechanisms of Psyco-Diegest Distilled on Digestive Diseases

Bakhshaei¹,

Ghafoori²

2017

J Appl Pharm

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“…Because of their ability to bind biotin very tightly, they are widely used in (strept)avidinbiotin binding technology that is a common tool in life sciences and nanotechnology. To further improve these protein tools and obtain genetically engineered (strept)avidins, protein engineering methods were applied including simple amino acid substitutions to change physico-chemical properties, or more complex changes, such as chimeric (strept)avidins, topology rearrangements and non-natural amino acid stitching into the active sites (Laitinen et al, 2007).…”

Section: Protein Engineering 36mentioning

confidence: 99%

Protein Engineering Methods and Applications

Turanlı-Yıldız¹,

Alkım²,

Petek³

2012

Protein Engineering

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“…Among these, the covalent nature bonding affinity has advantageous over noncovalent bonding in the ability to orient the immobilized molecule in a defined and precise fashion for forthcoming reactions. The affinity of biotin for streptavidin is one of the strongest and most stable known in biochemistry [27]. Moreover, a wide range of immobilizing materials and binding modes allows a great deal of flexibility in order to design a specific bond with specific physical and chemical properties such as charge distribution, hydrophobic/hydrophilic, etc.…”

Section: Solid-phase Versus Solution-phase Chemistry For Protein Syntmentioning

confidence: 99%