Breaking through restricting bottleneck for better asthma control

Zhu, Dingliang; Zhang, Chao; Shen, Huahao; Ying, Songmin

doi:10.1515/jtim-2017-0032

Cited by 4 publications

(4 citation statements)

References 22 publications

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“…Asthma management for reducing inflammation of the air passage is through minimising pre-inflammatory environmental contacts using daily anti-inflammatory drugs and controlling the condition of the onset of the condition that makes asthma worse [ 2 ]. Less inflammation usually leads to better control of asthma, with fewer attacks, and reduction of the need for fast-paced asthma medications, but the attacks keep happening yet [ 3 ]. Early intervention with systemic corticosteroids greatly reduces the severity of such attacks [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Quality of Life in Children with Asthma versus Healthy Children

Kouzegaran¹,

Samimi²,

Ahanchian³

et al. 2018

Open Access Maced J Med Sci

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BACKGROUND:Asthma is the most prevalent chronic disease in the pediatric age group. The disease affects different aspects of the children’s lives, such as physical, emotional, social and educational aspects. Thus, more focus has been on the quality of life in these patients rather than the duration of their illness in recent years.AIM:This study examined the different aspects of quality of life in asthmatic children for the first time in this geographic area.METHODS:The study was cross-sectional conducted in 2015-2016. The asthmatic group was 100 patients aged 8 to 12 admitted to the Asthma and Allergy Clinic of Ghaem Hospital (as) in Mashhad with the control group composed of 100 healthy children of the same age and gender. The standard questionnaire pedsQLTM was used for comparing the quality of life of children in the two groups. Statistical analysis was SPSS23 with P-value less than 0.05, which was statistically significant.RESULTS:In each group, 58 patients were boys, and 42 were girls. In a comparison of the quality of life of children, the asthma group with a mean total score of Peds QL 20.99 ± 12.54 compared to the healthy children with a mean total score of Peds QL of 8.8 ± 5.41 had a lower quality of life (P < 0.001). Moreover, regarding various aspects of quality of life asthma group had a lower quality of life in physical performance, emotional performance and performance in school (P < 0.001). Nonetheless, there was no significant difference between the two groups considering social function (P = 0.267). Examining the relationship between Peds QL score of patients with asthma with various variables was indicative of the fact that Peds QL scores were significantly correlated with the gender of the patients, showing better quality of life in the girls (P = 0.001).CONCLUSION:The results indicated that children with asthma have a significantly lower quality of life compared with healthy children of the same age. Also, in examining the different aspects of quality of life, these children had a lower quality of life in physical performance, emotional performance, and performance at school, and were at the level as that of healthy children only in social performance.

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Section: Introductionmentioning

confidence: 99%

Quality of Life in Children with Asthma versus Healthy Children

Kouzegaran¹,

Samimi²,

Ahanchian³

et al. 2018

Open Access Maced J Med Sci

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“…The International Health Organization (WHO) estimated that 339 million people worldwide suffer from asthma. Asthma is one of the most frequent pediatric disorders among American children, ranging from 16% in Greece to 30% throughout European [2,3]. According to a recent study, the total prevalence of asthma in American children under the age of 15 was 13.9% (95% CI 9.6-18.3) [4].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Asthma on the Quality of Life in Children

Hussein,

Odhaib Altaher

2023

JHTD

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Background: Asthma is one of the most prevalent respiratory disorders, causing considerable morbidity and death among people of all ages. Objective: This paper aims to study and analyze the effect of asthma on the quality of life in children. Patients and methods: This paper studied and analyzed the effect of asthma on the quality of life in children with ages under 13 years were divided into two groups to patients and controls. The data collected were got on patients with 65 cases from 18th March 2021 to 24th July 2022 in different hospitals in Iraq. The collected data were estimated and designed by the SPSS program. Discussion: Our study noted that chest tightness, coughing, and difficulty breathing affect the difficulty of recovering from asthma patients, which increases the risk of developing asthma. With regard to complications, our study found that most of the complications were found to be difficult to control in asthmatic patients of the pediatric patients' group compared to the control group. Conclusion: In conclusion, the current results show that 70% of children with high obesity may be more susceptible to asthma than those with less obesity, than they may be at constant risk during childhood and adolescence. In addition, this study found comorbidities such as allergic rhinitis, atopic dermatitis, and obesity, as well as inappropriate and successful inhalation techniques for multivariate predictors of asthma performed in patients with high obesity over the control group, which had less obesity.

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“…Clinical studies show that the number of asthma patients around the world is as high as 300 million, and the prevalence of the disease varies from 1 to 18% across different countries (4,5). In China, the number of asthma patients is more than 30 million, and the mortality caused by asthma is the highest in the world (6,7). Of note, childhood asthma attracts more and more concern in medical practice, because this disease affects children and is easy to cause death (8).…”

Section: Introductionmentioning

confidence: 99%

Elevated expression of microRNA‑378 in children with asthma aggravates airway remodeling by promoting the proliferation and apoptosis resistance of airway smooth muscle cells

Lang

Xia

2018

Exp Ther Med

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The present study determined the expression of microRNA (miR)-378 in the peripheral blood and lung tissues of children with asthma, and investigated its effect and mechanism of action on the biological functions of airway smooth muscle cells. A total of 23 asthmatic children and 15 healthy children were included in the study. Peripheral blood and tissues were obtained from asthmatic children. Healthy children provided peripheral blood. Quantitative real-time polymerase chain reaction was used to determine the expression of miR-378. Airway smooth muscle cells were isolated and cultured in vitro. The cells were transfected with miR-378 mimics or miR-378 inhibitor. Following transfection, proliferation of the cells was determined using the CCK-8 assay. In addition, flow cytometry was used to detect the cell cycles and apoptosis of smooth muscle cells. Western blotting was performed to determine the expression of extracellular matrix proteins in smooth muscle cells. Furthermore, bioinformatics was used to predict potential target genes of miR-378 and their downstream signaling pathways. Results indicated that the expression of miR-378 in peripheral blood and lung tissues from asthmatic children was increased compared with that in healthy children. Serum from asthmatic children promoted the proliferation of smooth muscle cells in vitro by affecting the cell cycle, and enhanced apoptotic resistance of smooth muscle cells. Notably, overexpression of miR-378 increased the proliferation of smooth muscle cells by affecting the cell cycle, and this upregulated apoptotic resistance of smooth muscle cells and enhanced the expression of extracellular matrix-related proteins in smooth muscle cells. However, downregulation of miR-378 expression reversed the promoting effect of serum from asthmatic children on the biological functions of smooth muscle cells. These findings suggested that miR-378 possibly affects the proliferation, apoptosis and motility of airway smooth muscle cells via downstream signaling pathways. To conclude, the present study demonstrated that miR-378 expression was elevated in the peripheral blood and lung tissues from children with asthma. Furthermore, miR-378 promoted the biological functions of extracellular matrix-related proteins of smooth muscle cells, and possibly exerts its effect via its target genes through downstream signaling pathways.

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Breaking through restricting bottleneck for better asthma control

Cited by 4 publications

References 22 publications

Quality of Life in Children with Asthma versus Healthy Children

Quality of Life in Children with Asthma versus Healthy Children

The Effect of Asthma on the Quality of Life in Children

Elevated expression of microRNA‑378 in children with asthma aggravates airway remodeling by promoting the proliferation and apoptosis resistance of airway smooth muscle cells

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