Breast cancer risk after diagnosis by screening mammography of nonproliferative or proliferative benign breast disease: a study from a population-based screening program

Castells, Xavier; Domingo, Laia; Corominas, Josep; Torà-Rocamora, Isabel; Quintana, María Jesús Mures; Baré, Marisa; Vidal, Carmen; Natal, Carmen; Sánchez, Mar; Saladié, Francina; Ferrer, Joana; Vernet, María del Mar; Servitja, Sònia; Rodríguez-Arana, Ana; Román, Marta; Espinàs, Josep Alfons; Sala, María

doi:10.1007/s10549-014-3208-z

Cited by 58 publications

(56 citation statements)

References 20 publications

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“…In keeping with findings from previous studies (5,17,25), there was no evidence from this study to support an association between obesity or family history and breast cancer risk among women with BBD overall. However, contrary to our finding of a null association between family history and breast cancer risk among women with proliferative BBD, several studies have provided evidence in support of elevated risk of breast cancer in relation to a positive family history of breast cancer (17,26,27). However, further studies are needed to confirm this.…”

Section: Discussioncontrasting

confidence: 99%

Association between lifestyle, menstrual/reproductive history, and histological factors and risk of breast cancer in women biopsied for benign breast disease

Arthur

Wang

et al. 2017

Breast Cancer Res Treat

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Purpose Women with benign breast disease (BBD) have an increased risk of subsequent breast cancer. However, whether conventional breast cancer risk factors influence risk of breast cancer among women with BBD is unclear. In this study, we investigated the associations of lifestyle, menstrual/reproductive, and histological factors with risk of breast cancer among women biopsied for BBD. Methods We conducted a case-control study, nested within a cohort of 15,395 women biopsied for BBD at Kaiser Permanente Northwest between 1971 and 2006. Cases were women who developed a subsequent invasive breast cancer during follow-up; controls were individually matched to cases on age at BBD diagnosis. A total of 526 case-control pairs were included in the study. We calculated crude and multivariable OR and 95% CI for the associations between lifestyle, menstrual/reproductive, and histological factors and breast cancer risk using conditional logistic regression. Results Compared to premenopausal women, postmenopausal women, had reduced risk of subsequent breast cancer (OR: 0.60; 95% CI: 0.39–0.94), whereas women who ever used hormone therapy had increased risk (OR: 3.61; 95% CI: 1.68–7.75), as did women whose BBD lesion showed atypical hyperplasia (OR: 5.56; 95% CI: 2.05–15.06). Smoking, BMI, early menarche, multiparity (>=4), history of oophorectomy, and extent of lobular involution were not associated with risk of breast cancer. Conclusion This study suggests that use of HRT and having atypical hyperplasia are associated with increased risk of breast cancer among women with BBD while postmenopausal women with BBD have a reduced risk.

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Section: Discussioncontrasting

confidence: 99%

Association between lifestyle, menstrual/reproductive history, and histological factors and risk of breast cancer in women biopsied for benign breast disease

Arthur

Wang

et al. 2017

Breast Cancer Res Treat

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“…16 Benign breast hyperplasia/BBD without atypia is associated with a nearly two-fold increased breast cancer risk. 17-20 The presence of histopathologic indices of abnormal proliferation (such as atypia and lobular carcinoma in situ) within an otherwise benign breast biopsy confers higher risks for future breast cancer: four-to-five-fold relative risk for atypia and ten-fold for LCIS. 18-24 Several studies have furthermore confirmed that biopsy-proven BBD is a risk factor for future breast cancer in both AA and WA women.…”

Section: Discussionmentioning

confidence: 99%

Association Between Benign Breast Disease in African American and White American Women and Subsequent Triple-Negative Breast Cancer

