Dietary intake and breast cancer among carriers and noncarriers of BRCA mutations in the Korean Hereditary Breast Cancer Study

Ko, Kwang-Pil; Kim, Sung-Won; Hyun, Sung Pil; Park, Boyoung; Ahn, Yo Han; Lee, Jong Won; Lee, Min Hyuk; Kang, Eunyoung; Kim, Lee Su; Jung, Yongsik; Cho, Young Up; Lee, ByoungKil; Park, Sue Kyung

doi:10.3945/ajcn.112.057760

Cited by 37 publications

(36 citation statements)

References 33 publications

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“…After screening the titles and abstract, 2629 publications were excluded due to no relevant data, duplicates, reviews, case series, and the remaining 25 were considered as of potential values. Eleven of these 25 studies were excluded for duplicated data [26,27] and not providing risk estimates or 95%CI [28][29][30][31][32][33][34][35][36]. Finally, fourteen studies, including two large-scaled cohort studies [13,37] and twelve case-control studies [14][15][16][38][39][40][41][42][43][44][45][46], were eligible and included in this meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

Tofu intake is inversely associated with risk of breast cancer: A meta-analysis of observational studies

2020

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Observational studies on the association between tofu intake and breast cancer incidence have reported inconsistent results. We reviewed the current evidence and quantitatively assessed this association by conducting a dose-response meta-analysis. The electronic databases PubMed and EMBASE were searched for relevant studies published up to August, 2018. We included epidemiological studies that reported relative risks (RRs) or odds ratios (ORs) with 95% confidence intervals (CIs) for the association between tofu intake and breast cancer risk. A total of 14 studies (2 cohort studies, 12 case-control studies) were included in the meta-analysis. The overall OR of breast cancer for highest vs lowest intake of tofu was 0.78 (95% CI 0.69-0.88), with moderate heterogeneity (P = 0.011, I 2 = 49.7%). Dose-response analysis based on 5 case-control studies revealed that each 10 g/d increase in tofu intake was associated with 10% reduction in the risk of breast cancer (95% CI 7%-13%, P = 0.037, I 2 = 40.8%). In summary, our findings suggest an inverse doseresponse association between tofu intake and risk of breast cancer. However, owing to the limitations of case-control studies, more properly designed prospective studies are warranted to confirm this association.PLOS ONE | https://doi.org/10.1371/journal.pone.0226745 January 7, 2020 1 / 13 OPEN ACCESSCitation: Wang Q, Liu X, Ren S (2020) Tofu intake is inversely associated with risk of breast cancer: A meta-analysis of observational studies. PLoS ONE 15(1): e0226745. https://doi.org/10.

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Section: Resultsmentioning

confidence: 99%

Tofu intake is inversely associated with risk of breast cancer: A meta-analysis of observational studies

2020

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“…Dietary factors associated with increased BC risk included intake of total n-6 polyunsaturated fatty acids (PUFA) (Kiyabu et al, 2015), vitamin D deficiency or insufficiency (Shi et al, 2014a;Park et al, 2015a), high levels of serum cadmium (Nagata et al, 2013;Itoh et al, 2014;Ding et al, 2015), high intake of salt (Park et al, 2014b), sugar (Sulaiman et al, 2014), meat (Ko et al, 2013), and saturated fat and oils (Balasubramaniam et al, 2013;Wang et al, 2013a). In women with BC, the trace elements, cadmium, magnesium, copper, cobalt and lithium, were found in high levels.…”

Section: Dietary Factorsmentioning

confidence: 99%

“…High intake of dietary fiber was associated with decreased BC risk (Sulaiman et al, 2014) along with high levels of α-carotene, β-carotene, β-cryptoxanthin, lutein/ zeaxanthin (Wang et al, 2014a), and soy products or isoflavones (Ko et al, 2013;Li et al, 2013a;Wada et al, 2014) (Table 2). In addition, BC patients had significantly lower levels of manganese, aluminum, iron and titanium than women who did not have BC (Ding et al, 2015).…”

