Breast Cancer Mortality in Young Women in Brazil

Abstract

ObjectiveMalignant breast cancer is the leading cause of death by cancer in young women. The study aimed to determine if breast cancer mortality among young women has increased between the period from 1996 to 2017 in Brazil.MethodsA time-series analysis of breast cancer mortality rate in young women (20–39 years old) was carried out. Mortality data, from 1996 to 2017, were collected from the Mortality Information System of the Health Ministry, and demographic data, from the Brazilian Institute of Geography and Statistics. Trends in mortality were performed by Joinpoint Regression, the spatial distribution of the mortality rate was done with the QGIZ Software version 2.18, and Spearman’s correlation coefficient was used to correlate the mortality rates with the Human Development Index.ResultsThere was an increase in breast cancer mortality rates in young women in the majority of Brazilian states, with an upward trend in all regions. The correlation with the Municipal Human Development Index, income, and education had a significant impact on the mortality rate for women from 30–39 years old in both time frames evaluated and for women from 20–29 years old, only from 1996 to 2000.ConclusionThe data obtained in the study, showed that even though the breast cancer mortality rate of young women is lower than women over 40 years old, it has been increasing in all regions of Brazil, mostly for women from 30–39 years old, suggesting that this group should be included in screening programs.

Risk Factors, Prognostic Factors, and Nomogram for Distant Metastasis in Breast Cancer Patients Without Lymph Node Metastasis

“…Although the N0 women at a young age were more likely to have DM, compared with elderly women, the young population, however, had better long-term outcomes than the elderly population (HR= 1:1.58; 95% CI: 1.03-2.44). This result was consistent with one recent large population-based epidemiological study in Brazil that young women had a lower rate of modality (31).…”

“…Although the N0 women at a young age were more likely to have DM, compared with elderly women, the young population, however, had better long-term outcomes than the elderly population (HR= 1:1.58; 95% CI: 1.03–2.44). This result was consistent with one recent large population-based epidemiological study in Brazil that young women had a lower rate of modality ( 31 ). On the contrary, in another study by Sabiani and colleagues, they concluded that patients at a young age (<35 years) had the lower estimated disease-free survival (DFS) and OS rate ( 22 ).…”

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“…Nearly 40% of breast cancers occur in patients aged over 65 years and 25% in patients aged over 70 years. As the global population ages, the number of older patients with breast cancer will continue to increase ( 2 , 4 ). Therefore, breast cancer in the elderly will represent a major public health issue during the next decades.…”

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