et al. 2017

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Importance African American (AA) women have a two-fold higher incidence of breast cancers that are negative for estrogen receptor, progesterone receptor and HER2/neu (triple negative breast cancer, TNBC) compared with White/Caucasian Americans (WA). TNBC likely arises from different pathogenetic pathways compared to non-TNBC, and benign breast disease (BBD) predicts for future non-TNBC. Objective To determine whether AA identity remained associated with TNBC among women with a prior diagnosis of BBD. Design Retrospective analysis; January 1, 1994-December 31, 2005; mean follow-up 10.2 years. Setting Henry Ford Health System in metropolitan Detroit, Michigan; an integrated multihospital, multispecialty health care system. Participants 2,588 AA and 3,566 WA patients age 40-70 years with biopsy-proven BBD diagnosed 1/1/1994 to 12/31/2005. Main Outcome Measures Subsequent breast cancer, stratified by phenotype. Results BBD detection and management were similar for the AA and WA patients. Subsequent breast cancers developed in approximately 4% of AA patients (mean 6.8 years following BBD diagnosis) and WA patients (mean 6.1 years). More than three-quarters of subsequent cancers in each subset were DCIS or Stage I. The 10-year probability estimate for developing TNBC was 0.56% (95% confidence interval 0.32-1.0) for AA versus 0.25% for WA (95% confidence interval 0.12-0.53). Among the 73 AA patients that developed subsequent invasive breast cancer, 24.2% were TNBC compared to 7.4% of the 111 subsequent invasive BC cases (p=0.0125) among the WA patients. Conclusion and Relevance AA identity persisted as a significant risk factor for TNBC in our study, the largest analysis to date of BBD and subsequent breast cancer phenotypes in a diverse patient population managed equitably. This suggests that AA identity is associated with inherent susceptibility for TNBC pathogenetic pathways.

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“…In their seminal study, Dupont and Page found no increased breast cancer risk among women with nonproliferative BBD [12]. However, more recent research has found modest increased risk of breast cancer among nonproliferative lesions [9, 17, 41]. Wang et al in a companion study to the National Surgical Adjuvant Breast and Bowel Project (NSABP) Breast Cancer Prevention Trail found that women in the “lower category” of BBD had 1.6 times the risk of breast cancer compared to healthy women [41].…”

Section: Discussionmentioning

confidence: 99%

“…al. found nonproliferative lesions conferred a 2.23 fold (95% CI: 1.86–2.68) increased risk of breast cancer in a population based screening cohort [9]. Few studies have investigated risk factors for both proliferative and nonproliferative lesions given the mixed findings among nonproliferative lesions related to breast cancer risk.…”

Section: Discussionmentioning

confidence: 99%

A prospective study of endometriosis and risk of benign breast disease

Farland

Tamimi

Eliassen

et al. 2016

Breast Cancer Res Treat

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Purpose Given the altered hormonal and inflammatory environment of women with endometriosis, several studies have suggested a positive association between endometriosis and breast cancer, although findings have been mixed. This study investigates the relationship between endometriosis and benign breast disease (BBD), benign lesions that are associated with an increased risk of breast cancer. Methods Among women in the Nurses’ Health Study II followed from 1991–2003 (n=76,393), we investigated the association between laparoscopically confirmed endometriosis and biopsy confirmed BBD. Cox proportional hazard models, adjusted for a priori potential confounding factors, were used to calculate hazard ratios (HR) and 95% confidence intervals (CI). Across follow-up, 2,011 BBD biopsies were collected and centrally reviewed by study pathologists (non-proliferative = 675, proliferative =1,336). Effect modification by infertility history and use of screening mammography was investigated. Results Endometriosis was associated with a modest increased risk of biopsy confirmed BBD in crude and multivariable adjusted models (HR:1.20, 95% CI:1.00–1.43). When evaluating subtypes of BBD, we did not see different associations for nonproliferative or proliferative BBD lesions, as endometriosis was associated with a modest increased risk for both (HR nonproliferative:1.15, 95% CI:0.84–1.57; HR proliferative:1.22, 95% CI:0.98–1.52). The association between endometriosis and proliferative BBD appeared strongest among women who had ever experienced infertility (HR: 1.50, 95% CI:1.12–2.03; P-value, test for heterogeneity=0.05). Sensitivity analyses investigating screening behaviors between those with and without endometriosis did not significantly alter results. Conclusion Endometriosis was associated with a modest increased risk of both proliferative and non-proliferative BBD, although future work should replicate this novel finding.

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Breast cancer risk after diagnosis by screening mammography of nonproliferative or proliferative benign breast disease: a study from a population-based screening program

Cited by 58 publications

References 20 publications

Association between lifestyle, menstrual/reproductive history, and histological factors and risk of breast cancer in women biopsied for benign breast disease

Association between lifestyle, menstrual/reproductive history, and histological factors and risk of breast cancer in women biopsied for benign breast disease

Association Between Benign Breast Disease in African American and White American Women and Subsequent Triple-Negative Breast Cancer

A prospective study of endometriosis and risk of benign breast disease

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