This study examines the multifaceted impacts of the U.S.-China trade war on global trade dynamics, with a particular focus on the role of BRICS. Initiated in 2018, the trade war marked a significant disruption in 21st-century global trade, leading to increased tariffs and strained economic relations between the world's two largest economies. The research explores how this conflict has reshaped global trade patterns, disrupted international supply chains, and influenced the strategies of multinational enterprises (MNEs). Additionally, it investigates the strategic responses of BRICS nations, highlighting their efforts to strengthen intra-group cooperation, reduce dependency on Western countries, and enhance their global influence. By analyzing mutual FDI flows, trade deficits, and GDP growth, this study provides a comprehensive understanding of the broader implications of the U.S.-China trade war, particularly in the context of BRICs and the evolving global economic order.