Breakdown of adenosine triphosphate during a single contraction of working muscle

Cain, D.F.; Davies, R. E.

doi:10.1016/0006-291x(62)90008-6

Cited by 225 publications

(69 citation statements)

References 5 publications

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“…However, in order better to observe the thermodynamic capabilities of mitochondria, it was desirable to measure the thermodynamic potential during actual muscle function in terms of the phosphocreatine-phosphate ratio. While biochemical analysis served well, and Cain and Davies (3) and Kushmerick and Davies (21) were able to observe for the first time the direct function of ATP as the energy donor in muscle contraction and the association of ATP splitting and external work by blocking phosphocreatine resynthesis by fluoro-dinitrobenzene, real-time measurements of phosphocreatine depletion in human muscle was possible only by serial biopsy.…”

Section: Pnmr Spectroscopymentioning

confidence: 99%

“…PCr is a readily available equivalent energy source to ATP owing to high creatine kinase activity in the skeletal muscle [Lohmann reaction, Cain et al (1962), eqn (1)] (47). The turnover number of CK is tenfold higher (30 mm/s/g) than ATP utilization and oxidative ATP synthesis (less than 3 mm/s/g), measured by the PNMR saturation transfer technique in heart (48) and skeletal muscle (49).…”

Section: Pcr As An Energy Sourcementioning

confidence: 99%

“…It is important to note the development of ideas on respiration and muscle energetics, which proceeded on antiparallel lines since it was not clear that ATP was the energy source for muscle contraction until the works of Davies (3,4) and Kushmerick (5) were published.…”

Section: Introductionmentioning

confidence: 99%

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Skeletal muscle energetics with PNMR: personal views and historic perspectives

Chance

Nioka

et al. 2006

NMR in Biomedicine

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This article reviews historical and current NMR approaches to describing in vivo bioenergetics of skeletal muscles in normal and diseased populations. It draws upon the first author's more than 70 years of personal experience in enzyme kinetics and the last author's physiological approaches. The development of in vivo PNMR jointly with researchers around the world is described. It is explained how non-invasive PNMR has advanced human exercise biochemistry, physiology and pathology. Further, after a brief explanation of bioenergetics with PNMR on creatine kinase, anerobic glycolysis and mitochondrial oxidative phosphorylation, some basic and controversial subjects are focused upon, and the authors' view of the subjects are offered, with questions and answers. Some of the research has been introduced in exercise physiology. Future directions of NMR on bioenergetics, as a part of system biological approaches, are indicated.

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Section: Pnmr Spectroscopymentioning

confidence: 99%

Section: Pcr As An Energy Sourcementioning

confidence: 99%

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Skeletal muscle energetics with PNMR: personal views and historic perspectives

Chance

Nioka

et al. 2006

NMR in Biomedicine

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“…The break-down of ATP is thought to provide the immediate source of energy for muscle contraction (Cain & Davies, 1962) but Bergstr6m found that the concentration of ATP did not change appreciably in contracting muscle, probably because it was rapidly resynthesized from creatine phosphate.…”

Section: Release Of P04 From Active Human Muscle 417mentioning

confidence: 99%

Experiments on the liberation of phosphate from the muscles of the human forearm during vigorous exercise and on the action of sodium phosphate on forearm muscle blood vessels

Barcroft¹,

Foley²,

McSwiney³

1971

The Journal of Physiology

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“…It is used to feed the contraction process when combined with phosphate, being converted into phosphocreatine, which is essential for producing quick short energy bursts (Cain & Davies, 1962).The initial fuel used for muscle contraction is ATP, which supplies energy by releasing one of its phosphate molecules, and being converted into adenosine diphosphate (ADP) (Febbraio et al, 1995). However, this system supplies energy for only a few seconds, after which new ATP molecules need to be produced.…”

Section: Introductionmentioning

confidence: 99%

Effects of Guanidionoacetic Acid and Arginine Supplementation to Vegetable Diets Fed to Broiler Chickens Subjected to Heat Stress before Slaughter

Esser

Gonçalves

Rorig

et al. 2017

Rev. Bras. Cienc. Avic.

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The objective of this study was to evaluate the supplementation of guanidinoacetic acid (GAA) and L-arginine (L-Arg) as creatine precursors to vegetable diets on the carcass yield and meat quality of broilers subjected to two days of heat stress before slaughter. A total of 1260 broiler chicks were distributed according to a completely randomized design into four treatments with nine replicates of 35 birds each. The treatments consisted of: T1 -vegetable diet based on corn and soybean meal (control diet); T2 -control diet with the inclusion of meat meal (3%); T3 -control diet supplemented with GAA (0.08%); and T4 -control diet supplemented with L-Arg (0.8%). The birds were submitted to heat stress for two days before slaughter (from 42 to 44 days of age). The birds fed the diets supplemented with GAA or L-Arg presented heavier carcasses (p<0.0035), higher breast yield (p=0.0685), and lower of abdominal fat deposition (p=0.0508) than those fed the control diet and the control diet with meat meal. The cooking loss of the breast fillets of broilers fed the control diet supplemented with meat meal, GAA or L-Arg was lower (p<0.0068) compared with those fed the control diet. Thawing and pressure-driven breast fillet weight losses, and pH, luminosity, redness (a*value), and yellowness (b* value) values were not influenced by the treatments. When GAA is less expensive than commercially-available Arg, the dietary supplementation of GAA is more advantageous, based on the meat yield improvements observed in the present study.

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Breakdown of adenosine triphosphate during a single contraction of working muscle

Cited by 225 publications

References 5 publications

Skeletal muscle energetics with PNMR: personal views and historic perspectives

Skeletal muscle energetics with PNMR: personal views and historic perspectives

Experiments on the liberation of phosphate from the muscles of the human forearm during vigorous exercise and on the action of sodium phosphate on forearm muscle blood vessels

Effects of Guanidionoacetic Acid and Arginine Supplementation to Vegetable Diets Fed to Broiler Chickens Subjected to Heat Stress before Slaughter

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