Breast cancer patients’ experiences of adherence and persistence to oral endocrine therapy: A qualitative evidence synthesis

Clancy, Caroline; Lynch, Johanna; OConnor, Pamela; Dowling, Maura

doi:10.1016/j.ejon.2019.101706

Cited by 47 publications

(73 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings are consistent with the results of Clancy et al (2020)(20) andLambert et al (2018)(19), who both identified that side effects had a considerable impact on quality of life and consequently adherence and persistence, and that there is a need for more follow-up care and support from health care professionals. The current review progresses previous reviews through its detailed examination of the specific relationship between side effects and adherence and persistence with HT, whereas earlier reviews of the qualitative literature simply aimed to identify studies which examined adherence and persistence.…”

supporting

confidence: 92%

The Impact of Medication Side Effects on Adherence and Persistence to Hormone Therapy in Breast Cancer Survivors: A Qualitative Systematic Review and Thematic Synthesis

Peddie¹,

Agnew²,

Crawford³

et al. 2021

Preprint

View full text Add to dashboard Cite

BACKGROUND: Hormone Therapy (HT) reduces the risk of breast cancer recurrence and mortality in breast cancer. Despite these clinical benefits, rates of HT non-adherence and non-persistence are high. Research suggests this may be due to the impact of HT side effects. However, little research has explored the individual contribution of side effects to non-adherence and non-persistence behaviours. Our aim is to review the literature on breast cancer survivors’ lived experiences of HT side effects and explore how these may be related to non-adherence and non-persistence behaviour.METHODS: Electronic searches were conducted from inception to May 2020, utilising Cochrane CENTRAL, Medline, Embase, Web of Science and PsycINFO databases. Searches included a combination of terms related to breast cancer, adherence, hormone therapy and side effects.RESULTS: Sixteen eligible papers were identified, and study quality was high. Data were thematically synthesised into four analytical themes, which encompassed 13 descriptive sub-themes: ‘Daily impact of side-effects’, ‘Role of Health Care Professionals’, ‘Managing HT side-effects’, and ‘Weighing up the pros and cons’.CONCLUSIONS: HT side effects significantly impact breast cancer survivor’s quality of life. A lack of support from healthcare providers leads to self-management strategies, which negatively affects adherence and persistence behaviour.

show abstract

supporting

confidence: 92%

The Impact of Medication Side Effects on Adherence and Persistence to Hormone Therapy in Breast Cancer Survivors: A Qualitative Systematic Review and Thematic Synthesis

Peddie¹,

Agnew²,

Crawford³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…This might be associated with a negative impact on persistence to treatment, as previously reported. 21 , 47 …”

Section: Discussionmentioning

confidence: 99%

Adherence to Adjuvant Tamoxifen in Mexican Young Women with Breast Cancer

Martínez-Cannon¹,

Castro-Sánchez²,

Barragán-Carrillo³

et al. 2021

PPA

View full text Add to dashboard Cite

Background Breast cancer (BC) in young women is characterized by an unfavorable prognosis in hormone receptor-positive/HER2-negative tumors, which may be explained by low rates of tamoxifen adherence. In Mexico, up to 14% of all BC diagnoses occur in young women and no data on tamoxifen adherence has been reported. Objective To estimate the rate of adherence to adjuvant tamoxifen in Mexican young women with BC (YWBC). Methods A cross-sectional survey was conducted at the National Cancer Institute in Mexico City, among YWBC (≤40 years at diagnosis) receiving adjuvant tamoxifen. Adherence was measured subjectively, through self-reported surveys, and objectively, through medication possession ratio (MPR). Descriptive statistics were used to analyze sociodemographic characteristics. To compare associations between patients’ characteristics and adherence, Chi-square test was used for categorical variables and Student’s t -test or Mann–Whitney U -test for quantitative variables. Results A total of 141 YWBC receiving adjuvant tamoxifen were included. Regarding subjective adherence, 95% expressed taking tamoxifen regularly, 70% reported missing 0 doses in the past 30 days, and 71.6% reported having adverse effects. Regarding objective adherence, 74.8% of patients had an MPR ≥80%. The association between subjective and objective adherence was statistically significant ( p = 0.004). Subjective adherence was associated with not skipping tamoxifen doses when feeling worse. Objective adherence was associated with having a stable job, not skipping tamoxifen doses when feeling worse, taking additional medications, and time on tamoxifen treatment. Fifty-six percent considered the information on tamoxifen to be insufficient and 37% not understandable. Conclusion In our study, high subjective and objective adherence rates to adjuvant tamoxifen were reported, although an important proportion of women reported high rates of adverse effects and not fully understanding the benefits of tamoxifen. Strategies to increase tamoxifen adherence may be even more important now that longer durations of treatment or further ovarian function suppression have become the standard of care in YWBC.

show abstract

“…Two recent reviews of qualitative research in this area (19,20) have identified that adherence to HT is negatively impacted by the presence and severity of side effects. However, these reviews were broad in scope, considering multiple patient-related factors (e.g.…”

Section: Introductionmentioning

confidence: 99%

The impact of medication side effects on adherence and persistence to hormone therapy in breast cancer survivors: A qualitative systematic review and thematic synthesis

et al. 2021

View full text Add to dashboard Cite

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Breast cancer patients’ experiences of adherence and persistence to oral endocrine therapy: A qualitative evidence synthesis

Cited by 47 publications

References 51 publications

The Impact of Medication Side Effects on Adherence and Persistence to Hormone Therapy in Breast Cancer Survivors: A Qualitative Systematic Review and Thematic Synthesis

The Impact of Medication Side Effects on Adherence and Persistence to Hormone Therapy in Breast Cancer Survivors: A Qualitative Systematic Review and Thematic Synthesis

Adherence to Adjuvant Tamoxifen in Mexican Young Women with Breast Cancer

The impact of medication side effects on adherence and persistence to hormone therapy in breast cancer survivors: A qualitative systematic review and thematic synthesis

Contact Info

Product

Resources

About