Breast-conserving therapy with partial or whole breast irradiation: Ten-year results of the Budapest randomized trial

Polgár, Csaba; Fodor, János; Major, Tibor; Sulyok, Zoltán; Kásler, Miklós

doi:10.1016/j.radonc.2013.05.008

Cited by 326 publications

(210 citation statements)

References 33 publications

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“…2 At a median follow-up of 10.2 years, 5.5% had an in-breast recurrence, but no further analysis by age was done. 3 In the University of Florence trial, 15.8% of the 260 randomized to intensity modulated radiation therapy (IMRT) APBI were b50 years old. With a median follow-up of 5 years, 1.5% had an in-breast recurrence and age was not a significant factor associated with recurrence.…”

Section: Resultsmentioning

confidence: 99%

Accelerated Partial Breast Irradiation: Executive summary for the update of an ASTRO Evidence-Based Consensus Statement

Correa

Harris

Leonardi

et al. 2017

Practical Radiation Oncology

525

342

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Section: Resultsmentioning

confidence: 99%

Accelerated Partial Breast Irradiation: Executive summary for the update of an ASTRO Evidence-Based Consensus Statement

Correa

Harris

Leonardi

et al. 2017

Practical Radiation Oncology

525

342

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“…For breast treatments accelerated partial breast irradiation (APBI) is proven to have at least comparable outcome to established whole breast treatment schemes 5, 6, 7…”

Section: Introductionmentioning

confidence: 99%

Electromagnetic tracking (EMT) technology for improved treatment quality assurance in interstitial brachytherapy

Kellermeier

Herbolzheimer

Kreppner

et al. 2017

J Applied Clin Med Phys

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Electromagnetic Tracking (EMT) is a novel technique for error detection and quality assurance (QA) in interstitial high dose rate brachytherapy (HDR‐iBT). The purpose of this study is to provide a concept for data acquisition developed as part of a clinical evaluation study on the use of EMT during interstitial treatment of breast cancer patients. The stability, accuracy, and precision of EMT‐determined dwell positions were quantified. Dwell position reconstruction based on EMT was investigated on CT table, HDR table and PDR bed to examine the influence on precision and accuracy in a typical clinical workflow. All investigations were performed using a precise PMMA phantom. The track of catheters inserted in that phantom was measured by manually inserting a 5 degree of freedom (DoF) sensor while recording the position of three 6DoF fiducial sensors on the phantom surface to correct motion influences. From the corrected data, dwell positions were reconstructed along the catheter's track. The accuracy of the EMT‐determined dwell positions was quantified by the residual distances to reference dwell positions after using a rigid registration. Precision and accuracy were investigated for different phantom‐table and sensor‐field generator (FG) distances. The measured precision of the EMT‐determined dwell positions was ≤ 0.28 mm (95th percentile). Stability tests showed a drift of 0.03 mm in the first 20 min of use. Sudden shaking of the FG or (large) metallic objects close to the FG degrade the precision. The accuracy with respect to the reference dwell positions was on all clinical tables < 1 mm at 200 mm FG distance and 120 mm phantom‐table distance. Phantom measurements showed that EMT‐determined localization of dwell positions in HDR‐iBT is stable, precise, and sufficiently accurate for clinical assessment. The presented method may be viable for clinical applications in HDR‐iBT, like implant definition, error detection or quantification of uncertainties. Further clinical investigations are needed.

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“…(67,68,69,70) For APBI, the NCCN guidelines recommend a hypofractionated schedule of 34 Gy divided into 10 fractions delivered twice daily in 5 days for brachytherapy or 38.5 Gy in 10 twice daily fractions with external beam RT to the tumor bed. (9) In the American Society for Radiation …”

Section: Accelerated Partial Breast Irradiationmentioning

confidence: 99%

Radiation Therapy Following Breast Conserving Surgery for Ductal Carcinoma in situ: Yes or No?

Stoleru¹,

Stoleru²

2017

chr

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RezumatCarcinomul ductal in situ al sânului este un precursor non-invaziv al cancerului mamar şi este reprezentat de un grup de leziuni cu potenţial malign variabil. Tratamentul local optim pentru pacientele cu carcinom ductal in situ rãmane un subiect controversat, în ciuda rezultatelor provenite din mai multe trialuri randomizate. Radioterapia care urmeazã intervenţiei chirurgicale conservatoare reduce aproximativ la jumãtate riscul de recidivã localã, dar nu are impact în ceea ce priveşte supravieţuirea pe termen lung. Studiile clinice desfãşurate pânã în prezent nu au putut identifica un subgrup de paciente cu carcinom ductal in situ cu risc scãzut, la care sã se poata renunţa în siguranţã la radioterapie, dupã intervenţia chirurgicala conservatoare. În lucrare sunt prezentate rezultate ale studiilor clinice în care s-a utilizat chirurgia conservatoare a sânului urmatã sau nu de radioterapie. Alte subiecte abordate se referã la stabilirea indicaţiei terapeutice în cazul carcinomului ductal in situ cu risc scãzut şi la noi tendinţe în radioterapia pentru carcinomul ductal in situ. Review Articlebreast cancerand represents a heterogenous group of lesions with different malignant potential. Despite several randomized trials, there is still controversy regarding the optimal local treatment for DCIS patients. The addition of radiotherapy after breast conserving surgery approximately halves the local recurrence risk but has no impact on long-term survival. Clinical studies failed to identify a low risk subgroup of DCIS patients treated with breast conserving surgery in whom radiotherapy can be safely omitted. Results of clinical trials of breast conserving surgery ± radiotherapy are summarized. Treatment decision making in low risk DCIS and current tendencies in the radiotherapy for DCIS are other issues addressed in this paper.

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Breast-conserving therapy with partial or whole breast irradiation: Ten-year results of the Budapest randomized trial

Cited by 326 publications

References 33 publications

Accelerated Partial Breast Irradiation: Executive summary for the update of an ASTRO Evidence-Based Consensus Statement

Accelerated Partial Breast Irradiation: Executive summary for the update of an ASTRO Evidence-Based Consensus Statement

Electromagnetic tracking (EMT) technology for improved treatment quality assurance in interstitial brachytherapy

Radiation Therapy Following Breast Conserving Surgery for Ductal Carcinoma in situ: Yes or No?

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