Breast cancer risk in women treated with augmentation mammoplasty (Review)

Stivala, Alessio; Libra, Massimo; Stivala, Franca; Perrotta, Rosario Emanuele

doi:10.3892/or.2012.1762

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…Many cases of breast carcinoma developing in the augmented breast have been reported to date [ 6 , 10 - 23 ]. Major cohort studies investigating the frequency of breast cancer following breast augmentation have reported rates ranging from 0.2% to 2.7% [ 24 ]. We herein reported a case of breast carcinoma that developed in the augmented breast following liquid silicon injection.…”

Section: Discussionmentioning

confidence: 99%

Breast carcinoma originating from a silicone granuloma: a case report

et al. 2015

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Breast carcinoma rarely occurs in cases of foreign body granulomas following liquid silicone injection. Although the Food and Drug Administration (FDA) banned the use of all silicone injection products in 1992, liquid silicone injection for breast augmentation continues to be performed illegally. We herein report a case of breast carcinoma following liquid silicone injection in a 67-year-old female.A total of 45 years after liquid silicone injection, the patient had felt a breast mass in the right breast. Mammography showed a smooth mass that retracted the right nipple. Due to the presence of a marked acoustic shadow caused by the granulomas, evaluating the mass on ultrasonography was difficult. However, magnetic resonance imaging (MRI) showed a lobulated mass under the right nipple. The mass exhibited low signal intensity (SI) on T1-weighted images and intermingled high and low SI on T2-weighted images. Heterogeneous early enhancement with central low intensity was noted on dynamic contrast-enhanced MRI. Several oval-shaped low SI structures in the adipose tissue and disruption of the pectoralis major muscle were also observed. We diagnosed the patient with invasive ductal carcinoma based on a stereotactic-guided Mammotome® (a vacuum-assisted biopsy system manufactured by DEVICOR MEDICAL JAPAN, Tokyo, Japan) biopsy and subsequently performed mastectomy and axillary lymph node dissection (with a positive result for the sentinel node biopsy). Histologically, invasive ductal carcinoma was observed in the silicone granuloma.The development of foreign body granulomas following breast augmentation usually makes it difficult to detect breast cancer; thus, various devices are required to confirm the histological diagnosis of breast lesions. The stereotactic-guided Mammotome® biopsy system may be an effective device for diagnosing breast cancer developing in the augmented breast.

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Section: Discussionmentioning

confidence: 99%

Breast carcinoma originating from a silicone granuloma: a case report

et al. 2015

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“…Breast augmentation surgery is one of the most popular cosmetic procedures for women and breast cancer is the most frequent cancer among women (Stivala et al 2012 ). Therefore, diagnoses of breast cancer in patients with breast augmentation will increase.…”

Section: Discussionmentioning

confidence: 99%

A case of synchronous multiple bilateral breast cancer after breast augmentation

et al. 2015

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Breast cancer after breast augmentation is not rare, but cases of bilateral breast cancer after augmentation are not often reported. A 43-year-old woman attended our hospital because of a mass in her left breast. She had undergone breast augmentation by implants 4 years before at a cosmetic surgery clinic. There were operative scars in her bilateral axilla. A detailed examination revealed bilateral breast cancer, and we performed nipple-sparing mastectomy in both breasts. Sentinel lymph node biopsy using dye was performed and it identified stained lymph nodes on both sides. The sentinel lymph node biopsy was negative for metastasis on both sides, so axillary lymph node dissection was not performed.

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“…Breast implants are not associated with any increase in the risk of breast carcinoma; however, detection of abnormalities and breast screening can be more difficult, leading to potential delays in diagnosis . There are, however, radiological techniques for displacement of the implant to allow mammography without risk of damage to the implant …”

Section: Changes Following Breast Augmentationmentioning

confidence: 99%

Modern therapies and iatrogenic changes in breast pathology

Provenzano

Pinder

2016

Histopathology

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Iatrogenic changes within the breast can provide challenges for the histopathologist in routine practice. Diagnostic procedures, such as core biopsies, result in reactive changes and can cause displacement of benign and malignant cells, the interpretation of which may cause difficulties in the resection specimen. Breast augmentation surgery with implants or injection of fillers, performed for cosmetic reasons or as part of a reconstructive process following removal of breast cancer, also produces reactive changes locally and at distant sites that may mimic cancer. The entity of implant-associated anaplastic large-cell lymphoma is now well recognized, with progress in our understanding of the underlying biological factors that drive its development. Chemotherapy and radiotherapy used in the treatment of breast cancer causes characteristic changes in normal breast tissue, and can alter the histological appearance and receptor status of the tumour. Radiotherapy to the breast, for breast cancer or childhood malignancies, increases the risk of developing a secondary malignancy in the breast long after treatment. In this review, we describe some of the iatrogenic changes that may be seen in histological specimens from the breast.

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Breast cancer risk in women treated with augmentation mammoplasty (Review)

Cited by 4 publications

References 15 publications

Breast carcinoma originating from a silicone granuloma: a case report

Breast carcinoma originating from a silicone granuloma: a case report

A case of synchronous multiple bilateral breast cancer after breast augmentation

Modern therapies and iatrogenic changes in breast pathology

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