Breast Feeding Modifies Production of SlgA Cow's Milk‐Antibodies in Infants

Renz, Harald; Brehler, C.; Petzoldt, S.; Prinz, Helge; Rieger, Christian

doi:10.1111/j.1651-2227.1991.tb11825.x

Cited by 16 publications

(7 citation statements)

References 10 publications

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“…Human milk reduces the risk for infections, with a greater effect in non-atopic than in atopic infants (1,2). Human colostrudmilk enhances gut maturation and provides passive protection for bacteria and antigens (allergens) by specific secretory IgA and other protecting factors (3,4), even after a short nursing period of only 3 weeks (5). However, most of the beneficial effects of breast milk are only related to fresh milk (6), although the incidence of cow's milk protein allergy (CMPA) in infants fed own mother's milk or pasteurized pooled human milk was also reported equal (1.7%) (7).…”

Section: Y Vandenplas Az-kinderen Free University Of Brussels Lamentioning

confidence: 99%

Myths and facts about breastfeeding: Does it prevent later atopic disease?

Vandenplas¹

1998

Nutrition Research

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Section: Y Vandenplas Az-kinderen Free University Of Brussels Lamentioning

confidence: 99%

Myths and facts about breastfeeding: Does it prevent later atopic disease?

Vandenplas¹

1998

Nutrition Research

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“…Not only do these Abs provide passive protection against infections, but they might also actively shape childhood immunity and tolerance induction by providing the fetus and the infant with the mother's immunological experience (12). In this regard, the diaplacental transfer of IgG Abs and the presence of high amounts of secretory IgA Abs in breast milk might play an important role (13). However, whether the T cell compartment might also be actively involved in regulating pre-and postnatal immunity has not been extensively studied to date.…”

mentioning

confidence: 99%

Critical Role of Preconceptional Immunization for Protective and Nonpathological Specific Immunity in Murine Neonates

Uthoff

Spenner

Reckelkamm

et al. 2003

The Journal of Immunology

111

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Expression of Th2 immunity against environmental Ags is the hallmark of the allergic phenotype and contrasts with the Th1-like pattern, which is stably expressed in healthy adults throughout life. Epidemiological studies indicate that the prenatal environment plays an important and decisive role in the development of allergy later in life. Since the underlying mechanisms were unclear, an animal model was developed to study the impact of maternal allergy on the development of an allergic immune response in early life. An allergic Th2 response was induced in pregnant mice by sensitization and aerosol allergen exposure. Both, IgG1 and IgG2a, but not IgE, Abs cross the placental barrier. Free allergen also crosses the placental area and was detected in serum and amniotic fluids of neonatal F1 mice. These F1 mice demonstrated a suppressed Th1 response, as reflected by lowered frequencies and reduced levels of IFN-γ production. Development of an IgE response against the same allergen was completely prevented early in life. This effect was mediated by diaplacental transfer of allergen-specific IgG1 Abs. In contrast, allergic sensitization against a different allergen early in life was accelerated in these mice. This effect was mediated by maternal CD4 and OVA-specific Th2 cells induced by allergic sensitization during pregnancy. These data indicate a critical role for maternal T and B cell response in shaping pre- and postnatal maturation of specific immunity to allergens.

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“…Breast‐feeding appears to modulate secretory (S)‐IgA production in infants, even if the mode of this effect is controversial (11–13). We have earlier reported that the levels of IL‐10 and TGF‐β, that both regulate IgA production, correlate with the levels of SIgA in breast milk (4).…”

mentioning

confidence: 99%

Cytokine, chemokine and secretory IgA levels in human milk in relation to atopic disease and IgA production in infants

Böttcher

Jenmalm

Björkstén

2003

Pediatric Allergy Immunology

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The relationship between breast-feeding, IgA production and development of atopic disease in children is a matter of controversy. Some of this controversy might be due to individual differences in the composition of breast milk. The aim of this study was to relate the levels of cytokines, chemokines and secretory (S)-IgA antibodies in breast milk to the development of atopic manifestation and salivary IgA production in infants. Cytokine, chemokine and SIgA levels, as measured with enzyme-linked immunosorbent assay (ELISA), in colostrum and mature milk were analyzed in relation to the development of positive skin-prick tests (SPT), allergic symptoms and salivary IgA antibody production during the first 2 years of life in 53 infants. There was no association between levels of IL-4, -5, -6, -8, -10, -13, -16, IFN-gamma, TGF-beta1, -beta2, RANTES, eotaxin or SIgA levels in the breast milk with either SPT-positivity, development of allergic symptoms or salivary IgA levels during the first 2 years of life in the infants. Thus, differences in the composition of cytokines, chemokines and SIgA in breast milk did not, to any major degree, affect the development of a positive SPT, atopic symptoms, nor salivary IgA antibody production during the first 2 years of life.

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Breast Feeding Modifies Production of SlgA Cow's Milk‐Antibodies in Infants

Cited by 16 publications

References 10 publications

Myths and facts about breastfeeding: Does it prevent later atopic disease?

Myths and facts about breastfeeding: Does it prevent later atopic disease?

Critical Role of Preconceptional Immunization for Protective and Nonpathological Specific Immunity in Murine Neonates

Cytokine, chemokine and secretory IgA levels in human milk in relation to atopic disease and IgA production in infants

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