Section: Dietary Factorsmentioning

confidence: 99%

A Review of the Epidemiology of Breast Cancer in Asia: Focus on Risk Factors

Youn

Han

2020

Asian Pac J Cancer Prev

105

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Background and Aim: Breast cancer is the most prevalent cancer in women. To date, regional differences in breast cancer risk factors have not been identified. The aim of our review was to gain a better understanding of the role of risk factors in women with breast cancer in Asia. Methods: We conducted a PubMed search on 15 March 2016, for journal articles published in English between 2011 and 2016, which reported data for human subjects in Asia with a diagnosis of breast cancer. Search terms included breast neoplasm, epidemiology, Asia, prevalence, incidence, risk and cost of illness. Studies of any design were included, except for review articles and meta-analyses, which were excluded to avoid duplication of data. No exclusions were made based on breast cancer treatment. We reported the results using the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Results: A total of 776 abstracts were retrieved. After screening against the eligibility criteria, 562 abstracts were excluded. The remaining 214 abstracts, which were published between 2013 and 2015, were included in this review. Results were summarized and reported under three categories: incidence, prevalence or outcomes for breast cancer in Asia; modifiable risk factors; and non-modifiable risk factors. We found that the increased risk of breast cancer among participants from Asia was associated with older age, family history of breast cancer, early menarche, late menopause, high body mass index, being obese or overweight, exposure to tobacco smoke, and high dietary intake of fats or fatty foods. In contrast, intake of dietary fruits, vegetables, and plant-and soy-based products was associated with a decreased breast cancer risk. While based on limited data, when compared to women from the United States, women from Asia had a decreased risk of breast cancer. Conclusions: This review of 214 abstracts of studies in Asia, published between 2013 and 2015, confirmed the relevance of known non-modifiable and modifiable risk factors for women with breast cancer.

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“…Genetic susceptibility to breast cancer comprises inherited mutations of the BRCA 1 and BRCA 2 genes related to hereditary breast cancers. In addition, some studies reported that vegetable and fruit intakes were modifiers in developing breast cancer in BRCA mutation carriers [54]. …”

Section: Discussionmentioning

confidence: 99%

Pitaya Extracts Induce Growth Inhibition and Proapoptotic Effects on Human Cell Lines of Breast Cancer via Downregulation of Estrogen Receptor Gene Expression

Guimarães

Castro

Oliveira

et al. 2017

Oxidative Medicine and Cellular Longevity

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Breast cancer is one of the most prevalent cancers in the world and is also the leading cause of cancer death in women. The use of bioactive compounds of functional foods contributes to reduce the risk of chronic diseases, such as cancer and vascular disorders. In this study, we evaluated the antioxidant potential and the influence of pitaya extract (PE) on cell viability, colony formation, cell cycle, apoptosis, and expression of BRCA1, BRCA2, PRAB, and Erα in breast cancer cell lines (MCF-7 and MDA-MB-435). PE showed high antioxidant activity and high values of anthocyanins (74.65 ± 2.18). We observed a selective decrease in cell proliferation caused by PE in MCF-7 (ER+) cell line. Cell cycle analysis revealed that PE induced an increase in G0/G1 phase followed by a decrease in G2/M phase. Also, PE induced apoptosis in MCF-7 (ER+) cell line and suppressed BRCA1, BRCA2, PRAB, and Erα gene expression. Finally, we also demonstrate that no effect was observed with MDA-MB-435 cells (ER−) after PE treatment. Taken together, the present study suggests that pitaya may have a protective effect against breast cancer.

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Dietary intake and breast cancer among carriers and noncarriers of BRCA mutations in the Korean Hereditary Breast Cancer Study

Cited by 37 publications

References 33 publications

Tofu intake is inversely associated with risk of breast cancer: A meta-analysis of observational studies

Tofu intake is inversely associated with risk of breast cancer: A meta-analysis of observational studies

A Review of the Epidemiology of Breast Cancer in Asia: Focus on Risk Factors

Pitaya Extracts Induce Growth Inhibition and Proapoptotic Effects on Human Cell Lines of Breast Cancer via Downregulation of Estrogen Receptor Gene Expression

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