Breast Lesions Detected via Molecular Breast Imaging

Ching, Jason; Brem, Rachel F.

doi:10.1016/j.acra.2018.03.004

Cited by 4 publications

(5 citation statements)

References 37 publications

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“…Amorphous microcalcifications are the most common imaging presentation of ADH [ 28 , 29 , 30 ]. Our findings confirm these data, with microcalcifications being the most common form of presentation in patients diagnosed with ADH: most biopsies were therefore performed under stereotactic guidance.…”

Section: Discussionmentioning

confidence: 99%

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Atypical Ductal Hyperplasia after Vacuum-Assisted Breast Biopsy: Can We Reduce the Upgrade to Breast Cancer to an Acceptable Rate?

et al. 2021

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(1) Background: to evaluate which factors can reduce the upgrade rate of atypical ductal hyperplasia (ADH) to in situ or invasive carcinoma in patients who underwent vacuum-assisted breast biopsy (VABB) and subsequent surgical excision. (2) Methods: 2955 VABBs were reviewed; 141 patients with a diagnosis of ADH were selected for subsequent surgical excision. The association between patients’ characteristics and the upgrade rate to breast cancer was evaluated in both univariate and multivariate analyses. (3) Results: the upgrade rates to ductal carcinoma in situ (DCIS) and invasive carcinoma (IC) were, respectively, 29.1% and 7.8%. The pooled upgrade rate to DCIS or IC was statistically lower at univariate analysis, considering the following parameters: complete removal of the lesion (p-value < 0.001); BIRADS ≤ 4a (p-value < 0.001); size of the lesion ≤15 mm (p-value: 0.002); age of the patients <50 years (p-value: 0.035). (4) Conclusions: the overall upgrade rate of ADH to DCIS or IC is high and, as already known, surgery should be recommended. However, ADH cases should always be discussed in multidisciplinary meetings: some parameters appear to be related to a lower upgrade rate. Patients presenting these parameters could be strictly followed up to avoid overtreatment.

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Section: Discussionmentioning

confidence: 99%

“…ADH diagnosed by breast biopsy is associated with a high incidence of DCIS and IC at the subsequent surgical excision [ 7 , 10 , 30 , 31 , 32 ], as demonstrated by recent metanalyses [ 33 , 34 ] reporting an upgrade rate of 9% for invasive carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Atypical Ductal Hyperplasia after Vacuum-Assisted Breast Biopsy: Can We Reduce the Upgrade to Breast Cancer to an Acceptable Rate?

et al. 2021

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“…Furthermore, it was concluded that BPU heterogeneity did not significantly affect the prediction of positivity. However, dense breasts had more findings than non-dense breasts 22 . The association of BPU with predicting the development of breast cancer in post-and pre-menopausal women in five years was evaluated in a 2020 cohort.…”

Section: Editorial Comment Regarding Article 20 [3] Namentioning

confidence: 77%

“…MBI in clinical practice, as a complement to mammography in the detection of breast cancer, has been reported by several studies 6,7,22 . The pros of this imaging method are: easy interpretation, high rate of inter-observer agreement, high diagnostic accuracy and not being operator-dependent, like ultrasonography.…”

Section: Discussionmentioning

confidence: 93%

“…Some studies used subjective categories to classify BPU into four groups: photopenic aspect (lower uptake than that observed in subcutaneous fat), minimal to mild (equal to or a little higher than fat), moderate (greater than mild, but less than twice the uptake in fat) and accentuated (at least twice greater than seen in fat) 2,3,19,22 . Due to possible variations between different observers, a quantitative method was proposed for a more accurate reproducibility of this classification 2 .…”

Section: Editorial Comment Regarding Article 20 [3] Namentioning

confidence: 99%

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Molecular breast imaging and background uptake of fibroglandular tissue as tools to predict neoplasms in dense breasts

Viviani

Veras²,

Viviani

et al. 2021

Mastology

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The sensitivity of mammography as a screening method is low in dense breasts, which are associated with a high risk of developing tumors. Thus, molecular breast imaging (MBI) with background uptake (BPU) of fibroglandular tissue can be used as a complementary method. The aim of this review was to synthesize the existing evidence on these important diagnostic imaging tools. Three electronic databases were searched to identify original articles, including publications dating from September 2010 and September 2020, in English, conducted in any location, and addressing at least one aspect related to dense breasts and Breast-specific gamma-imaging (BSGI). In total, 22 studies were reviewed. Several advantages of MBI and BPU as complementary methods of screening for dense breasts were found. Among them, we can mention the increase in breast cancer detection rate, easy implementation in clinical practice, high patient satisfaction, low cost and good reproducibility. In view of the good results found in our review, we can conclude that the implementation of MBI, especially with BPU, can be a promising complementary tool for screening of dense breasts.

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Background parenchymal enhancement and uptake as breast cancer imaging biomarkers: A state-of-the-art review

Bauer¹,

Levy²,

Domachevsky³

et al. 2022

Clinical Imaging

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Breast Lesions Detected via Molecular Breast Imaging

Cited by 4 publications

References 37 publications

Atypical Ductal Hyperplasia after Vacuum-Assisted Breast Biopsy: Can We Reduce the Upgrade to Breast Cancer to an Acceptable Rate?

Atypical Ductal Hyperplasia after Vacuum-Assisted Breast Biopsy: Can We Reduce the Upgrade to Breast Cancer to an Acceptable Rate?

Molecular breast imaging and background uptake of fibroglandular tissue as tools to predict neoplasms in dense breasts

Background parenchymal enhancement and uptake as breast cancer imaging biomarkers: A state-of-the-art review

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