Breast cancer risk in relation to the joint effect of BRCA mutations and diet diversity

Ghadirian, Parviz; Narod, Steven A.; Fafard, Eve; Costa, Marcella Albaine Farias da; Robidoux, André; Nkondjock, André

doi:10.1007/s10549-008-0292-y

Cited by 24 publications

(23 citation statements)

References 35 publications

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“…The risk associated with BRCA mutations is so high that women are now recommended prophylactic total mastectomy, but a century ago the risk in women with the same mutations would have been approximately equivalent to that of women in the general population of North America and Western Europe today. Recent studies of French-Canadian families with inherited BRCA1/2 mutations have examined the aspects of lifestyle associated with breast cancer risk and found that total energy intake and weight gain since the age of 18 were positively associated with risk [159] and dietary vegetable and fruit diversity were negatively associated [160]. These studies indicate that exposures that determine progression to clinical disease can have a large effect and operate independently of the initiating factors.…”

Section: Environmental Exposuresmentioning

confidence: 99%

Epithelial cancers in the post-genomic era: should we reconsider our lifestyle?

Holly

Zeng

Perks

2013

Cancer Metastasis Rev

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The age-related epithelial cancers of the breast, colorectum and prostate are the most prevalent and are increasing in our aging populations. Epithelial cells turnover rapidly and mutations naturally accumulate throughout life. Most epithelial cancers arise from this normal mutation rate. All elderly individuals will harbour many cells with the requisite mutations and most will develop occult neoplastic lesions. Although essential for initiation, these mutations are not sufficient for the progression of cancer to a life-threatening disease. This progression appears to be dependent on context: the tissue ecosystem within individuals and lifestyle exposures across populations of individuals. Together, this implies that the seeds may be plentiful but they only germinate in the right soil. The incidence of these cancers is much lower in Eastern countries but is increasing with Westernisation and increases more acutely in migrants to the West. A Western lifestyle is strongly associated with perturbed metabolism, as evidenced by the epidemics of obesity and diabetes: this may also provide the setting enabling the progression of epithelial cancers. Epidemiology has indicated that metabolic biomarkers are prospectively associated with cancer incidence and prognosis. Furthermore, within cancer research, there has been a rediscovery that a switch in cell metabolism is critical for cancer progression but this is set within the metabolic status of the host. The seed may only germinate if the soil is fertile. This perspective brings together the different avenues of investigation implicating the role that metabolism may play within the context of post-genomic concepts of cancer.

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Section: Environmental Exposuresmentioning

confidence: 99%

Epithelial cancers in the post-genomic era: should we reconsider our lifestyle?

Holly

Zeng

Perks

2013

Cancer Metastasis Rev

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“…The research revealed a strong and significant interaction between BRCA mutations and diversity of vegetable and fruit intake (COR=0.27; 95 % CI=0.10-0.80; P=0.03) when the upper quartiles were compared to the lower quartiles. The authors concluded that vegetable and fruit diversity may be associated with a significant reduced risk of breast cancer among women with BRCA mutations [63].…”

Section: Nutritionmentioning

confidence: 99%

Effects of Complementary and Integrative Medicine on Cancer Survivorship

2015

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Cancer survivorship has become a topic of great interest in the past few years. Unfortunately, even with successful treatment as well as good follow-up care, many patients continue to experience unmet physical, emotional, and spiritual needs as well as having an unsettling fear, fear of recurrence, a fear which most survivors share, even many years after their treatment ended. As a result, patients are continually looking for additional ways to address these needs and fears. Among the most popular approach is the use of complementary and integrative medicine (CIM). Most studies on CIM use among cancer patients and survivors concentrate on symptom improvement and improvement of quality of life and do not touch a crucial question if these therapies can affect patients' survival in terms of prolongation of life. Interestingly, in recent years, there are a growing number of studies that suggest that approaches such as mind-body interventions, enhanced general nutrition, nutritional supplements, physical activity, and other CIM approaches may have a positive effect on survival of cancer patients. Although additional studies are needed to confirm these findings, given the low cost of these CIM interventions, their minimal risk, and the potential magnitude of their effects, these approaches might be considered as additional important tools to integrate into cancer survivorship care plans.

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“…Specifically, BMI was associated with BRCA-related breast cancer risk, and high diet quality was associated with a low risk of BRCA-related breast cancer (7)(8)(9). In addition, some studies reported that vegetable and fruit intakes were modifiers in developing breast cancer in BRCA mutation carriers (10). However, these findings are limited to Western populations.…”

Section: Introductionmentioning

confidence: 99%

Dietary intake and breast cancer among carriers and noncarriers of BRCA mutations in the Korean Hereditary Breast Cancer Study

Kim

Hyun

et al. 2013

The American Journal of Clinical Nutrition

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Background: Soy intake is associated with a lower risk of breast cancer. However, it is unclear whether the same reduction in risk associated with high soy intake is also applicable to familial or genetic breast cancer. Objective: The aim of this study was to assess the dietary factors among carriers and noncarriers of BRCA mutations in the Korean Hereditary Breast Cancer Study (KOHBRA). Design: The KOHBRA Study is an ongoing project composed of affected breast cancer patients and familial members of breast cancer cases with BRCA mutations. To assess the association between dietary diversity and breast cancer risk, an HR was estimated by comparing affected subjects with their familial nonaffected members. To assess the interaction between the combination of BRCA mutation and diet diversity, the case-only OR (COR) was estimated by comparing BRCA mutation carriers and noncarriers only in affected subjects. Results: Soy product intake was associated with a lower risk of breast cancer in carriers (HR: 0.39; 95% CI: 0.19, 0.79 for the highest quartile). The highest quartile of meat intake was associated with a higher risk of breast cancer regardless of BRCA mutation in carriers (HR: 1.97; 95% CI: 1.13, 3.44) and noncarriers (95% CI: 1.41; 1.12, 1.78). The associations of meat intake and soybean intake for breast cancer were more prominent in BRCA2 mutation carriers. In the analysis with only cases, the highest quartile of soy intake, but not meat intake, was associated with BRCA-related breast cancer (COR: 0.57; 95% CI: 0.36, 0.91). Conclusion: Our study suggests that soy product consumption is associated with lower breast cancer risk and it had an interaction with BRCA mutation. This trial was registered at clinicaltrials.gov as NCT00595348.

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Breast cancer risk in relation to the joint effect of BRCA mutations and diet diversity

Cited by 24 publications

References 35 publications

Epithelial cancers in the post-genomic era: should we reconsider our lifestyle?

Epithelial cancers in the post-genomic era: should we reconsider our lifestyle?

Effects of Complementary and Integrative Medicine on Cancer Survivorship

Dietary intake and breast cancer among carriers and noncarriers of BRCA mutations in the Korean Hereditary Breast Cancer Study

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