Breast‐feeding prevents <i>Helicobacter pylori</i> infection in early childhood

Okuda, Masumi; Miyashiro, Eikici; Koike, Masato; Okuda, S.; Minami, Kouichi; Yoshikawa, Norishige

doi:10.1046/j.1442-200x.2001.01481.x

Cited by 30 publications

(38 citation statements)

References 9 publications

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“…The positive rate (32.8%) in the present study was higher than the average prevalence of 6 to 7% in this region of Japan, since we reinvited 29 positive children from a previous study (19).…”

Section: Resultscontrasting

confidence: 60%

“…The present study included 131 Japanese children (mean age, 5.5 years; range, 0 to 21 years; male, n ϭ 69; female, n ϭ 62) living in Wakayama Prefecture, a western part of Japan near Osaka. In a previous epidemiological study at Wakayama Rosai Hospital, 484 children were tested by HpSA, and 31 positive children were found (19). They were not treated because of the absence of upper-abdominal symptoms.…”

Section: Methodsmentioning

confidence: 99%

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A Strain-Specific Antigen in JapaneseHelicobacter pyloriRecognized in Sera of Japanese Children

Okuda

Sugiyama

Fukunaga

et al. 2005

Clin Vaccine Immunol

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An enzyme immuno assay (EIA) test based on Japanese strain-derived high-molecular-weight cell-associated proteins (JHM-CAP) was evaluated by comparing with a previously developed EIA test based on a U.S. strain-derived high-molecular-weight cell-associated proteins (HM-CAP). Serum samples of 131 Japanese asymptomatic children (mean age, 5.5 years; range, 0 to 21 years) were tested that include 43 positive and 88 negative children as judged by Helicobacter pylori stool antigen test (HpSA test). Both tests showed comparable and reliable specificities, but the sensitivity of JHM-CAP EIA, at 93.0%, was much higher than that of HM-CAP EIA, at 67.4%. More false-negative results of HM-CAP were obtained in children under 10 years of age. Immunoblot analysis revealed that the JHM-CAP but not the HM-CAP preparation had a 100-kDa antigen recognized by JHM-CAP positive sera. It was concluded that JHM-CAP EIA is highly accurate for the serodiagnosis of H. pylori infection in Japanese young children and that the high sensitivity of JHM-CAP EIA in contrast to HM-CAP EIA is due to the presence of a 100-kDa antigen in Japanese strains that may be recognized by the host immune system at an early stage of infection.

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Section: Resultscontrasting

confidence: 60%

Section: Methodsmentioning

confidence: 99%

A Strain-Specific Antigen in JapaneseHelicobacter pyloriRecognized in Sera of Japanese Children

Okuda

Sugiyama

Fukunaga

et al. 2005

Clin Vaccine Immunol

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“…In a study by Okuda et al, in Japan, it was shown that longer duration of breastfeeding can decrease the incidence of H. pylori infection in early childhood (12). Also, in a study in Shiraz, Iran, it was concluded that the incidence of H. pylori infection in exclusively breastfed infants was significantly lower than that of infants with other feeding regimens (16).…”

Section: Discussionmentioning

confidence: 99%

“…Some references suggest that breastfeeding for a longer period can decrease the risk of H. pylori infection (12). On the other hand, maternal H. pylori infection is an important risk factor to acquire H. pylori infection in infants and in a study in Brazil there was no difference between H. pylori infection in breastfed and never breast-fed infants (13), while in a study in Japan transmission of H. pylori infection from mother to the child was shown as the most probable cause of intrafamilial spread of the microorganism (14).…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Prevalence of Helicobacter pylori Infection Between the Exclusively Breastfed and Formula- or Mixed-Fed Infants in the First Six Months of Life

