Breast Imaging Reporting and Data Systems category 3 (probably benign) breast lesions detected on diagnostic breast ultrasound: The prevalence, outcome and malignancy detection rate in Zaria, Nigeria

Olarinoye-Akorede, Sefiya Adebanke; Yunusa, Garba Haruna; Aliyu, Halima; Hamidu, Ahmed Umdagas

doi:10.4102/sajr.v22i2.1315

Cited by 5 publications

(7 citation statements)

References 16 publications

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“…Our data showed that the overwhelming majority of histopathological results of the 2245 US-VAEB cases were benign breast disorders (88.5%), and only a small proportion (3.4%) was malignancies. The results are consistent with the literature [ 11 , 18 – 20 ]. It shows that criteria should be more strict to avoid unnecessary VAEB procedures for the patient’s clinical and economic benefit unless there is a specific request from the patient.…”

Section: Discussionsupporting

confidence: 93%

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Breast lesions excised via vacuum-assisted system: could we get any clues for B3 lesions before excision biopsy?

Zheng

Xing

et al. 2021

BMC Cancer

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Background The purpose of this study was to determine the validity of the ultrasound features as well as patient characteristics assigned to B3 (uncertain malignant potential) breast lesions before vacuum-assisted excision biopsy (VAEB). Methods This study population consisted of 2245 women with breast-nodular abnormalities, which were conducted ultrasound-guided VAEB (US-VAEB). Patient’s clinical and anamnestic data and lesion-related ultrasonic feature variables of B3 captured before US-VAEB were compared with those of benign or malignant cases, using histopathological results as a benchmark. Results The proportions of benign, B3 and malignant breast lesions diagnosed post-US-VAEB were 88.5, 8.2 and 3.4% respectively. B3 high frequent occurred in BI-RADS-US grade 3 (7.7%), grade 4a (11.0%) and grade 4b (9.1%). The overall malignancy underestimation rate of B3 was 4.4% (8/183). Malignant lesions were found mostly in the range of BI-RADS grade 4b (27.3%), grade 4c (33.3%) and grade 5 (100%). Multivariate binary logistic regression analyses (B3 vs benign) showed that non-menopausal patients (95% CI 1.628–8.616, P = 0.002), single (95% CI 1.370–2.650, P = 0.000) or vascularity (95% CI 1.745–4.150, P = 0.000) nodules in ultrasonic features were significant risk factors for B3 occurrences. In addition, patients elder than 50 years (95% CI 3.178–19.816, P = 0.000), unclear margin (95% CI 3.571–14.119, P = 0.000) or suspicious calcification (95% CI 4.010–30.733, P = 0.000) lesions were significantly associated with higher risks of malignant potentials for B3 cases (malignant vs B3). Conclusion The results of this study indicate that ultrasound findings and patients’ characteristics might provide valuable information for distinguishing B3 lesions from benign breast abnormalities before VAEB, and help to reduce malignancy underestimation of B3.

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Section: Discussionsupporting

confidence: 93%

“…Therefore, the diagnosis of B3 is much more challenging in clinical practice. It is reported that the approximate proportions of each biopsy results are normal/benign 70–98.89%, B3 < 10%, malignant < 2%, respectively [ 18 – 20 ]. The data indicate that most breast changes need not excision biopsy.…”

Section: Introductionmentioning

confidence: 99%

Breast lesions excised via vacuum-assisted system: could we get any clues for B3 lesions before excision biopsy?

Zheng

Xing

et al. 2021

BMC Cancer

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show abstract

“…Our data showed that the overwhelming majority of histopathological results of 2245 VAEB cases were benign breast disorders (88.5%), and only a small proportion (3.4%) was malignancies. The results are consistent with the literature [11,[18][19][20]. It shows that criteria should be more strict to avoid unnecessary VAEB procedures for the patient's clinical and economic bene t unless there is a speci c request from the patient.…”

Section: Discussionsupporting

confidence: 90%

“…Therefore, the diagnosis of B3 is much more challenging in clinical practice. It is reported that the approximate proportions of each biopsy results are normal/benign 70%-98.89%, B3 < 10%, malignant < 2%, respectively [18][19][20]. The data indicate that most breast changes need not excision biopsy.…”

Section: Introductionmentioning

confidence: 99%

Breast lesions excised via Vacuum-Assisted System: Could We Get Any Clues for B3 Lesions Before Excision Biopsy?

