Breast arterial calcification on screening mammography can predict clinically significant coronary artery disease (CAD) in the BreastCheck screening cohort.

Kelly, Brendan; Scanlan, Emer; McNally, Sorcha; Prichard, Ruth; Dodd, Jonathan D.

doi:10.1016/j.ejso.2017.01.023

Cited by 3 publications

(5 citation statements)

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“…A recent study showed that serum CRP evaluation was useful for patients at intermediate risk of CAD compared with other markers since CRP could predict the risk of CAD in first cardiovascular events from 10% to nearly 20% within a period of 10 years (Lubrano & Balzan, 2015;Shi et al, 2010). Similarly, there is growing evidence that elevation of serum hs-CRP levels predicts a poor cardiovascular prognosis and clinical outcomes in ACS and may be used to identify high-risk patients for more aggressive management with statins and antiplatelet agents (Kelly et al, 2017;Nakou et al, 2008). Furthermore, higher serum hs-CRP concentrations were positively correlated with peripheral arterial disease independent of body mass index (BMI), waist circumference, smoking, serum total cholesterol, blood pressure, and other confounders (Christiansen, 2017;Syvänen, Korhonen, Jaatinen, Vahlberg, & Aarnio, 2011).…”

Section: Coronary Artery Diseasesmentioning

confidence: 99%

“…Cardiovascular disease (CVD) comprises coronary artery disease (CAD), stroke, congestive heart failure, carotid artery disease, and peripheral artery disease (Nikpay et al, ). This disease is a common manifestation of atherosclerosis, which has now been established as a chronic inflammatory disorder (Kelly, Scanlan, McNally, Prichard, & Dodd, ; Nakou, Liberopoulos, Milionis, & Elisaf, ). CVD and the acute coronary syndrome (ACS) may be associated with complete or partial arterial thrombosis and atherosclerotic plaque rupture (Christiansen, ; Xu et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…CVD and the acute coronary syndrome (ACS) may be associated with complete or partial arterial thrombosis and atherosclerotic plaque rupture (Christiansen, ; Xu et al, ). CVD is the major cause of death, disability, and financial burden in most developed countries (Chandrashekara, ; Kelly et al, ).…”

Section: Introductionmentioning

confidence: 99%

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Serum C‐reactive protein in the prediction of cardiovascular diseases: Overview of the latest clinical studies and public health practice

Rezayi

Sany

Rahimi

et al. 2018

Journal Cellular Physiology

152

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Cardiovascular disease is the most common cause of morbidity and mortality globally. Epidemiological studies using high-sensitivity assays for serum C-reactive protein have shown a consistent association between cardiovascular disease risk and serum C-reactive protein concentrations. C-reactive protein is a biomarker for inflammation, and has been established in clinical practice as an independent risk factor for cardiovascular disease events. There is evidence that serum C-reactive protein is an excellent biomarker of cardiovascular disease and is also an independent and strong predictor of adverse cardiovascular events. Further characterization of the impact and influence of lifestyle exposures and genetic variation on the C-reactive protein response to cardiovascular disease events may have implications for the therapeutic approaches to reduce cardiovascular disease events. This review summarizes the studies that have examined the association between serum C-reactive protein and the risk of cardiovascular disease. We also discuss the impact of independent factors and C-reactive protein genetic polymorphisms on baseline plasma C-reactive protein levels.

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Section: Coronary Artery Diseasesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serum C‐reactive protein in the prediction of cardiovascular diseases: Overview of the latest clinical studies and public health practice

Rezayi

Sany

Rahimi

et al. 2018

Journal Cellular Physiology

152

View full text Add to dashboard Cite

show abstract

“…Table 2 summarizes current evidence of the association between BAC and coronary atherosclerosis. 3) 8) 9) 10) 11) 12) 13) 14) 15) 16) 17) 18) 19) 20) 21) 22) 23) 24) 25) Initially, several studies examined the relationship of BAC with coronary atherosclerosis based on a coronary angiography diagnosis. The results were inconsistent across the studies and a 5-study meta-analysis by Abi Rafeh et al 26) , including nearly 1000 women, demonstrated that patients with BAC had a 1.59-fold increased risk of CAD by angiography.…”

Section: Association Of Bac and Coronary Atherosclerosismentioning

confidence: 99%

Breast Arterial Calcification: A Potential Surrogate Marker for Cardiovascular Disease

