Break-through COVID-19 infection rate with Indian strain in Single-center Healthcare Workers – A real world data

Sabnis, Ravindra; Patil, Abhijit; Shete, Nitiraj; Rastogi, Arun Kumar

doi:10.1101/2021.07.02.21258881

Cited by 9 publications

(10 citation statements)

References 9 publications

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“…Comparison with other studies is mentioned in Table 4. The mean age of patients with breakthrough infections was 35.07 (±10.38) years and most of the vaccinated individuals, as well as the, vaccinated infected individuals were females i.e, 79.83% and 75% respectively similar to the findings of Sabnis R et.al [17].…”

Section: Resultssupporting

confidence: 84%

“…The breakthrough infection rate among the vaccinated health care workers in the previous studies was found to be 18.65% and 13.3% [14,15] and it is 6.58 % in our study. Comparison with other studies is mentioned in Table 4.…”

Section: Resultssupporting

confidence: 52%

“…The mean age of patients with breakthrough infections was 35.07 (±10.38) years and most of the vaccinated individuals, as well as the, vaccinated infected individuals were females i.e, 79.83% and 75% respectively similar to the findings of Sabnis R et.al[17]. International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.…”

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confidence: 74%

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SARS-CoV-2 Breakthrough Infections among the Healthcare Workers Post-Vaccination with ChAdOx1 nCoV-19 Vaccine in the South Indian State of Kerala

Issac¹,

Kochuparambil²,

Elizabeth³

2021

Preprint

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Objective: The national COVID-19 vaccination campaigns in India, prioritized healthcare workers to be vaccinated with ChAdOx1 nCoV-19 (AZD1222). So, we aimed to ascertain the effectiveness of the ChAdOx1 nCoV-19 vaccine among the healthcare workers by characterizing the breakthrough infections which occurred 14 days after the second dose of the vaccine. Methods: We prospectively evaluated the Institutional Covid Vaccination Database to categorize the SARS-CoV-2 positive healthcare workers into 2 cohorts: infected vaccinated and infected unvaccinated cohort. Along with comparing the descriptive statistics of the cohorts, the relative risk (RR), relative risk reduction (RRR), and the vaccine effectiveness were calculated. The study population was compared for the significant difference by using the parametric model (binary logistic regression) for the Odds ratio and the non-parametric model (cox proportionality model) for the Hazard ratio. Results: Out of the 324 healthcare workers employed in our institution 243 (75%) were vaccinated. When 6.58% (16) of the vaccinated healthcare workers were tested positive, 43.75% (35) were infected in the unvaccinated cohort and the median time of infection in the vaccinated cohort was 65 days (range 20 - 91 days). While the cox proportionality model reveals that the age, sex, and the contact exposure status of the cohort are not significant factors for getting infected after being vaccinated, binary logistic regression proves that a significant relationship exists between the incidence of infection and the unvaccinated status (p = 0.001, OR = 4.278). Completing the two-dose of vaccination decreased the hazard of testing positive for the SARS-CoV-2 by 84.96 % when compared with the unvaccinated individuals, which is the effectiveness of the ChAdOx1 nCoV-19 vaccine. Conclusion: There is an increased risk of the third wave of COVID-19 infection in the upcoming months. So, primary infection control measures should be followed even if vaccinated, to prevent the risk of breakthrough infections.

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Section: Resultssupporting

confidence: 84%

Section: Resultssupporting

confidence: 52%

supporting

confidence: 74%

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SARS-CoV-2 Breakthrough Infections among the Healthcare Workers Post-Vaccination with ChAdOx1 nCoV-19 Vaccine in the South Indian State of Kerala

Issac¹,

Kochuparambil²,

Elizabeth³

2021

Preprint

View full text Add to dashboard Cite

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“…We finalized 18 studies from across the world[ 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 ] that fully filled all the inclusion criteria, with 2,30,000 healthcare workers as shown in the flow chart. All studies were of high quality based on the “New-Castle Ottawa Scoring System.” The ratio of the vaccinated and the non-vaccinated individuals was 16.4:1, whereas the ratio of the fully vaccinated to partially vaccinated individuals was 1.12:1.…”

