Pseudotumor of the Orbit in a Prosimian Primate
(Lesser Bushbaby; Galago senegalensis)

Haines, Duane E.; Moncure, C.W.

doi:10.1159/000460349

Cited by 10 publications

(9 citation statements)

References 9 publications

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“…Pseudoepitheliomatous (pseudocarcinomatous) hyperplasia of the skin was reported in 8 greater bush babies (Galago crassicaudatus, current taxonomic name O. crassicaudatus) and 7 pottos (Perodicticus potto) after topical administration of 7,12-dimethylbenz[a]anthracene (DMBA) plus a cocarcinogen (dodecylbenzene). 1,43,44 Although the chemical 7,12-DMBA plus a cocarcinogen was also shown to induce skin neoplasms in greater bush babies, 1,12,44,66,75,77 the cases of pseudoepitheliomatous hyperplasia were excluded based on the diagnosis of hyperplasia, which indicated that these lesions were not true neoplastic processes.…”

Section: Literature Review Resultsmentioning

confidence: 99%

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Neoplasia in Prosimians: Case Series from a Captive Prosimian Population and Literature Review

Remick¹,

Wettere

Williams

2009

Vet Pathol

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Neoplastic diseases in prosimians have been sporadically reported in the literature. To provide a comprehensive review of prosimian neoplasia, a retrospective evaluation of neoplasia in a large captive prosimian colony and an extensive literature review were performed. Primates that belong to the Order Primata, Suborder Prosimii with histologic evidence of neoplasia were included. One hundred twenty-three cases of spontaneous neoplasia were identified in 101 prosimians from the Duke Lemur Center, and 124 cases were reported in 116 prosimians in the literature. Overall, this review compiled a total of 247 neoplasms in 217 prosimians. Of the 217 affected animals, 88 of 217 were males (41%), 100 of 217 were females (46%), and sex was not reported in 29 of 217 (13%). Ages ranged from 2 days to 36 years. Prosimian families represented were Lemuridae (80/217 [37%]), Cheirogaleidae (61/217 [28%]), Galagidae (44/217 [20%]), Lorisidae (28/217 [13%]), and Indriidae (4/217 [2%]). The most commonly affected species were the gray mouse lemur (Microcebus murinus) (28/217 [13%]), thick-tailed greater bush baby (Otolemur crassicaudatus) (23/217 [11%]), and black lemur (Eulemur macaco) (19/217 [9%]). Organ systems affected, in order of descending occurrence, were digestive (75/247 [30%]), reproductive (40/247 [16%]), hematopoietic (34/247 [14%]), integumentary (28/247 [11%]), endocrine (26/247 [11%]), and urinary (17/247 [7%]). The respiratory, nervous, musculoskeletal, and cardiovascular systems were infrequently affected. The most common neoplasms were hepatocellular (32/247 [13%]), lymphoma and/or leukemia (29/247 [12%]), biliary (15/247 [6%]), and mammary neoplasms (12/247 [5%]). This article should serve as a valuable reference for the types and relative frequencies of neoplasms that occur in prosimian species.

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Section: Literature Review Resultsmentioning

confidence: 99%

“…,44,93 The pseudotumor was described as lymphoid, plasmacytic, and sclerosing. This case was excluded, because orbital pseudotumors are…”

mentioning

confidence: 99%

Neoplasia in Prosimians: Case Series from a Captive Prosimian Population and Literature Review

Remick¹,

Wettere

Williams

2009

Vet Pathol

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“…A mass designated as an orbital pseudotumor was described in a lesser bushbaby. 9 This mass developed within the bulbar conjunctiva at the limbus, was unencapsulated but easily separated from adjacent tissue, and consisted of a mixture of fibroblasts, plasma cells, lymphocytes, and scattered neutrophils. A similar mass, designated as a lacrimal pseudotumor, was reported in a young Bull Terrier.…”

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confidence: 99%

Inflammatory Myofibroblastic Tumors in Two Dogs

et al. 2009

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Two soft tissue masses from different locations in 2 dogs were submitted for histopathologic examination. Each was well demarcated and consisted of interweaving streams of bland spindle cells among which numerous plasma cells and lymphocytes were scattered. All the spindle cells reacted strongly to antibodies against vimentin and calponin, whereas a subset of the spindle cells expressed smooth muscle actin and desmin. Immunohistochemistry results were consistent with a myofibroblastic derivation for the spindle-cell population and the diagnosis of inflammatory myofibroblastic tumor (IMT) was made. This is the second report of IMT in the veterinary literature.

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“…They are well recognised in the human medical literature as focal, benign mass lesions that occur in a variety of locations; however, there is ongoing debate about their inflammatory versus neoplastic nature, which is reflected by numerous synonyms (Häusler et al, 2003). In veterinary medicine, case reports of IPTs are rare and most have been reported in the orbital cavity in cats and dogs (Haines and Moncure, 1973;Miller et al, 2000;Billson et al, 2006;van der Woerdt, 2008;Knight et al, 2009). IPT and IPT-like lesions have also been reported arising from the periorbita (Williams et al, 1998), subcutis (Miller et al, 1999;Wako et al, 2005;Knight et al, 2009) and thoracic and abdominal organs (Slocombe et al, 1992;Gartner et al, 2002;Boyle et al, 2004;Liu et al, 2005;Böhme et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

A primo vessel-like structure in a dog with inflammatory pseudotumor

Cho¹,

Shi²,

Han³

et al. 2012

Korean Journal of Veterinary Service

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Inflammatory pseudotumor (IPT) is a term defining a mass characterized microscopically by a proliferation of bland mesenchymal spindle cells infiltrated by diffuse mixed inflammatory cells with a predominance of plasma cells and lymphocytes. Here, we show the primo vessel-like structure of the primo-vascular system (PVS) in a dog with IPT. A 6-years old male Mongrel dog was diagnosed with an abnormal mass (diameter 5.5 cm, weight 22 g) near left preputial area. The dog was submitted to the surgical detectomy of the mass. During the surgical operation, we observed primo vessel-like material. After fixations, the masses appeared macroscopically as lipoid-like, firm, white to grey masses, measuring 5×8 cm. Histologically, cellular infiltration into the muscular layers was frequently seen. The mesenchymal proliferation remained the main component of the mass and was composed of myofibroblastic-like spindle cells characterized by globular, irregular nuclei containing open chromatin and a prominent nucleolus. On the basis of the histopathologic lesions, the subcutaneous mass was diagnosed as IPT. Also, we detected a primo vessel-like structures in some areas of the IPT tissues. These were observed as novel thread-like structures and bundle of tubular structures. To our knowledge, this report is the first case of primo vessel-like structure in a dog with IPT.

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Pseudotumor of the Orbit in a Prosimian Primate (Lesser Bushbaby; Galago senegalensis)

Abstract: A slowly growing mass appeared dorsolateral to the right eye of an adult female lesser bushbaby, Galago senegalensis. Surgically removed and examined histologically, the tumor showed combined histological features of lymphoid, plasmacytic and sclerosing orbital pseudotumors.

Cited by 10 publications

References 9 publications

Neoplasia in Prosimians: Case Series from a Captive Prosimian Population and Literature Review

Neoplasia in Prosimians: Case Series from a Captive Prosimian Population and Literature Review

Inflammatory Myofibroblastic Tumors in Two Dogs

A primo vessel-like structure in a dog with inflammatory pseudotumor

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