Breast cancer incidence and mortality trends in 16 European countries

Botha, J. L.; Bray, Freddie; Sankila, Risto; Parkin, D M

doi:10.1016/s0959-8049(03)00118-7

Cited by 223 publications

(169 citation statements)

References 14 publications

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“…Time trends in breast cancer incidence depend on mammographic screening leading to earlier diagnosis, a shift in the distribution of the established risk factors of the population or better health awareness [22]. We demonstrated a dramatic reduction in one risk factor: the use of HRT.…”

Section: Discussionmentioning

confidence: 80%

Reduction in hormone replacement therapy use and declining breast cancer incidence in the Belgian province of Limburg

Vankrunkelsven

Kellen

Lousbergh

et al. 2009

Breast Cancer Res Treat

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Breast cancer is the most common female cancer in Europe, but its incidence and mortality are rapidly changing across Europe. The early termination of the women's health initiative (WHI) trial, after the detection of an increased breast cancer risk in hormone replacement therapy (HRT) users, was followed by strong declines of HRT use worldwide. We investigated whether the reduction of HRT sales affected breast cancer incidence in the Belgian province Limburg. All women registered in the Limburg Cancer Registry with a diagnosis of invasive breast cancer diagnosed between 1/1/1996 and 31/12/2005 were included in the study. Data on the use of HRT in the population were obtained from the vendors and the social security system. For age-standardization using the direct method, the European standard population was taken. In 2003 and 2004, the breast cancer incidence rate decreased significantly as compared to 2002 for women aged between 50 and 69 years. This sudden drop in the incidence intercepted a markedly increasing trend until 2002, but was followed again by an increase in 2005. Between 2002 and 2006, the sales of HRT (about 75% to women aged 50-69 years) were reduced by 41%. Breast cancer incidence was maximally related to HRT use in the previous year (R 2 = 77%). The decrease of breast cancer incidence in the Belgian province of Limburg may largely be related to the fall of HRT use following the early termination of the WHI trial. This suggests that HRT stimulates the growth of preexisting, clinically latent tumours that may not otherwise become clinically apparent.

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Section: Discussionmentioning

confidence: 80%

Reduction in hormone replacement therapy use and declining breast cancer incidence in the Belgian province of Limburg

Vankrunkelsven

Kellen

Lousbergh

et al. 2009

Breast Cancer Res Treat

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“…Various studies described an increase in breast cancer incidence rates in the last two to three decades for both, situations with and without organised mammography screening (Quinn and Allen, 1995;Chu et al, 1996;McCann et al, 1998;Kricker et al, 1999;Paci et al, 2002;Schouten et al, 2002;Botha et al, 2003;Buiatti et al, 2003). Where organised screening has been introduced, this increase is more marked, mainly as a result of the additional detection of early breast cancer stages.…”

Section: %mentioning

confidence: 99%

Decreased rates of advanced breast cancer due to mammography screening in The Netherlands

et al. 2004

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The effect of the implementation of the Dutch breast cancer screening programme during 1990 -1997 on the incidence rates of breast cancer, particularly advanced breast cancer, was analysed according to stage at diagnosis in seven regions, where no screening took place before 1990. The Netherlands Cancer Registry provided detailed data on breast cancer incidence in 1989 -1997 by tumour stage, age and region. Annual age-adjusted incidence rates of all breast cancers and advanced cancers, defined as large tumours T2 þ with lymph node and/or distant metastases, were compared with rates in 1989. In general, breast cancer incidence rose strongly in the early 1990s, especially in the age category 50 -69 years (estimated annual percentage change (EAPC) 4.25; 95% CI 1.70, 6.86). The increase was mainly due to the increase in small T1 cancers and ductal carcinoma in situ. However, in women aged 50 -69, advanced cancer incidence rates showed a significant decline by 12.1% in 1997 compared with 1989 (EAPC -2.14, 95% CI À3.47, À0.80), followed by a breast cancer mortality reduction of similar size after approximately 2 years. We confirm that breast cancer screening initially leads to a temporary strong increase in the breast cancer incidence, which is followed by a significant decrease in advanced diseases in the women invited for screening. It is evident that breast cancer screening contributes to a reduction in advanced breast cancers and breast cancer mortality.

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“…In Europe breast cancer incidence has increased in all countries with or without national screening programs [3], however despite this increase in the incidence of breast cancer, mortality has decreased by 1.8% annual during period 1997-2006 [9]. This reduction in the rates of mortality such Spain as in Europe has been attributed to mammography screening, implementation of effective hormone treatments and chemotherapy, and progress in radiotherapy and surgery, these innovations have probably contributed to the observed improvements in breast cancer survival in Europe [1], although the contribution of each factor in the mortality improvement is unknown [14,19].…”

Section: Introductionmentioning

confidence: 99%

Breast cancer mortality in Spain: Has it really declined for all age groups?

et al. 2012

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Introduction: Incidence in Spain due to breast cancer has increased over the last few years, nevertheless mortality has decreased, especially since 1992. Despite this general decrease in mortality, the intensity has been different in all age groups. The main objective of this paper is to fit the mortality due to breast cancer for different age groups in Spain during Results: We found an evident decreasing trend during the last few years of the fit (1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008), furthermore we expect a decrease in the mortality due to breast cancer during the years of the forecast. Despite this decrease, the mortality rates have different intensities for each age group. Younger and central ages groups can notice an evident decreasing trend and extend it to forecast, on the other hand, for older age groups the trend in mortality seems to be stable.

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Breast cancer incidence and mortality trends in 16 European countries

Cited by 223 publications

References 14 publications

Reduction in hormone replacement therapy use and declining breast cancer incidence in the Belgian province of Limburg

Reduction in hormone replacement therapy use and declining breast cancer incidence in the Belgian province of Limburg

Decreased rates of advanced breast cancer due to mammography screening in The Netherlands

Breast cancer mortality in Spain: Has it really declined for all age groups?

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