Breast Cancer in Men

Donegan, William L.; Redlich, Philip N.

doi:10.1016/s0039-6109(05)70443-6

Cited by 85 publications

(77 citation statements)

References 90 publications

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“…1-7 Some investigators report outcomes in men to be the same as in women, when patients are matched for histopathology, receptor state and disease stage. [3][4][5][6] Others suggest that men have poorer outcomes than women despite lower histologic grade, high ER content and small size. 6…”

Section: Discussionmentioning

confidence: 99%

“…These results are encouraging when compared to historic results of treatment with standard chemo-, radiation and hormonal therapy for patients with locally advanced disease. [1][2][3][4][5][6][7] However, evaluation of more cases and longer follow-up will be necessary to determine the incidence of late recurrence and possibility for cure in this population. The relative efficacy of standard and high-dose chemotherapy in men with breast cancer is probably not evaluable given the rarity of this disease.…”

Section: Discussionmentioning

confidence: 99%

“…3 The median age of men with breast cancer is 5 to 10 years older than women with breast cancer. [1][2][3][4][5][6][7] While 64% of premenopausal and 75% of post-menopausal women have estrogen receptor (ER) positive cancers and 58% and 53%, respectively, have progesterone receptor (PR) positive tumors, according to a large study by Clark and colleagues, 8 80-90% of men have ER and PR positive breast cancer. [1][2][3][4][5][6][7] Recent advances in the molecular biology of breast cancer have allowed detection of differences in the BRCA1 and BRCA2 mutations in hereditary and spontaneously occurring female and male breast cancers (reviewed in Refs 9 and 10).…”

mentioning

confidence: 99%

“…[1][2][3][4][5][6][7] Some investigators report outcomes in men to be the same as in women, when patients are matched for histopathology, receptor state and disease stage. [3][4][5][6] Others suggest that men have poorer outcomes than women despite lower histologic grade, high ER content and small size. 6 Increasing numbers of women now receive high-dose chemotherapy with autologous hematopoietic stem cell support (autotransplant) for both metastatic and high-risk stage 2/3 breast cancer.…”

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confidence: 99%

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Autotransplants in men with breast cancer

McCarthy

Hurd

Rowlings

et al. 1999

Bone Marrow Transplant

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Summary:The purpose of this study was to determine the outcome of high-dose therapy with autologous hematopoietic stem cell support (autotransplants) in men with breast cancer. We studied 13 men receiving autotransplants for breast cancer and reported to the Autologous Blood and Marrow Transplant Registry (ABMTR) by 10 centers. Six men had stage 2 breast cancer, four had stage 3, and three had metastatic breast cancer. Of twelve tumors tested, all were estrogen receptor positive. Median age at transplant was 50 years. The most common conditioning regimen was cyclophosphamide, thiotepa and carboplatin (n = 5); the remaining eight men received other alkylator-based regimens. Three men received bone marrow, eight received blood stem cells, and two received both for hematopoietic support. All patients had hematopoietic recovery. There were no unexpected regimen-related toxicities. Of 10 men receiving autotransplants as adjuvant therapy, three relapsed 3, 5 and 50 months post-transplant and died 16, 19 and 67 months post-transplant. Seven of 10 are disease-free with median follow-up of 23 months (range 6-50 months). Of three men treated for metastatic breast cancer, one had progressive disease and two recurrent disease at 6, 7 and 16 months post-transplant. In conclusion, results of autotransplants for male breast cancer appear similar to those reported for women receiving autotransplants for breast cancer. Keywords: male breast cancer; autotransplant Male breast cancer accounts for fewer than 1% of all breast cancers. The annual incidence is Ͻ1 per 100 000 males. 1,2 Stage at diagnosis is generally more advanced than in women, possibly as a result of delays in diagnosis. Anatomic factors may also contribute. 3 The median age of men with breast cancer is 5 to 10 years older than women with breast cancer. 1-7 While 64% of premenopausal and 75% of post-menopausal women have estrogen receptor (ER) positive cancers and 58% and 53%, respectively, have progesterone receptor (PR) positive tumors, according to a large study by Clark and colleagues, 8 80-90% of men have ER and PR positive breast cancer. [1][2][3][4][5][6][7] Recent advances in the molecular biology of breast cancer have allowed detection of differences in the BRCA1 and BRCA2 mutations in hereditary and spontaneously occurring female and male breast cancers (reviewed in Refs 9 and 10).The standard therapy of breast cancer in men is similar to treatment in women, including surgery, radiation, hormone therapy and chemotherapy. 1-7 Some investigators report outcomes in men to be the same as in women, when patients are matched for histopathology, receptor state and disease stage. [3][4][5][6] Others suggest that men have poorer outcomes than women despite lower histologic grade, high ER content and small size. 6

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Autotransplants in men with breast cancer

McCarthy

Hurd

Rowlings

et al. 1999

Bone Marrow Transplant

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“…The agonistic effect of tamoxifen on the endometrium is non-existent in men, and hot flushes, a common side effect in females, are less severe in male patients (5,39). However, its success does not mean that it is suitable in all cases, as tamoxifen leads to side effects in 62.5% of users (41). These side effects can range from mood changes and depression to more physical changes such as weight gain, hair loss and even impotence (4,8).…”

Section: Treatmentmentioning

confidence: 99%

Conditions of the male breast: Gynaecomastia and male breast cancer (Review)

et al. 2009

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Abstract. Breast disease most commonly affects females; however, a small percentage of men are also affected. understandably given its low incidence, awareness of male breast disease is low, particularly among the general population. We searched the Medline database from 1950 onwards using the search terms male, breast, neoplasms and gynaecomastia, and reviewed the conditions associated with male breast disease, examining some of the risk factors and discussing how these conditions are diagnosed and treated, and finally putting forward some suggestions for their future management.

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Interobserver Variation in the Assessment of Rosacea

Bamford¹

1998

Arch Dermatol

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Breast Cancer in Men

Cited by 85 publications

References 90 publications

Autotransplants in men with breast cancer

Autotransplants in men with breast cancer

Conditions of the male breast: Gynaecomastia and male breast cancer (Review)

Interobserver Variation in the Assessment of Rosacea

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