et al. 2017

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Background: Helicobacter pylori is a common gastrointestinal pathogen in human. The mechanism of its acquisition and transmission is unclear, although the most likely mode of transmission is fecal-oral or oral-oral. Most of infections occur in childhood. The current cohort assessed the prevalence of infection in infants with different feeding strategies (exclusive breastfeeding, formula, or mixed feeding). Methods: The current study was carried out in Vali-Asr hospital of Imam Khomeini hospital complex, Tehran, Iran, from 2012 to 2015.The study population included infants born in this hospital and registered in breastfeeding research center during the first 6 months of life. They were compared in 2 groups; exclusively breastfed, and formula or mixed fed. Mothers' H. pylori infection was checked serologically using the enzyme-linked immunosorbent assay (ELISA) technique and those of infants by monoclonal antibody test using ELISA technique on stool samples at 1st and 6th month of life. Results: A total of 102 infants in 2 groups (54 exclusively breastfed and 48 formula or mixed fed) completed the study. Mothers' serological assessments were positive in 68% of exclusively breast-fed subjects and 60% of formula or mixed fed subjects. All 1-monthold infants were negative for the infection and in the 6-month-old infants 10 cases (18.5%) were positive, 1 case was at borderline in the exclusively breastfed, and 13 cases (27%) were positive in formula-or mixed-fed subjects. This difference was not statistically significant (P = 0.302). The Mantel-Hanzel test was used to find a relationship in H. pylori positivity in mothers and infants during the first 6-month of life in each of the 2 groups. It was found that out of 37 serologically positive mothers in the breastfed group, 8 infants (22%) were H. pylori positive and in the formula and mixed-fed group, of 29 serologically positive mothers 10 infants (34%) were also H. pylori positive, but the difference between the groups was not statistically significant (P = 0.727). It meant that the prevalence of infantile H. pylori infection was similar in the 2 groups. Conclusions: The current study findings showed that exclusive breastfeeding had no role in protection or facilitation of H. pylori infection.

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“…16,18,19 This might be due to passive immunity by anti-H. pylori antibodies from breast milk, but further investigation is needed to confirm this finding although still controversial.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of and Factors Associated With Helicobacter Pylori Infection in Children in the North of Vietnam

Nguyen¹,

Nguyen²,

Phung³

et al. 2006

Am J Trop Med Hyg

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Abstract. The study aimed at evaluating the seroprevalence of and sociodemographic, health, lifestyle, and environmental hygiene conditions associated with Helicobacter pylori infection in Vietnamese children. Data from 824 children, aged from 6 months to 15 years and gastrointestinal symptom free when consulted, admitted to a university hospital, were collected using a structured questionnaire and ELISA test for H. pylori infection. The data were examined using univariate and multivariate analyses. H. pylori seroprevalence was 34.0%. Age groups from 3 to 6 years and older than 6, and number of offspring were positively and independently associated with H. pylori seropositivity [adjusted OR (95% CI): 2.9 (1.5-5.5); 1.9 (1.1-3.1) and 1.8 (1.1-2.6), respectively]. Breastfeeding more than 6 months was negatively and independently associated with H. pylori seropositivity [adjusted OR (95% CI): 0.5 (0.3-0.9)]. Mother's age, history of allergy, gastro-duodenal disease history in the past, initiating collective life before 6 years, sharing bed with parents and time of bed sharing with parents > 24 months were positively but not independently associated with H. pylori seropositivity. None of the other environmental or lifestyle conditions examined was associated with H. pylori infection. Our results support person-to-person transmission and the role of sociodemographic factors in H. pylori infection.

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Breast‐feeding prevents Helicobacter pylori infection in early childhood

Cited by 30 publications

References 9 publications

A Strain-Specific Antigen in JapaneseHelicobacter pyloriRecognized in Sera of Japanese Children

A Strain-Specific Antigen in JapaneseHelicobacter pyloriRecognized in Sera of Japanese Children

Comparison of the Prevalence of Helicobacter pylori Infection Between the Exclusively Breastfed and Formula- or Mixed-Fed Infants in the First Six Months of Life

Prevalence of and Factors Associated With Helicobacter Pylori Infection in Children in the North of Vietnam

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