BRCA 1 and 2 Mutations in Sudanese Secondary School Girls with Known Breast Cancer in Their Families

Elnour, Ahmed M.; Elderdery, Abozer Y.; Mills, Jeremy; Babiker, Mohammed; Abdelaal, Daw; Mohamed, A.; Elhassan, Kamal Eldin H.; Hady, Abdel; Wahab, Abdel; Cooper, Alan

doi:10.12816/0005974

Cited by 12 publications

(9 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Breast cancer is a major cause of morbidity and mortality in women worldwide. In this study, the highest percentage was registered for the breast cancer (24.8%), which was previously reported in several studies as a female leading cancer and as the most commonly diagnosed cancer in Sudan (Elnour, et al 2012). According to a statistical report from the Radiation and Isotopes center in Khartoum, approximately 836 women developed breast cancer in 2007 and 895 in 2008.…”

Section: Discussionsupporting

confidence: 74%

“…According to a statistical report from the Radiation and Isotopes center in Khartoum, approximately 836 women developed breast cancer in 2007 and 895 in 2008. This accounts for more than 30% of all cancers in women in Sudan and is estimated as 17.2% of all types of cancers in 2007 and 17.9% in 2008 (Elnour, et al 2012;Awadelkarim, et al 2007). In a survey of 2370 Sudanese students, 67 cases (47 with family history and 20 controls) were analyzed for BRCA1 and BRCA2 mutations with a single-stranded conformation polymorphism (SSCP) mutation detection method applied to peripheral blood.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Burden of Cancer in North Sudan: A community-based Survey

Ahmed

Eltom

Doumi

et al. 2014

Egyptian Academic Journal of Biological Sciences. C, Physiology

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Burden of Cancer in North Sudan: A community-based Survey

Ahmed

Eltom

Doumi

et al. 2014

Egyptian Academic Journal of Biological Sciences. C, Physiology

View full text Add to dashboard Cite

“…Genetically, breast cancer has autosomal dominant inheritance, predominantly for BRCA1/2 genes. Elnour et al [ 21 ] found that BRCA1/2 mutations to be common in Sudan. Awadelkarim et al [ 22 ] reached similar conclusions; moreover, they highlighted that 28% of their patients’ germline mutations to be novel.…”

Section: Discussionmentioning

confidence: 99%

Developing a risk prediction model for breast cancer: a Statistical Utility to Determine Affinity of Neoplasm (SUDAN-CA Breast)

et al. 2017

View full text Add to dashboard Cite

BackgroundBreast cancer risk prediction models are widely used in clinical settings. Although most of the well-known models were designed based on data collected from western population, yet they have been utilized for surveillance purposes in many limited-resource countries. Given the genetic variations in risk factors that exist between different races, we therefore aimed to develop and validate a tool for breast cancer risk assessment among Sudanese women.MethodsUsing cross-sectional design, 153 subjects were eligible to participate in our study. Data were collected from the only couple of tertiary centers in Sudan. They underwent multiple logistic regression using purposeful selection method to build the model. Various adjustments were made to determine significant predictors. Overall performance, calibration and discrimination were assessed by R 2, O/E ratio and c-statistic, respectively.ResultsSUDAN predictors of breast cancer were: age, menarche, family history, vegetables and fruits weekly servings, and type of cereals that traditional cuisine is made of. Both Nagelkerke R 2 (0.495) and O/E ratio (0.78) were good. c-statistic expressed the excellent discriminatory power of the model (0.864, p < 0.001, 95% CI 0.81–0.92).ConclusionsOur findings suggest that SUDAN provides a simple, efficient and well-calibrated tool to predict and classify women’s lifetime risks of developing breast cancer. Input from our model could be deployed to guide utilization of the more advanced screening modalities in resource-limited settings to maximize cost effectiveness. Consequently, this might improve the stage at which the diagnosis is usually made.

show abstract

“…About 51% of the students with a family history of breast cancer and 20% with no family history of breast cancer had BRCA1 and BRCA2 mutations. Most of the BRCA1 mutations located to exon 11 fragments 11.9 and 11.1 . Though, in a study that examined methylation status of six tumor suppressor genes that included BRCA1 , BRCA2 , p14 , p16 , hMLH, and MGMT in breast ( n = 23), other tumor ( n = 10), and control tissues ( n = 4) suggested that BRCA1 , BRCA2 , and p14 appeared to be under strong epigenetic silencing.…”

Section: Breast Cancermentioning

confidence: 99%

Part I: cancer in Sudan—burden, distribution, and trends breast, gynecological, and prostate cancers

et al. 2015

View full text Add to dashboard Cite

Despite the growing burden of cancer worldwide, it continues to receive low priority in Africa, across the continent and specifically in Sudan. This is due to political unrest, limited health resources, and other pressing public health issues such as infectious diseases. Lack of awareness about the magnitude of the current and future cancer burden among policy makers play a major role as well. Although, the real scope of cancer in Sudan is not known, the reported cases have increased from 303 in 1967–6303 in 2010. According to Globocan estimates, the top most common cancers in both sexes are breast, non-Hodgkin lymphoma, leukemia, esophagus, and colorectum. This review is the first of four papers that focuses on cancer, its distribution and trend as well as the risk factors most common in Sudan. It is expected that cancer will increase in Sudan as a result of migration of people from rural areas to urban cities in the pursuit of a better standard of living, which has resulted in lifestyle and behavioral changes that include tobacco chewing and smoking, unhealthy dieting, and a lack of physical activity. These changes are further exacerbated by the aging population and have made the country vulnerable to many diseases including cancer. These reviews are meant to provide a better understanding and knowledge required to plan appropriate cancer-control and prevention strategies in the country.

show abstract

BRCA 1 and 2 Mutations in Sudanese Secondary School Girls with Known Breast Cancer in Their Families

Cited by 12 publications

References 24 publications

Burden of Cancer in North Sudan: A community-based Survey

Burden of Cancer in North Sudan: A community-based Survey

Developing a risk prediction model for breast cancer: a Statistical Utility to Determine Affinity of Neoplasm (SUDAN-CA Breast)

Part I: cancer in Sudan—burden, distribution, and trends breast, gynecological, and prostate cancers

Contact Info

Product

Resources

About