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ObjectivesSide effects from Hormone Therapy (HT) impact medication adherence in breast cancer survivors. Understanding the most distressing HT side effects and their impacts may inform the development and implementation of interventions to alleviate these side effects and maximise HT adherence. This study aimed to explore the lived experience of adjuvant HT and understand the impact of HT side effects on adherence in a sample of breast cancer survivors.MethodsTwenty-five female breast cancer survivors who were currently taking adjuvant HT participated in the study. One-to-one, online, semi-structured interviews were conducted to explore (i) specific side effects from HT and (ii) the impact of these side effects on HT adherence. Data were analysed using Thematic Analysis.ResultsThe most commonly reported side effects were sleep disturbance, hot flashes, anxiety, and joint pain. Data exploring the impacts of these side effects on HT adherence were thematically synthesised into four analytical themes: “A bitter pill to swallow,” “Seeking relief,” “Taking control,” and “The only way out is through.” These themes encompass 14 sub-themes that encapsulate participants’ daily struggle with HT side effects and the coping strategies developed to manage these.ConclusionAdverse side effects from HT, such as sleep disturbance, hot flashes, pain and anxiety, impair quality of life and increase the likelihood of participants’ becoming non-adherent to HT medication. In order to maximise HT adherence and reduce breast cancer mortality, HT side effects should be closely monitored to identify individuals who would benefit from targetted intervention strategies aimed at alleviating these side effects.

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Objective: There is growing global evidence for stark inequalities in the physical health status and life-expectancy of people with a mental health diagnosis. In most cases, physical activity (PA) is one of the most effective methods of maintaining physical and mental health.However, people with mental health challenges are less likely to adhere to recommended levels of PA, leading to a vicious cycle of poor physical and mental health. The objective of this paper is to assess if, and how cognitive-behavioural (CB) techniques increase adherence to PA in mental health populations.Method: Systematic review and narrative synthesis. Included studies detailed a behavioural change intervention which targeted PA using CB approaches, delivered to adults with a mental health condition as defined by DSM V or ICD-10. Adherence to the intervention AND physical activity was reported within RCT, cluster RCT, quasi-experimental, or controlled before and after study. Electronic searches conducted in MEDLINE, CINAHL, Cochrane Library (Trials), SPORTDiscus and PsycINFO.Results: Ten studies from seven countries were synthesised. Methodologically moderate to weak, all showed adherence to the intervention to be associated with increased levels of PA.All studies reported higher than average adherence to PA in the intervention groups.Discussion: CB interventions were associated with improved adherence to PA in international samples of people with mental health conditions. Studies adopting more robust designs are needed to quantify optimal interventions and impact, but this original synthesis is encouraging for researchers and clinicians alike looking to maximise the synergy between physical and mental health.