Breast cancer screening and the changing population pyramid of Japan

Uchida, Keiji; Ohashi, Hitoshi; Kinoshita, Satoki; Nogi, Hiroko; Kato, Kumiko; Toriumi, Yasuo; Yamashita, Akinori; Kamio, Makiko; Mimoto, Rei; Takeyama, Hiroshi

doi:10.1007/s12282-013-0470-6

Cited by 35 publications

(29 citation statements)

References 6 publications

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“…In addition, high-grade DCIS corresponded to 49.4% of cases in a previous report [1] but only 18.8% in this study. These differences may exist due to the low rate of breast cancer screening in Japan, which is lower than that in other countries at 40% [29]. The fact that various risk factors are lower than those reported previously may indicate that, in many cases, invasion already occurred at the time the patient presented to the hospital.…”

Section: Discussionmentioning

confidence: 79%

The Effect of Smoking on Progression From Ductal Carcinoma in Situ to Invasive Ductal Carcinoma: A Retrospective Study

Takada

Kashiwagi

Asano

et al. 2020

Preprint

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Background:If ductal carcinoma in situ (DCIS) is diagnosed by histological examination such as core needle biopsy or vacuum-assisted biopsy (VAB), invasion is often found by removing the entire tumor and performing pathological examination. According to a meta-analysis, the rate of invasion found by postoperative pathological examination is about 25%. Smoking is a risk factor for carcinogenesis in various carcinomas, including breast cancer. We examined the correlation between the risk of invasion found by postoperative pathology and smoking history in patients who were diagnosed with DCIS by preoperative biopsy.Methods:In this study, we examined 128 patients who were diagnosed with DCIS by preoperative biopsy. Before the biopsy, all patients were asked about the duration of smoking, number of cigarettes smoked per day, and whether they were currently smoking. The data were used to calculate each patient’s tobacco exposure based on pack-years. The statistical analyses included the Pearson’s chi-square test and logistic analysis. Multivariate analysis was performed on the risk factors for invasion diagnosed by postoperative pathological examination in all cases diagnosed with DCIS by preoperative biopsy.Results: Of all the patients included in this study, 107 (83.5%)neversmoked, which represented the majority, while8 patients (6.3%) smoked at diagnosis with DCIS, and 13 (10.2%) had quit smokingbefore diagnosis.Tobacco exposure was 10 or less pack-years for11 patients (8.6%) and more than 10 pack-years for10 patients (7.8%). Number of pack-years was not an independent factor (p=0.349, odds ratio [OR]=0.329), but current smoker status (p=0.006, OR=not calculable) was an independent factor with VAB (p=0.018, OR=0.327).Conclusions: This study suggests that tobacco components may have an influence on the progression from DCIS to invasive ductal carcinoma.

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Section: Discussionmentioning

confidence: 79%

The Effect of Smoking on Progression From Ductal Carcinoma in Situ to Invasive Ductal Carcinoma: A Retrospective Study

Takada

Kashiwagi

Asano

et al. 2020

Preprint

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“…The identified outcome rate was significantly lower in women aged 40-49 years than in women aged 50-74 years. The reason for this may be a higher examination rate for breast cancer in women aged <50 years in Japan (MHLW, 2011;Uchida et al, 2015). Second, we did not consider the screening interval and the availability of previous mammograms that have been mentioned to be associated with false-positive results (Hubbard et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Features of Microcalcifications on Screening Mammography in Young Women

Fushimi¹,

Fukushima

Suzuki

et al. 2018

Asian Pac J Cancer Prev

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Background: There is no decrease in the number of breast cancer deaths if screening mammography is performed in women aged <40 years. However, NCCN guidelines recommend screening mammography in young women at risk of hereditary breast cancer. Therefore, more accurate screening mammography for young women is needed. Objective: To evaluate the features of screening mammographic findings, particularly microcalcifications, in women aged <50 years to increase the positive predictive value of screening mammography in young women. Methods: We retrospectively reviewed the data of consecutive women who underwent opportunistic and organized breast cancer screening at the Sakuragaoka Hospital (Shizuoka, Japan) between April 2013 and March 2015. We compared the mammographic findings and features of microcalcifications between women aged <40 and 40–49 years and those aged 50–74 years. Results: The study included 3645 women. Of these 3645 women, 415 (11.4%) were aged <40 years, 1219 (33.4%) were aged 40–49 years, and 2011 (55.2%) were aged 50–74 years. Women aged <50 years were more likely to be recalled for microcalcifications than those aged 50–74 years (<40 years, 4.8%; 40–49 years, 4.3%; 50–74 years, 3.3%). Young women were more likely to be recalled for small round and segmental microcalcifications [<40 years, odds ratio (OR): 1.799 (95% CI: 0.751–2.846); 40–49 years, OR: 1.394 (95% CI: 0.714–2.074)] and less likely to be recalled for small round and grouped microcalcifications [<40 years, OR: 0.603 (95% CI: 0.181–1.025); 40–49 years, OR: 0.961 (95% CI: 0.496–1.428)] compared with women aged 50–74 years. Conclusions: On screening mammography, women aged <50 years had a higher tendency to be recalled for microcalcifications, particularly small round and segmental microcalcifications. False-positive results may be reduced by reflecting the characteristics of microcalcification findings among young women without breast cancer in the future.

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“…Thus, patients aged 65 years had a larger tumor size at diagnosis (16.5 cm versus 11.4 cm) and were underwent laparotomic surgery more frequently (92.1% versus 74.5%) compared to patients aged <65 years. A low medical checkup rate in the elderly patients has also been observed in a variety of malignancies [18,19]. According to a questionnaire survey about breast cancer in Japan [19], concerns about screening were high in the young women and low in the elderly women; the check-up rate was 16.0-20.0% in women aged 65-74 years and 43.0-46.0% in women aged 40-54 years.…”

Section: Discussionmentioning

confidence: 99%