Breast Cancer Diagnosis in Women ≤ 40 versus 50 to 60 Years: Increasing Size and Stage Disparity Compared With Older Women Over Time

Zabicki, Katherina; Colbert, James A.; Domı́nguez, Francisco; Gadd, Michele A.; Hughes, Kevin S.; Jones, Julie L.; Specht, Michelle C.; Michaelson, James; Smith, Barbara L.

doi:10.1245/aso.2006.03.055

Cited by 84 publications

(62 citation statements)

References 30 publications

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“…The lack of decrease in stage despite detecting smaller tumors in the second period in our study can be related to the high rate of young breast cancer patients and higher rates of lymph node metastases in these patients. Indeed, the axillary lymph node metastasis rate in our series is higher than the National Breast Cancer Database (50%) as well as Western countries (30-40%), and shows a significant decrease in the second period of the study (6,7,13). The rates of lymph node metastasis in young patients during both study periods appear to be significantly higher as compared to patients over 40 years of age.…”

Section: Discussioncontrasting

confidence: 53%

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What has changed in clinical presentation of breast carcinoma over 15 years

Kınaş

Gülben

et al. 2015

UCD

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Section: Discussioncontrasting

confidence: 53%

“…Early diagnosis enables higher rates of surgical treatment, especially breast conserving surgery, thus yielding more successful treatment outcomes (5,6).…”

Section: Introductionmentioning

confidence: 99%

What has changed in clinical presentation of breast carcinoma over 15 years

Kınaş

Gülben

et al. 2015

UCD

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“…Despite the relative infrequency of the disease in young women, breast cancer is the leading cause of cancer-related death in women aged Յ40 years, and survival rates for young women with breast cancer are lower than those of their older counterparts [4]. Research has repeatedly revealed that younger women are more likely to present with larger sized tumors and a greater number of involved lymph nodes [5,6]. Factors that could contribute to these women pre- …”

Section: Introductionmentioning

confidence: 99%

The effect of age on delay in diagnosis and stage of breast cancer.

Partridge¹,

Hughes²,

Wong³

et al. 2010

JCO

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Background. Young women with breast cancer are more likely to present with more advanced disease and are more likely to die as a result of breast cancer than their older counterparts. We sought to examine the relationship among young age (<40 years), the likelihood of a delay in diagnosis, and stage.Methods. We examined data from women with newly diagnosed stage I-IV breast cancer presenting to one of eight National Comprehensive Cancer Network centers in January 2000 to December 2007. Delay in diagnosis was defined as time from initial sign or symptom to breast cancer diagnosis >60 days.Results. Among 21,818 women with breast cancer eligible for analysis, 2,445 were aged <40 years at diagnosis. Young

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“…In young women, the current data suggest a greatly reduced breast cancer risk associated with physical activity 36 . The mean age of patients was 36.29 years (23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40).It is less that than found in 37,38,27 . However, A. KWONG et al and JL.…”

Section: Resultsmentioning

confidence: 96%

Breast Carcinoma in Younger Algerian Eastern Women: Epidemiological Profile in Series of 135 Cases

Henouda¹

2015

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Abstract:Background: Actually, Breast cancer constitutes one of the most health problems in Algeria, and the leading cause of death among Algerian women. Breast cancer in young women is a rare form, but it has an aggressive behavior associated with a poor prognosis. Aims: this study focuses to report breast cancers phenotype in Algerian younger women. Material and methods: In order to better understand the determinants and tumor biology may explain earlier onset and aggressive breast cancers characteristics in Algeria from December 2011 to July 2014, 135 patients aged 40 years and under diagnosed with breast cancer were included in the study. Results: One hundred thirty-five women recorded, 65.9% patients were aged between 36-40 years. The mean age was 36.29 years. A significantly higher proportion of women were overweight or obese (62.9%). 75.6% patientshad full-term pregnancy. 29.6% breast cancers were diagnosed during pregnancy or after childbirth. 34.1% patients had a family history. In 87.4% of cases the revealing sign was nodule self-examination. Stage II and III associated with nodal extension, higher pathological grade, HR positive, were predominant. Neo-adjuvant was administered to 17.8%. 74.1%patients underwent radical mastectomy using Patey technique with complete axillary dissection.40.7% patients had distal metastases after diagnosis. The mean clinical tumor size was 4.88 cm.71.1% of tumors were invasive ductal carcinoma.69.9% patients had no family history. Conclusion: Breast tumors among Algerian young women are advanced with poor prognosis.

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Breast Cancer Diagnosis in Women ≤ 40 versus 50 to 60 Years: Increasing Size and Stage Disparity Compared With Older Women Over Time

Cited by 84 publications

References 30 publications

What has changed in clinical presentation of breast carcinoma over 15 years

What has changed in clinical presentation of breast carcinoma over 15 years

The effect of age on delay in diagnosis and stage of breast cancer.

Breast Carcinoma in Younger Algerian Eastern Women: Epidemiological Profile in Series of 135 Cases

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