In this work, the Ti-6Al-4V alloy and ZrB 2 -SiC ultra-high temperature ceramic joint was brazed by TiCuZrNi amorphous filler at 910℃ with varied holding time. The element diffusion, microstructure and precipitation phase of the joints were analyzed in details. Reaction products in the joints were identified as β-Ti, (Ti,Zr) 2 (Cu,Ni), TiCu, Ti 2 Cu, TiC, Ti 5 Si 3 , TiB and TiB 2. The formation schemes of reaction products were investigated. The holding time has substantial impacts on interfacial microstructure and shear strength of joints. A maximum shear strength of 345 MPa of the joint was reached under a brazing temperature of 910℃ and holding time of 1200 s. It is also found that the shear strength depends on the amount of eutectic structure and brittle compounds in the joints.