2014
DOI: 10.1016/j.mayocp.2013.12.014
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Breast Density and Breast Cancer Risk: A Practical Review

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Cited by 97 publications
(76 citation statements)
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“…Mammography remains the cornerstone for early breast cancer detection, 3,4 and the transition from screenfilm to digital mammograms (DMs) has enhanced the potential for imaging-based measures. In particular, image-derived indices of breast density 5,6 and parenchymal texture patterns 7 have emerged as promising risk factors for breast cancer in epidemiologic studies, paving the way toward personalized recommendations regarding women's cancer risk evaluation and screening. 8 Breast density, which measures the amount of fibroglandular tissue within the breast, is a key biomarker not only because it is considered a well-established independent risk factor for breast cancer, 5 but also because it influences the sensitivity of screening mammography.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Mammography remains the cornerstone for early breast cancer detection, 3,4 and the transition from screenfilm to digital mammograms (DMs) has enhanced the potential for imaging-based measures. In particular, image-derived indices of breast density 5,6 and parenchymal texture patterns 7 have emerged as promising risk factors for breast cancer in epidemiologic studies, paving the way toward personalized recommendations regarding women's cancer risk evaluation and screening. 8 Breast density, which measures the amount of fibroglandular tissue within the breast, is a key biomarker not only because it is considered a well-established independent risk factor for breast cancer, 5 but also because it influences the sensitivity of screening mammography.…”
Section: Introductionmentioning
confidence: 99%
“…In particular, image-derived indices of breast density 5,6 and parenchymal texture patterns 7 have emerged as promising risk factors for breast cancer in epidemiologic studies, paving the way toward personalized recommendations regarding women's cancer risk evaluation and screening. 8 Breast density, which measures the amount of fibroglandular tissue within the breast, is a key biomarker not only because it is considered a well-established independent risk factor for breast cancer, 5 but also because it influences the sensitivity of screening mammography. 9 Its critical role has motivated multiple approaches toward its assessment in DMs, from visual categorical assessment 10 and interactive quan-titative techniques 11 to fully automated measurements.…”
Section: Introductionmentioning
confidence: 99%
“…57,58 Gamma detectors are used to image the breast after injection of a radiotracer, technetium sestamibi, which has preferential uptake in highly proliferating tumor cells, thereby identifying functional differences in tumors from normal breast tissue. [58][59][60] Breast-specific γ imaging uses a dedicated, single-head, scintillating sodium iodide detector. Molecular breast imaging is the latest generation of systems and uses cadmium zinc telluride detectors in a dual-head configuration.…”
Section: Molecular-based Imagingmentioning
confidence: 99%
“…58 However, biopsy units guided by molecular breast imaging are in development. 58,60 Advantages of molecular-based imaging over MRI include its lower cost and fewer contraindications.…”
Section: Molecular-based Imagingmentioning
confidence: 99%
“…The American College of Radiology (ACR) (24) is the copyright owner of a work entitled "Breast Imaging Reporting and Database System (BI-RADS ® )" that contains a guide for the standardized mammographic opinion, including a lexicon of terminology, an organization of medical report as well as an evaluation framework and coding system ( According to a study by Boyd (25) and later confirmed by several other studies (26,27), it was found that breast density is the most important factor that influences the mammographic sensitivity. These final studies were based on the concept of exposure of breast tissue as a relevant measure for cancer incidence.…”
Section: Lexicons and Terminologiesmentioning
confidence: 99%