BRD7 inhibits tumor progression by positively regulating the p53 pathway in hepatocellular carcinoma

Chen, Changlong; Mo, Huaqian; Jiang, Yanjun; Zhao, Xiaohui; Ma, Shuang; You, Kaiyun; Pan, Yue; Liu, Yimin

doi:10.7150/jca.50293

Cited by 9 publications

(3 citation statements)

References 38 publications

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“…Bromodomain-containing 7 (BRD7) subunit is present uniquely in the PBAF complex, which usually serves as a tumor-suppressor gene and is downregulated in multiple cancers, such as breast cancer, HCC, ovarian cancer, and colorectal carcinoma ( 186 , 202 , 203 ). Previous studies have demonstrated that BRD7 may inhibit tumorigenicity via multiple mechanisms, including Ras/MEK/ERK, β-catenin, p53, and BRCA1 pathways ( 204 ). For instance, a study by Chen et al.…”

Section: Other Swi/snf Members and Cancermentioning

confidence: 99%

“…For instance, a study by Chen et al. identifies that BRD7 inhibits cellular growth, motility, and cell cycling in HCC cells by positive regulation of p53 pathway activity ( 204 ). A variety of targets, such as estrogen receptor α (ERα), are regulated by BRD7 and BRCA1 coordinately in breast cancer, and BRD7 regulates ERα transcription by recruiting BRCA1 and Oct-1 to the promoter of ESR1 (the gene encoding ERα) ( 205 ).…”

Section: Other Swi/snf Members and Cancermentioning

confidence: 99%

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The Role of ARID1A in Tumors: Tumor Initiation or Tumor Suppression?

Tang

2021

Front. Oncol.

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Genes encoding subunits of SWItch/Sucrose Non-Fermenting (SWI/SNF) chromatin remodeling complexes are collectively mutated in 20% of all human cancers, among which the AT-rich interacting domain−containing protein 1A (ARID1A, also known as BAF250a, B120, C1orf4, Osa1) that encodes protein ARID1A is the most frequently mutated, and mutations in ARID1A have been found in various types of cancer. ARID1A is thought to play a significant role both in tumor initiation and in tumor suppression, which is highly dependent upon context. Recent molecular mechanistic research has revealed that ARID1A participates in tumor progression through its effects on control of cell cycle, modulation of cellular functions such as EMT, and regulation of various signaling pathways. In this review, we synthesize a mechanistic understanding of the role of ARID1A in human tumor initiation as well as in tumor suppression and further discuss the implications of these new discoveries for potential cancer intervention. We also highlight the mechanisms by which mutations affecting the subunits in SWI/SNF complexes promote cancer.

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Section: Other Swi/snf Members and Cancermentioning

confidence: 99%

Section: Other Swi/snf Members and Cancermentioning

confidence: 99%

The Role of ARID1A in Tumors: Tumor Initiation or Tumor Suppression?

Tang

2021

Front. Oncol.

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“…Our data demonstrate that dcPBAF does not contain Brd7 which is an important subunit of PBAF known as a tumor suppressor that inhibits growth and metastasis and initiates apoptosis in cancer cells ( Yu et al, 2016 ; Niu et al, 2020 ; Chen et al, 2021 ). BRD7 and PHF10 are PBAF-specific subunits that physically interact with each other, forming together with PBRM1 the histone tail interaction submodule of PBAF ( Yuan et al, 2022 ).…”

Section: Discussionmentioning

confidence: 73%

A novel chromatin-remodeling complex variant, dcPBAF, is involved in maintaining transcription in differentiated neurons

Soshnikova,

Azieva,

Klimenko

et al. 2023

Front. Cell Dev. Biol.

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The Polybromo-associated BAF (BRG1- or BRM-associated factors) (PBAF) chromatin-remodeling complex is essential for transcription in mammalian cells. In this study, we describe a novel variant of the PBAF complex from differentiated neuronal cells, called dcPBAF, that differs from the canonical PBAF existing in proliferating neuroblasts. We describe that in differentiated adult neurons, a specific subunit of PBAF, PHF10, is replaced by a PHF10 isoform that lacks N- and C-terminal domains (called PHF10D). In addition, dcPBAF does not contain the canonical BRD7 subunit. dcPBAF binds promoters of the actively transcribed neuron-specific and housekeeping genes in terminally differentiated neurons of adult mice. Furthermore, in differentiated human neuronal cells, PHF10D-containing dcPBAF maintains a high transcriptional level at several neuron-specific genes.

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Identification of BRD7 by whole-exome sequencing as a predictor for intermediate-stage hepatocellular carcinoma in patients undergoing TACE

Huang

Fan

et al. 2023

J Cancer Res Clin Oncol

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BRD7 inhibits tumor progression by positively regulating the p53 pathway in hepatocellular carcinoma

Cited by 9 publications

References 38 publications

The Role of ARID1A in Tumors: Tumor Initiation or Tumor Suppression?

The Role of ARID1A in Tumors: Tumor Initiation or Tumor Suppression?

A novel chromatin-remodeling complex variant, dcPBAF, is involved in maintaining transcription in differentiated neurons

Identification of BRD7 by whole-exome sequencing as a predictor for intermediate-stage hepatocellular carcinoma in patients undergoing TACE

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