Suh

Yun

2018

J Cardiovasc Imaging

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Breast arterial calcifications (BAC), frequently observed on screening mammography, have been considered as an incidental finding without increased risk for breast cancer. They are medial calcifications and therefore, are indicative of arteriosclerosis. Previous studies indicated that the risk factors of BAC partly overlap with those of cardiovascular disease (CVD), and the presence of BAC is associated with prevalent and incident CVD. This suggests that medial arterial calcification might contribute to CVD through a pathway distinct from the intimal atherosclerotic process. A recent study showed that the presence and severity of BAC are associated with the presence of coronary artery calcification or plaques on coronary computed tomography angiography in asymptomatic women aged more than 40 years. In addition, BAC provided an independent and incremental predictive value over conventional risk factors. Given that population-based mammography screening is currently recommended in asymptomatic women, the evaluation of BAC may be helpful in identifying high-risk women without additional cost or radiation exposure.

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“…These data substantiate the concept that serum hs-CRP reflects both atherosclerotic progression and CAD development among patients with CAD (Avan et al, 2018;Zheng et al, 2010) Previous studies displayed an elevated of hs-CRP secretion was acceptable for patients at intermediate risk of CAD compared with other biomarkers, since CRP is strong independent predictor of CAD risk in first cardiovascular events from 10% to nearly 20% (Lubrano & Balzan, 2015;Shi et al, 2010). It is also of interest that the elevation level of hs-CRP predicts clinical outcomes in acute coronary syndromes and used to identify high-risk patients for more aggressive management with antiplatelet agents and statins (Kelly, Scanlan, McNally, Prichard, & Dodd, 2017;Nakou, Liberopoulos, Milionis, & Elisaf, 2008).…”

Section: C-reactive Protein and Severity Of Cadmentioning

confidence: 99%

Relationship between serum high sensitivity C‐reactive protein with angiographic severity of coronary artery disease and traditional cardiovascular risk factors

Tajfard

Sany

Rezayi

et al. 2018

Journal Cellular Physiology

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Serum high‐sensitivity C‐reactive protein (hs‐CRP) is predictive of coronary artery disease (CAD). The aim of this study was to examine the possible association of hs‐CRP with presence and severity of CAD and traditional CAD risk factors. This case‐control study was carried out on 2,346 individuals from September 2011 to May 2013. Of these 1,187 had evidence of coronary disease, and were subject to coronary angiography, and the remainder were healthy controls (n = 1,159). Characteristics were determined using standard laboratory techniques and serum Hs‐CRP levels were estimated using enzyme‐linked immunosorbent assay (ELISA) kits, and severity of CAD was assessed according to the score of obstruction in coronary artery. Serum hs‐CRP levels were higher in those with severe coronary disease, who had stenosis ≥ 50% stenosis of at least one coronary artery (all p < 0.001 vs. individuals in healthy control), and correlated significantly with the score for coronary artery disease (all p < 0.01). After adjustment for conventional risk factors, regression analysis revealed that smoking habits, fasting blood glucose, total cholesterol, high‐density lipoprotein, hs‐CRP, blood pressure, anxiety, dietary intake of vitamin E, and cholesterol remained as independent determinants for angiographic severity of CAD. The area under the receiving operating characteristic (ROC) curve for serum hs‐CRP was 0.869 (CI 95% 0.721–0.872, p < 0.001). The optimal values for the cut‐off point was a serum hs‐CRP of 2.78 mg/l (sensitivity 80.20%, specificity 85%) to predict severity of CAD. Increased serum hs‐CRP levels are significantly associated with angiographic severity of CAD, suggesting its value as a biomarkers for predicting CAD.

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Breast arterial calcification on screening mammography can predict clinically significant coronary artery disease (CAD) in the BreastCheck screening cohort.

Cited by 3 publications

References 0 publications

Serum C‐reactive protein in the prediction of cardiovascular diseases: Overview of the latest clinical studies and public health practice

Serum C‐reactive protein in the prediction of cardiovascular diseases: Overview of the latest clinical studies and public health practice

Breast Arterial Calcification: A Potential Surrogate Marker for Cardiovascular Disease

Relationship between serum high sensitivity C‐reactive protein with angiographic severity of coronary artery disease and traditional cardiovascular risk factors

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