Breast carcinomas of low malignant potential

Schnitt, Stuart J.; Fend, Falko; Decker, Thomas

doi:10.1007/s00428-021-03163-w

Cited by 16 publications

(26 citation statements)

References 66 publications

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“…54 It usually affects women of postmenopausal age (median age 64). 55 Histologically, TCCRP is composed of tall columnar mitochondrion-rich to oxyphilic cells arranged in nests with a predominant follicle-like/solid papillary pattern. The nuclei are located at the apical rather than the basal pole of the cells, evidencing the reverse polarization.…”

Section: Tall Cell Carcinoma With Reversed Polaritymentioning

confidence: 99%

“…56 TCCRPs are usually triple negative for ER, PR, and HER2. 55 Some cases may demonstrate weak hormone receptor positivity and expression of ARs. Co-expression of high and low-molecular-weight CKs is recognized as a desirable diagnostic criterion in the WHO classification.…”

Section: Tall Cell Carcinoma With Reversed Polaritymentioning

confidence: 99%

“…TCCRP is a low grade triple negative breast carcinoma with an indolent clinical course and a favorable prognosis. 55 Axillary lymph node metastases and/or distant metastases rarely occur. 63 Conservative surgery is the first line treatment for TCCRP.…”

Section: Tall Cell Carcinoma With Reversed Polaritymentioning

confidence: 99%

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Low-Grade Invasive Triple Negative Breast Carcinoma

Shaker¹,

Ding²,

Wang³

2022

J Clin Transl Pathol

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Triple-negative breast carcinomas (TNBCs) are defined as estrogen receptor-negative, progesterone receptor-negative, and human epidermal growth factor receptor 2-negative breast carcinomas and are composed of a heterogeneous group of breast carcinomas with most of them having aggressive behavior and poor prognosis. However, some TNBC cases are low grade with indolent clinical outcome and low risk of metastasis to other organs or regional lymph nodes. Lowgrade TNBCs include low-grade adenosquamous carcinoma, fibromatosis-like metaplastic carcinoma, low-grade invasive (ductal or lobular) carcinoma with apocrine differentiation, classic adenoid cystic carcinoma, secretory carcinoma, tall cell carcinoma with reversed polarity, acinic cell carcinoma, and low-grade mucoepidermoid carcinoma. This review aims to summarize the clinicopathological correlation and the molecular features of low-grade special TNBC subtypes.

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Section: Tall Cell Carcinoma With Reversed Polaritymentioning

confidence: 99%

Section: Tall Cell Carcinoma With Reversed Polaritymentioning

confidence: 99%

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Low-Grade Invasive Triple Negative Breast Carcinoma

Shaker¹,

Ding²,

Wang³

2022

J Clin Transl Pathol

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“…Size at presentation is usually small, with most of the cases being around 2 cm, but in a few cases the size can increase up to 8.6 cm. 103 On radiological examination, LGASC can be overdiagnosed 104 as conventional invasive carcinoma.…”

Section: A D E N O M Y O E P I T H E L I O M a ( A M E )mentioning

confidence: 99%

“…Local recurrences are described in cases treated by local excision alone, 106,110 with no attention paid to clear margins. 103 One death is on record 106 related to local thorax invasion. Rare cases have been described to transform into conventional, aggressive metaplastic carcinoma.…”

Section: A D E N O M Y O E P I T H E L I O M a ( A M E )mentioning

confidence: 99%

Breast lesions with myoepithelial phenotype

et al. 2022

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Myoepithelial cells (MECs) constitute a continuous layer of cells surrounding the breast glands, localised between the epithelial cells (ECs) and the basal membrane. MECs play important roles in normal mammary gland as they produce basal membrane and stimulate secretion. During neoplastic transformation, MECs act as a barrier preventing stromal invasion. MECs themselves can undergo a great variety of changes, ranging from hyperplastic to metaplastic, to neoplastic, and giving rise to a wide spectrum of morphological pictures sometimes difficult to interpret on routine diagnoses. Several benign and malignant breast tumours can present features of MECs differentiation. As these latter tumours are quite infrequent, the purpose of the present study is to offer a review of the morphological spectrum of MECs lesions, with correlations to prognosis.

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Triple-negatives Mammakarzinom

Sinn

Varga

2023

Pathologie

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Breast carcinomas of low malignant potential

Cited by 16 publications

References 66 publications

Low-Grade Invasive Triple Negative Breast Carcinoma

Low-Grade Invasive Triple Negative Breast Carcinoma

Breast lesions with myoepithelial phenotype

Triple-negatives Mammakarzinom

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