Breast Cancer in a Tree Shrew (Tupaia glis)

Elliot, Orville; Elliot, Marjorie W.; Lisco, Hermann

doi:10.1038/2111105a0

Cited by 28 publications

(19 citation statements)

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“…The intraductal papilloma may progress to papillary carcinoma when mammary gland epidermis infiltrate into the stroma, with or without invasion (Pal et al, 2010). The breast tumor reported by Elliot et al (1966) was adenocarcinoma, which is an epithelium cancer that originates in glandular tissue.…”

Section: Discussionmentioning

confidence: 99%

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Characterization of spontaneous breast tumor in tree shrews (<I>Tupaia belangeri chinenesis</I>)

Xia¹,

Wang²,

Zhang³

et al. 2013

Zoological Research

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Breast cancer is a common malignant tumor. It is essential to develop suitable animal models for discovering novel preventive and therapeutic approaches. Tree shrews (Tupaia belangeri chinensis) have a closer evolutionary relationship with humans than do rodents, which have been widely used in laboratory research. Spontaneous breast tumors were identified in tree shrews in 1960s; however, no detailed studies about tree shrew breast tumors have been conducted to date. Here, we characterized a spontaneous breast tumor from tree shrews by Haematoxylin Eosin (H&E) staining. This tumor was identified as a papillary tumor. Immunohistochemical staining (IHC) for progesterone receptor (PR), Ki-67 and cleaved caspase-3 showed that tumor cells were positive for PR, highly proliferative, and less apoptotic compared to normal breast epithelial cells. Thus, the spontaneous tumor of tree shrew is very close to human papillary tumors in terms of morphology and pathology and we concluded that tree shrew may be a suitable animal model for breast cancer research.

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Section: Discussionmentioning

confidence: 99%

“…In 1966, the first spontaneous breast cancer was observed in tree shrews (Elliot et al, 1966). After that, several different types of spontaneous cancers such as hepatocellular carcinoma (Hofmann et al, 1981), epidermoid carcinoma (Darai et a1, 1982), Leydig cell tumor (Brack, 1988), and pulmonary tumor (Brack et al, 1996) have been reported.…”

mentioning

confidence: 99%

Characterization of spontaneous breast tumor in tree shrews (<I>Tupaia belangeri chinenesis</I>)

Xia¹,

Wang²,

Zhang³

et al. 2013

Zoological Research

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“…The histology of tree shrew mammary glands is also similar to rodents and primates. 4 The first spontaneous tree shrew breast cancer was reported in 1966, 5 and several of our studies have characterized a large number of spontaneous tree shrew breast cancers. 4,6 Furthermore, we demonstrated that 7,12-dimethylbenz(a)anthracene (DMBA) plus medroxyprogesterone acetate (MPA) successfully induced tree shrew breast cancer.…”

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confidence: 99%

Generation and characterization of a breast carcinoma model by PyMT overexpression in mammary epithelial cells of tree shrew, an animal close to primates in evolution

Xia

et al. 2015

Intl Journal of Cancer

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The tree shrew is becoming an attractive experimental animal model for human breast cancer owing to a closer relationship to primates/humans than rodents. Tree shrews are superior to classical primates because tree shrew are easier to manipulate, maintain and propagate. It is required to establish a high-efficiency tree shrew breast cancer model for etiological research and drug assessment. Our previous studies suggest that 7,12-dimethylbenz(a)anthracene (DMBA) and medroxyprogesterone acetate (MPA) induce breast tumors in tree shrews with a low frequency (<50%) and long latency (~7-month), making these methods less than ideal. We induced mammary tumors in tree shrew (Tupaia belangeri chinensis) by injection of lentivirus expressing the PyMT oncogene into mammary ducts of 22 animals. Most tree shrews developed mammary tumors with a latency of about three weeks, and by 7 weeks all injected tree shrews had developed mammary tumors. Among these, papillary carcinoma is the predominant tumor type. One case showed lymph node and lung metastasis. Interestingly, the expression levels of phosphorylated AKT, ERK and STAT3 were elevated in 41-68% of PyMT-induced mammary tumors, but not all tumors. Finally, we observed that the growth of PyMT-induced tree shrew mammary tumors was significantly inhibited by Cisplatin and Epidoxorubicin. PyMT-induced tree shrew mammary tumor model may be suitable for further breast cancer research and drug development, due to its high efficiency and short latency.Breast cancer remains the most common disease in women worldwide, with some 1.7 million new cases and 500,000 deaths reported each year, the bulk of both being in developing countries.1 While total survival rates averaged across all types of breast cancer can be as high as 80% in some developed countries, in less developed areas these rates drop to <40%, primarily due to a lack of comprehensive early diagnostics paired with a dearth of cost-effective treatments. 2These lop-sided statistics-wherein the areas with the most cases have the worst outcomes and least access to treatments-highlight the importance of ongoing efforts to refine the tools for studying breast cancer and to develop more effective preventive and therapeutic treatments, especially the growing use of animal models. To date, rodents-especially transgenic mice and ratsremain the most prevalent animal models for breast cancer, largely due to size, cost efficiency and litter sizes. Unfortunately, development of anti-cancer treatments in these models suffers from poor translation to humans, with many treatments working in the rodent models but failing in human clinical trials. Though there are many potential explanations for this

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“…An adenocarcinoma approximately 3 mm in diameter was reported in the breast tissue of a wild-caught tree shrew, Tupaia glis [7]'. These authors note that this was the only lesion seen in about 400 animals, 55 % of which were female.…”

Section: Introductionmentioning

confidence: 99%

Pseudotumor of the Orbit in a Prosimian Primate (Lesser Bushbaby; Galago senegalensis)

Haines¹,

Moncure²

1973

J Med Primatol

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Breast Cancer in a Tree Shrew (Tupaia glis)

Cited by 28 publications

References 1 publication

Characterization of spontaneous breast tumor in tree shrews (<I>Tupaia belangeri chinenesis</I>)

Characterization of spontaneous breast tumor in tree shrews (<I>Tupaia belangeri chinenesis</I>)

Generation and characterization of a breast carcinoma model by PyMT overexpression in mammary epithelial cells of tree shrew, an animal close to primates in evolution

Pseudotumor of the Orbit in a Prosimian Primate (Lesser Bushbaby; Galago senegalensis)

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