Breast Cancer in the Young Patient

Sariego, Jack

doi:10.1177/000313481007601226

Cited by 122 publications

(43 citation statements)

References 12 publications

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“…The phenotype, prognosis and molecular hallmarks of breast cancer are heterogeneous. Considering the markers of mammary epithelial cell states, it is possible to classify breast cancer into stemcell-like, basal and luminal cancer (3,4). Triple-negative breast cancer, which lacks estrogen receptors, progesterone receptors and human epidermal growth factor receptor-2 (HER-2) is the most malignant breast cancer, and effective treatments remain unavailable (5).…”

Section: Introductionmentioning

confidence: 99%

Lutein inhibits proliferation, invasion and migration of hypoxic breast cancer cells via downregulation of HES1

Zhang

Liu

et al. 2018

Int J Oncol

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An intratumoral hypoxic microenvironment is frequently observed in solid tumors, including breast cancer. Lutein, a plant-derived compound and non-vitamin A carotenoid, has been demonstrated to possess multiple protective properties including anti-inflammation, anti-oxidative stress and antitumor effects. The main objective of the present research was to elucidate the involvement of lutein in the production of reactive oxygen species (ROS) under hypoxia, the activation of hairy and enhancer of split 1 (HES1), and the proliferation, invasion and migration of breast cancer cells. The human breast cancer cell lines MDA‑MB‑157 and MCF‑7 were exposed to hypoxic conditions and various concentrations of lutein. An MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay was performed to examine cell proliferation, and Annexin V-fluorescein isothiocyanate/propidium iodide staining was performed to analyze the apoptosis ratio. The levels of hypoxia inducible factor-1α (HIF‑1α), NOTCH signaling molecules, HES1 and epithelial-mesenchymal transition (EMT)-associated factors were examined by reverse transcription-quantitative polymerase chain reaction and western blot analysis. Wound healing and Transwell invasion assays were used to detect the invasion and migration of breast cancer cells. Intracellular ROS levels were examined using 2,7-dichlorodihydrofluorescein-diacetate and flow cytometry. The results revealed that cell proliferation was inhibited by lutein in a dose-dependent manner, and the apoptosis ratio gradually increased with lutein treatment under hypoxia as evident from flow cytometry-based analysis. Exposure to lutein inhibited hypoxia-mediated activation of HIF‑1α, NOTCH signaling and HES1 expression, and suppressed the hypoxia-induced expression of EMT-associated factors. Lutein markedly inhibited the invasion and migration of breast cancer cells under hypoxia. Hypoxia-induced production of ROS was also decreased by lutein. Furthermore, the ROS scavenger N‑acetylcysteine also suppressed hypoxia inducible factor 1α and HES1 expression in breast cancer cells during hypoxia, but hydrogen peroxide (H2O2) levels were increased. Taken together, the results of the present study suggested that lutein may be a novel candidate for the chemoprevention of breast cancer. Furthermore, HES1 may be crucial in mediating the involvement of lutein in the suppression of hypoxia-driven ROS-induced breast cancer progression.

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Section: Introductionmentioning

confidence: 99%

Lutein inhibits proliferation, invasion and migration of hypoxic breast cancer cells via downregulation of HES1

Zhang

Liu

et al. 2018

Int J Oncol

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“…Worldwide, breast cancer is one of the most commonly‐diagnosed cancers in women (Sariego, ). In developing countries, such as China, the morbidity and mortality of breast cancer have been increasing over the past decades (World Health Organization, ; Kim et al, ).…”

Section: Introductionmentioning

confidence: 99%

Women's experiences of making healthcare decisions about their breast cancer: A phenomenological study

Xiong

Stone

Turale

et al. 2016

Nursing & Health Sciences

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There are few studies about how healthcare decisions are made for women with breast cancer in China and this knowledge is vital, both to further develop person-centered health care and to ensure that women have a voice in their healthcare decisions. This phenomenological study explored the meaning of women's lived experiences of making healthcare decisions about their breast cancer in China. Semistructured, in-depth interviews were conducted with a purposive sample of eight women with breast cancer. Data were analyzed using Colaizzi's phenomenological analytic method. The results of this study identified four themes: authority and expertise, lack of knowledge, family support, and Chinese cultural and social influences. Women were deferential to medical authority and perceived expertise, but they wanted to be involved to a greater degree in healthcare decisions. It is important for health professionals to optimize women's participation in decision-making by removing barriers and advocating on their behalf.

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“…It is a disease that afflicts hu-mans and other mammals. While the overwhelming majority of cases are women, men can also develop breast cancer [4].…”

Section: Introductionmentioning

confidence: 99%

Primary Study of the Use of Laser-Induced Plasma Spectroscopy for the Diagnosis of Breast Cancer

Imam¹,

Mohamed²,

Eldakrouri³

2012

OPJ

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Breast cancer, or malignant breast neoplasm, is a type of cancer that originates from breast tissue, most commonly from the inner lining of the milk ducts or the lobules that supply the ducts with milk. It is one of the most widespread diseases, especially in women. Thus far, large efforts have been towards the early diagnosis of cancer in general, and breast cancer specifically. Most of these techniques deal with malignant tissues without inducing or increasing pathological tissue changes or causing major side effects for the patient. This paper proposes a new technique for diagnosing the presence or occurrence of cancer and assessing its grade early, accurately, and safely. The presented technique depends on the interaction between the laser and the soft tissue in order to induce plasma, and allows us to classify the cancer by studying the difference in the intensity ratio of the trace elements in normal and malignant tissues. The results presented here are show that only four patients out of the total sample of 30 have erroneous trace elements and that this does not affect the overall decision. Hence, the performance of LIPS can be measured as 87%, while retaining 100% accuracy. Furthermore, LIPS technique is a simple and promising technique that is capable of diagnosing malignant cells and tissues

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Breast Cancer in the Young Patient

Cited by 122 publications

References 12 publications

Lutein inhibits proliferation, invasion and migration of hypoxic breast cancer cells via downregulation of HES1

Lutein inhibits proliferation, invasion and migration of hypoxic breast cancer cells via downregulation of HES1

Women's experiences of making healthcare decisions about their breast cancer: A phenomenological study

Primary Study of the Use of Laser-Induced Plasma Spectroscopy for the Diagnosis of Breast Cancer

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