Zheng

Xing

et al. 2021

Preprint

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Background: The purpose of this study was to determine the validity of the ultrasound features as well as patient characteristics assigned to B3 (uncertain malignant potential) breast lesions before vacuum-assisted excision biopsy (VAEB).Methods: This study population consisted of 2245 women with breast-nodular abnormalities, which were conducted ultrasound-guided VAEB (US-VAEB). Patient’s clinical and anamnestic data and lesion-related ultrasonic feature variables of B3 were compared with those of benign or malignant cases, using histopathological results as a benchmark. Results: The proportions of benign, B3 and malignant breast lesions were 88.5%, 8.2% and 3.4% respectively. B3 high frequent occurred in BI-RADS-US grade 3 (7.7%), grade 4 (9.3%), grade 4a (11.3%) and grade 4b (9.1%). The overall malignancy underestimation rate of B3 cases was 4.4% (8/183). The more common malignancy underestimation of B3 subtypes were PL/ADH 50% (1/2), ADH 23.1% (3/13), and CSL/RS 16.7% (1/6). And the highly frequent recurrence rates of B3 subtypes were ADH 10% (1/10), PL 4.9% (4/82), and PT 8.6% (6/70). Multivariate binary logistic regression analyses (B3 vs benign) showed that non-menopausal patients (95% CI 1.628-8.616, P = 0.002), single (95% CI 1.370-2.650, P = 0.000) or abundant blood supply (95% CI 1.745-4.150, P = 0.000) nodules via ultrasound examination were significant risk factors for B3 occurrences. Moreover, patients elder than 50 years (95% CI 3.178-19.816, P = 0.000), unclear margin (95% CI 3.571-14.119, P = 0.000) or microcalcification (95% CI 4.010-30.733, P = 0.000) nodules were significantly associated with higher risks of malignant potentials (B3 vs malignant).Conclusion: The results of this study indicate that ultrasound findings and patients’ characteristics could provide valuable information for distinguishing B3 cases from benign or malignant cases before VAEB.

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“…15 22 The remaining 1063 breast solid masses were probably benign, having a low (<2%) risk of malignancy; for these masses, definitive management depends on whether they are upgraded to malignant or downgraded to benign lesions. 23 For such cases, close short-term imaging follow-up would be ideal, especially in the initial 6 months after diagnosis. 24 Follow-up based on imaging rather than biopsy for lesions sonographically described as probably benign will reduce medical costs and unnecessary invasive procedures.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of breast fibroadenoma in healthy physical examination population in Guangdong province of China: a cross-sectional study

et al. 2022

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ObjectiveTo provide an accurate assessment of the prevalence of breast fibroadenoma in a large population and to confirm the diagnostic accuracy of ultrasound for fibroadenoma.DesignThis was a cross-sectional survey.SettingThis research was conducted at Nanfang Hospital, Guangzhou, Guangdong, China.ParticipantsA total of 11 898 women aged 18–40 years who underwent breast screening between 1 January 2019 and 31 December 2019 were included in the fibroadenoma prevalence study. From 1 June 2019 to 31 December 2019, 342 breast lesions with pathology reports and preoperative ultrasound images were collected for diagnostic fibroadenoma testing (vs histological diagnostic testing).Primary outcome measuresPearson’s χ2 test was performed to compare the prevalence of different lesions between age groups, and descriptive statistics were used to report the clinical characteristics of fibroadenoma. For ultrasound diagnosis, fibroadenoma was defined as a well-circumscribed lesion with round or oval shape, consisting of a homogeneously hypoechoic or isoechoic solid mass, located parallel to the chest wall with a smooth margin and no posterior shadowing. Diagnostic test results for breast fibroadenoma were stratified by diagnostic type (histological vs ultrasound).ResultsOf the women aged 18–40 years, 27.6% (3285/11 898) had an ultrasound diagnosis offibroadenoma. Of these, the prevalence of fibroadenoma was stable across age groups (p=0.14) and did not differ between the left and right sides of the breast. Almost two-thirds of women presented with a single fibroadenoma, and most fibroadenomas did not exceed 1 cm in size. The sensitivity and specificity for fibroadenoma were 97.0% (95% CI for sensitivity: 93.7% to 98.8%) and 91.4% (95% CI for specificity: 85.4% to 95.5%) for ultrasonography, respectively.ConclusionsThe prevalence of fibroadenoma in South China is as high as 27.6%, and ultrasound could be used as a tool to diagnose fibroadenoma.

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Breast Imaging Reporting and Data Systems category 3 (probably benign) breast lesions detected on diagnostic breast ultrasound: The prevalence, outcome and malignancy detection rate in Zaria, Nigeria

Cited by 5 publications

References 16 publications

Breast lesions excised via vacuum-assisted system: could we get any clues for B3 lesions before excision biopsy?

Breast lesions excised via vacuum-assisted system: could we get any clues for B3 lesions before excision biopsy?

Breast lesions excised via Vacuum-Assisted System: Could We Get Any Clues for B3 Lesions Before Excision Biopsy?

Prevalence of breast fibroadenoma in healthy physical examination population in Guangdong province of China: a cross-sectional study

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