Section: R Esultsmentioning

confidence: 99%

“…[ 5 6 7 8 9 10 ] The data available vary among different populations with reinfections. [ 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 ] Hence, we conducted a systematic review and meta-analysis of infections breakthrough after COVID vaccination among healthcare workers.…”

Section: Introductionmentioning

confidence: 99%

COVID Infections Breakthrough Post-Vaccination

Ali

Bhattacharyya

Ahmad

et al. 2022

Journal of Pharmacy and Bioallied Sciences

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Introduction: Many new variants of the coronavirus are infecting the already vaccinated people. There have been reports of deaths also among the already vaccinated subjects. Hence, we conducted a systematic review and meta-analysis of the infection breakthrough after COVID vaccination. Materials and Methods: We piloted a review of the healthcare workers who completed the vaccination for COVID. The data were collected from the online resources for the breakthrough infections after vaccination. We then enumerated those subjects who had a breakthrough infection post-vaccination. The data collected were meta-analyzed for the incidence of the infection among the vaccinated individuals. Results: We observed that among nearly 2.3 lakh subjects, less than 3% were infected with the various new strains of the virus. The ratio of the breakthrough infection was different for the vaccinated (1.2%) and the partially vaccinated (3.2%) individuals with greater infection among the partially infected individuals. Discussion: The breakthrough infections are very low among vaccinated individuals and even lower among fully vaccinated individuals. Hence, vaccination is highly recommended to prevent the loss of life.

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Postvaccination SARS‐CoV‐2 infection among healthcare workers: A systematic review and meta‐analysis

Chandan

Khan

Deliwala

et al. 2021

Journal of Medical Virology

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Healthcare workers (HCWs) remain on the front line of the battle against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease 2019 (COVID-19) infection and are among the highest groups at risk of infection during this raging pandemic. We conducted a systematic review and meta-analysis to assess the incidence of postvaccination SARS-CoV-2 infection among vaccinated HCWs. We searched multiple databases from inception through August 2021 to identify studies that reported on the incidence of postvaccination SARS-CoV-2 infection among HCWs. Meta-analysis was performed to determine pooled proportions of COVID-19 infection in partially/fully vaccinated as well as unvaccinated individuals. Eighteen studies with 228 873 HCWs were included in the final analysis. The total number of partially vaccinated, fully vaccinated, and unvaccinated HCWs were 132 922, 155 673, and 17 505, respectively. Overall pooled proportion of COVID-19 infections among partially/ fully vaccinated and unvaccinated HCWs was 2.1% (95% confidence interval [CI]1.2-3.5). Among partially vaccinated, fully vaccinated and unvaccinated HCWs, pooled proportion of COVID-19 infections was 2.3% (CI 1.2-4.4), 1.3% (95% CI 0.6-2.9), and 10.1% (95% CI 4.5-19.5), respectively. Our analysis shows the risk of COVID-19 infection in both partially and fully vaccinated HCWs remains exceedingly low when compared to unvaccinated individuals. There remains an urgent need for all frontline HCWs to be vaccinated against SARS-CoV-2 infection.

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Break-through COVID-19 infection rate with Indian strain in Single-center Healthcare Workers – A real world data

Cited by 9 publications

References 9 publications

SARS-CoV-2 Breakthrough Infections among the Healthcare Workers Post-Vaccination with ChAdOx1 nCoV-19 Vaccine in the South Indian State of Kerala

SARS-CoV-2 Breakthrough Infections among the Healthcare Workers Post-Vaccination with ChAdOx1 nCoV-19 Vaccine in the South Indian State of Kerala

COVID Infections Breakthrough Post-Vaccination

Postvaccination SARS‐CoV‐2 infection among healthcare workers: A systematic review and meta‐analysis

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